计算机在药物研究中的综合实践课程设计与实施

作为本科生理论综合应用能力和创新能力的拓展课程,《计算机在药物研究中的综合实践》设置了复合型目标,由理论讲授-验证实验-开放式探索型实验阶段过渡,内容在理论方面注重经典、探索型实验选择方面注重前沿,采用全班集中学习和分组实验教师指导两种方式,取得较理想的教学效果。     

综合护理对妇产科患者术后疼痛的效果观察

目的探讨综合护理对妇产科患者术后疼痛的改善效果。方法选取我院从2013年1月~2014年1月所收治的260例妇产科患者作为临床研究对象,将所有患者随机分为护理组和对照组两组,对照组患者采用常规护理措施,护理组患者采用综合护理措施。评价两组患者的术后疼痛情况,以评价护理效果。结果护理组患者0级率为36.2%,对照组为15.4%;护理组患者3级率为1.5%,对照组为18.5%。两组比较,差异有统计学意义(P0.05)。结论综合护理干预能对妇产科手术患者的术后疼痛有较好的缓解,促进患者的快速康复。     

Education programmes for young children with Autism Spectrum Disorder: An Evaluation Framework

Autism researchers have identified a common set of practices that form the basis of quality programming in ASD yet little is known regarding the implementation of these practices in community settings. The purpose of this paper was to outline an Evaluation Framework for use in evaluating ASD programmes of education that will provide valuable information as to the sensitivity of programmes to best practice, establish how programmes are operating and the programme effect on students and their families. The move towards more rigorous evaluation will provide quality information as to the degree of adoption of research led practices in the community setting which heretofore has been largely unavailable.     

责任护理模式在改善腹腔镜子宫切除术患者围术期综合状态中的效果观察

目的探讨研究责任护理模式在改善腹腔镜子宫切除术患者围术期综合状态中的效果。方法将2011年9月-2012年12月采用腹腔镜子宫切除术进行治疗的60例患者依据随机数字表法分为对照组30例和观察组30例，对照组以常规护理进行干预，观察组则以责任护理模式进行干预，将两组患者分别于干预前及干预后5、10d时采用AIS量表、SCL-90量表及WHOQOL量表对其休息状态、心理状态及综合生活质量进行评估。结果观察组干预后5、10d时的AIS量表、SCL-90量表及WHOQOL量表评分均明显地优于对照组干预后5、10d时的评分，且观察组干预前至干预卮5、10d评分呈现持续改善，差异均有统计学意义（均P〈0．05）。结论责任护理模式在改善腹腔镜子宫切除术患者围术期综合状态中的效果较好。     

护理干预预防川崎病患儿发生静脉血栓的临床价值

目的探究综合护理干预预防川崎病患儿发生静脉血栓的临床价值。方法回顾性分析我院于2012年3月~2016年3月期间的川崎病患儿的临床资料,共计302例。以2014年5月开展综合护理干预为界点,2014年5月前,采用常规护理干预的150例崎病患儿作为参照组,2014年5月后实施综合护理干预的152例患儿为研究组。观察并比较两组患儿护理后的热程、退热时间、手足肿胀时间等治疗相关指标、治疗依从性、静脉血栓发生率、死亡率以及对护理的满意度。结果经过护理后,研究组患儿的热程、退热时间、手足肿胀时间、淋巴结肿大消退时间、黏膜充血时间均少于参照组,依从性及满意度高于参照组,静脉血栓发生率、死亡率均低于参照组,组间比较具有差异性,存在统计学意义(P0.05)。结论两组患者经过护理后都有一定成效,但研究组疗效更显著,川崎病患儿采用综合护理干预,能改善临床症状,有效预防静脉血栓形成,降低死亡率,具有较高的临床价值。     

地方综合性大学临床医学教育体制改革探索实践

医学教育体制的探索和创新根本出发点是为了整合临床资源,提高教学质量,特别在地方综合性高校任务尤为艰巨。研究探索实施最大限度发挥以地方高校的唯一性,高效整合医疗资源,并实现优势医疗资源向教学资源的转化,有效弥补地方教学资源相对缺乏为特色的临床教育体制改革。     

Renal Effects of Crizotinib in Patients With ALK-Positive Advanced NSCLC

IntroductionWe retrospectively analyzed the effects of crizotinib on serum creatinine and creatinine-based estimated glomerular filtration rate (eGFR) in patients with anaplastic lymphoma kinase–positive advanced NSCLC across four trials (NCT00585195, NCT00932451, NCT00932893, and NCT01154140).MethodsChanges from baseline data in serum creatinine and eGFR, calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine-based equation, were assessed over time. eGFR was graded using standard chronic kidney disease criteria.ResultsMedian serum creatinine increased from 0.79 mg/dL at baseline to 0.93 mg/dL after 2 weeks of treatment (median percentage increase from baseline, 21.2%), was stable from week 12 (0.96 mg/dL) to week 104 (1.00 mg/dL), and decreased to 0.90 mg/dL at 28 days after last dose (median percentage increase from baseline, 13.1%). Median eGFR decreased over time (96.42, 80.23, 78.06 and 75.45 mL/min/1.73 m² at baseline, week 2, week 12, and week 104, respectively) and increased to 83.02 mL/min/1.73 m² at 28 days after the last dose. Median percentage decrease from baseline was 14.9%, 17.0%, and 10.4% at week 2, week 12, and 28 days after last dose of crizotinib, respectively. Overall, 12.6% of patients had a shift from eGFR grade less than or equal to 3a (≥45 mL/min/1.73 m²) at baseline to greater than or equal to 3b (<45 mL/min/1.73 m²) post-baseline.ConclusionsCrizotinib resulted in a decline in creatinine-based estimates of renal function mostly over the first 2 weeks of treatment. However, there was minimal evidence of cumulative effects with prolonged treatment and these changes were largely reversible following treatment discontinuation, consistent with previous reports suggesting this may be predominantly an effect on creatinine secretion as opposed to true nephrotoxicity.     

Comprehensive Tool to Assess Oral Feeding Support for Functional Recovery in Post-acute Rehabilitation

Objective

To determine the influence of the Kuchi-kara Taberu (KT) index on rehabilitation outcomes during hospitalized convalescent rehabilitation.