灯盏细辛对青光眼神经保护作用的临床研究

目的　评价灯盏细辛对眼压已控制的青光眼神经保护作用。方法　采用前瞻性、随机、双盲、安慰剂对照的研究方法 ,将眼压已控制的中晚期青光眼患者共 45例 ( 4 5眼 ) ,分层随机分为年龄匹配的灯盏细辛治疗组 ( 2 3例 )和安慰剂对照组 ( 2 2例 )。治疗组口服灯盏细辛 (EBHM) 2片 ,3次 /d ,对照组口服安慰剂 ,连续 6个月 ,每月复诊 1次。治疗前及每月复诊均检查矫正视力、眼压、视乳头杯盘比 (C/D)、自动静态阈值视野、血压和脉搏。结果　EBHM组与对照组在 6个月中平均眼压分别为 14 17mmHg± 2 5 0mmHg( 8～ 2 1mmHg)和 14 5 2mmHg± 1 94mmHg( 8～ 19mmHg) (P =0 5 98)。治疗 6个月后EBHM组平均敏感度 (MS)增加 1 42dB ,对照组MS下降 0 95dB(P =0 0 0 0 )。EBHM组和对照组视野进步率分别为 5 6 5 2 %和 4 5 5 % (P =0 0 0 1)。结论　灯盏细辛为一安全、无毒副作用的中草药 ,具有提高青光眼患者MS和部分改善原有视野缺损的作用 ,可作为视神经保护剂应用于治疗眼压已控制的青光眼。     

Histopathological and ultrastructural changes in liver tissue from burned patients

Histopathological studies were made on samples of liver and spleen tissue taken post mortem from 59 patients with severe burns. Samples from 8 patients were also studied using the transmission electron microscope. The main pathological findings were degeneration and necrosis of hepatic cells and proliferation of Kupffer cells showing active phagocytosis. Their causes in relation to the time of death after burning and severity of injury have been discussed. The proliferation of Kupffer cells may be a compensatory reaction to the severe splenic injury seen in the patients.     

Carcinosarcoma of the salivary gland

A 59-year-old woman had carcinosarcoma of the salivary gland. Salivary gland tumors of this type are aggressive and rare. Most patients die of the tumor, but surgical cure has been reported in one case.     

揆度求奇恒 黄溪无止境——黄山名士陈无咎医学思想撷析

简述民国时期黄山名士陈无咎的传奇经历,分析其医学思想。治学宗从《内经》,实践崇尚揆度;弘扬丹溪学说,创办中医院校;主张取长补短,融汇中西医学,旨在发展中医。     

Is lymph node dissection necessary for resectable intrahepatic cholangiocarcinoma? A systematic review and meta-analysis

BackgroundThe objective of this meta-analysis was to evaluate the effectiveness and safety of lymph node dissection (LND) in patients with intrahepatic cholangiocarcinoma (ICC).MethodsA literature search with a date range of January 2000 to January 2018 was performed to identify studies comparing lymph node dissection (LND+) with non-lymph node dissection (LND-) for patients with ICC. The LND + group was further divided into positive (LND + N+) and negative (LND + N-) lymph node status groups based on pathological analysis.Results13 studies including 1377 patients were eligible. There were no significant differences in overall survival (OS) (HR 1.13, 95% CI 0.94–1.36; P = 0.20), disease-free survival (DFS) (HR 1.23, 95% CI 0.94–1.60; P = 0.13), or recurrence (OR 1.39, 95% CI 0.90–2.15; P = 0.14) between LND + group and LND-group. Postoperative morbidity was significantly higher in the LND + group (OR 2.67, 95% CI 1.74–4.10; P < 0.001). A subset analysis showed that OS was similar between LND + N- and LND-groups (HR 1.13, 95% CI 0.82–1.56; P = 0.450). However when comparing, OS of the LND-group to the LND+N+ group there was a significant increase in OS for the LND-group (HR 3.26, 95% CI 1.85–5.76; P < 0.001).ConclusionsLND does not seem to positively affect overall survival and is associated with increased post-operative morbidity.     

玉林市2002—2010年肺结核流行状况分析

摘要：目的了解广西玉林市活动性肺结核流行现状。方法根据2002年以来玉林市结核病防治机构初诊病人登记、结核病人登记、季报表、月报表、结核病网络专报系统对玉林市2002～2010年活动性肺结核流行状况进行分析。结果玉林市2002—2010年共登记活动性肺结核病人30950例,年均活动性肺结核登记率为55．58／10万;其中共登记新涂阳病人12159例,年均新涂阳登记率为21．83／10万;复治涂阳病人共1568例,年均复治涂阳病人登记率为2．82／10万;活动性发病率由2006年的75．66％下降到2010年的51．87％;复治涂阳病人年登记率由2006年的33．27％下降到2010年的1．62％。全年均有发病,3月发病最多,1月份发病最少。男性比女性多发,发病主要是农民,各县发病平均。结论玉林市结核病防治工作成效显著,今后应加强农村的结核病防控工作。     

陈自明治疗月水不通的用药特点探析

文章通过研究《妇人大全良方》中有关妇人月水不通的方剂,总结陈氏治疗月水不通的特点。病因方面,陈氏认为妇人常由"劳伤血气致令体虚""受风冷邪气客于胞内"内外两方面因素损伤冲任,使胞络内血绝不通而经闭,病因重视气血亏虚、风冷乘袭。治疗方面,陈氏重视"补通"以调经。通过统计分析陈氏治疗月水不通的34首方剂,发现其用药方面具有重视养血活血,药性偏温平,药味多苦辛甘,善用虫类药攻坚通络,服药方法灵活多样等特点,均体现了"补通"以调经的治疗原则。     

Performance evaluation of medical services in nine urban public hospitals based on patient reported experience: a cross-sectional survey

Background

The public hospital reform in China was launched in April 2009. Whether patients are satisfied with medical services or not is an important index to measure the effectiveness of the public hospital reform. We aimed to explore whether patients experience improved medical service under the public hospital reform.

Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins

Intercellular karyotypic compositions were studied in seven near-diploid cultured cell populations (including six cell lines) of human colorectal and fibrosarcoma origins. Within each population, 50–88% of cells had the same cell-line-specific karyotype. In five of these seven populations, coexisting minor cell types could readily be identified, implicating the frequent occurrence of mosaicism in transformed cell lines. Nearly 90% of these cell types showed a single chromosome loss or gain from the modal cell karyotype. Parameters that may assist in the evaluation of karyotypic diversity of a transformed cell line are discussed briefly.     

Modal karyotype of human leukemia cell line, K562 (ATCC CCL 243)

The chromosome composition of the human leukemic cell line, K562, deposited at the American Type Culture Collection (ATCC) (CCL 243), was studied and further compared with those reported by other laboratories. In CCL 243, the modal karyotype had 55 normal and 14 constitutive marker chromosomes and occurred in nearly 50% of the cultured cell population. Other variant karyotypes were observed either at a low frequency in coexisting minor cell types or only once in all other analyzed metaphases. Normal chromosome #9 and the chronic myeloid leukemia (CML) specific Ph/t(9;22) were absent. It appears that karyotypes of most K562 cultures distributed world-wide are similar to each other, with the stable modal chromosome number, and therefore, the modal karyotype presented here should be useful in karyotypic identification of a cell line.