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71.
目的:为了弄清蒿甲醚合成母液中的衍生杂质结构及开发新的药源。方法:用色谱法从合成蒿甲醚的母液中分离其衍生物成分,并用化学波谱法鉴定其结构,结果:分离得到5个化合物分别鉴定为α-蒿甲醚(Ⅰ),二氢青蒿素(Ⅱ),青蒿素(Ⅲ),八氢-8-甲氧基-4,7-二甲基-呋喃[3,2-i]苯并吡喃-10-乙酸酯(Ⅳ)和12-脱氧-11-烯青蒿素(Ⅴ)。结论:化合物Ⅴ为一新化合物,命名为12-脱氧-11-烯青蒿素,并首次从合成蒿甲醚的母液中得到。 相似文献
72.
缺氧和血清剥夺诱导的PC12细胞DNA损伤与修复 总被引:1,自引:0,他引:1
探讨 PC12细胞在缺氧 ( 3 7℃ ,5 % O2 ,95 % N2 )、血清剥夺条件下 DNA损伤与修复、凋亡、坏死或生存的变化规律。应用单细胞凝胶电泳技术、流式细胞学技术检测在不同时间点 ,缺氧、无血清培养等诱导下对 PC12细胞单链 DNA损伤与修复、凋亡的影响。结果发现在 PC12细胞 DNA损伤值均在 0 .5 h时达第一个峰值 ,随后下降。 3 h后DNA损伤数值再次逐渐增加并达到最高值。细胞凋亡峰值略滞后于 DNA损伤峰值 ,并于 DNA损伤程度基本相平行。提示 PC12细胞在缺氧和血清剥夺条件下存在 DNA损伤与修复的动态变化过程 ,DNA损伤后可能直接诱导细胞凋亡 ,DNA损伤程度在早期与细胞凋亡程度相一致 相似文献
73.
The relationships between cancer caused by HPV and some vitamins, as well as leucocytes and their ratios, have been investigated in the literature. Our aim is to evaluate these relationships at the level of genital wart in terms of the investigated parameters and lesion numbers. Data were obtained from 98 and 94 patients for groups one and two, including warts patients and healthy people respectively. The Neutrophil/Monocyte ratio and lesion numbers in the warts patients were reported and analysed in terms of vitamin B12 and D, ferritin and leucocytes. A correlation was established between lesion numbers, age and midcorpuscular volume (p <0.05). There was no correlation between lesion numbers and recurrence. According to the comparative analysis, there were differences in terms of ferritin, neutrophil, monocyte, haemoglobin, midcorpuscular volume and neutrophil/monocyte ratio between groups. The cut-off values for neutrophil, monocyte and N/M ratios were 56.45, 4.91 and 7.825 respectively. While our study showed that wart development may be affected by blood ferritin levels and in this situation, midcorpuscular volume, neutrophil, monocyte and N/M ratios may change, a relation was found between lesion numbers and age and mean midcorpsucular volume values only. However, further studies are needed to clarify this issue. 相似文献
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This paper investigates the role of biased health perceptions as a potential driving force of risky health behaviors. We define absolute and relative health perception biases, illustrate their measurement in surveys and provide evidence on their relevance. Next, we decompose the theoretical effect into its extensive and intensive margin: When the extensive margin dominates, people (wrongly) believe they are healthy enough to “afford” unhealthy behavior. Finally, using three population surveys, we provide robust empirical evidence that respondents who overestimate their health are less likely to exercise and sleep enough, but more likely to eat unhealthily and drink alcohol daily. 相似文献
77.
Safarova ER Shram SI Zolotarev YA Myasoedov NF 《Bulletin of experimental biology and medicine》2003,135(3):268-271
We studied the effects of Semax (antiinsulin peptide with neuroprotective effect) on the survival of cultured rat pheochromocytoma cell after oxidative stress induced by short-term incubation with hydrogen peroxide. Studies with fluorescent dyes propidium iodide and Hoechst 33258 showed that cell incubation with hydrogen peroxide led to the formation of damaged cells with characteristic signs of necrosis. Semax dose-dependently reduced the number of cells damaged by oxidative stress. The efficiency of Semax depended on the time of its addition to the culture medium. The results suggest that the neuroprotective effect of Semax in ischemic stroke can be due to its capacity to protect neurons from damage caused by oxidative stress. 相似文献
78.
D Kabelitz 《Immunobiology》1985,169(4):436-446
We have analyzed the regulatory effects of two classes of tumor promoters, phorbol diesters and indole alkaloids, on human natural killer (NK) cell activity in vitro. In accordance with previous reports, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibited natural killing against K 562 targets by unseparated mononuclear cells. Here, suppression of NK required the presence of adherent cells (macrophages). Contrary to the results obtained with K 562, tumor promoter-induced suppression of NK activity tested against U 937, another cell line of known NK susceptibility, was independent of the presence of adherent cells. Thus, NK cytotoxicity of effector cells rigorously depleted of adherent and Ia-positive cells was still inhibited when assayed against U 937, while it was generally enhanced when tested against K 562. Identical results were obtained with teleocidin and dihydroteleocidin B, two members of the recently discovered indole alkaloid class of tumor promoters. Therefore, we demonstrate that the regulatory effect of tumor promoters on human NK activity (suppression or stimulation) is determined not only by macrophages at the effector cell level but also by the type of target cell under study. 相似文献
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