射频消融治疗阵发性室上性心动过速262例分析

经导管射频消融治疗阵发性室上性心动过速（ＰＳＶＴ）２６２例,探讨ＲＦＣＡ治疗ＰＳＶＴ的安全性及疗效。方法：房室结双径路改良采用下位法;左侧旁道采用冠状窦电极粗标,大头电极在心室国标。右侧旁道采用左前斜４５度。大头电极在心房侧三尖瓣环处细标;房扑时标测心房激动顺序,用隐匿必拖法确定折返环部位,在心房内行线性消融方法治疗。结果：２６２例中慢－快型房室结折生心动过速（ＡＶＮＲＴ）７８例。,房室折返性心动     

Electrocardiological profile and proarrhythmic effects of quinidine,verapamil and their combination: a mapping study

Quinidine and verapamil are widely used as antiarrhythmic agents and their combination is often used in the treatment of supraventricular tachycardia. This study was undertaken to clarify, whether these drugs exert proarrhythmic effects on the ventricles in therapeutic concentrations and whether possible arrhythmogenic effects might be enhanced by combination. Isolated rabbit hearts perfused according to the Langendorff technique were treated with increasing concentrations of quinidine (0.05 to 3.5 M) or verapamil (5 to 50 M) or of their combination (70:1 or 10:1; quinidine:verapamil) corresponding to common low, medium and high free therapeutic concentrations. The epicardial activation process was measured using a computer assisted mapping system for unipolar multichannel recording (256 channels simultaneously).Both substances prolonged the atrioventricular conduction time PQ. This effect was even more pronounced if the 70:1 combination was administered. The activation pattern was altered by both drugs and their combination to the same extent as became obvious from analysis of local activation vectors and of localisation of breakthroughpoints of epicardial activation for heart beats under control conditions and under drug treatment. The epicardial potential durations were prolonged by quinidine and to the same degree by the combinations, but not by verapamil alone. The total activation time was prolonged under the influence of quinidine and if the 70:1 combination was given. Both substances exerted a negative inotropic effect which was enhanced in an additive manner if both drugs were combined. In parallel the coronary flow was diminished.From these results it is concluded that (1) in this therapeutic concentration range quinidine possess a greater proarrhythmic risk than verapamil, (2) that both drugs' PQ prolonging effect can be enhanced by combination, (3) that combination does not enhance the proarrhythmic effects but the negative inotropic effects.     

射频能量时间递增法治疗房室结折返性心动过速

目的：评估射频能量时间递增法治疗４０ 例房室结内折返性心动过速的疗效及安全性。　方法：标测到理想的慢径路靶点后,从小功率（１０～１５ Ｗ）、短时间（５～１０ ｓ）放电开始,如出现交界区早搏或交界区心律,逐渐增加放电功率（２０～２５ Ｗ）和持续时间（３０～６０ ｓ）,并密切观察房室传导阻滞的迹象和先兆。　结果：临床治愈率９７．５％ ,无一例产生严重并发症。　结论：射频能量时间递增法是一种安全、高效的治疗方法。     

房室隔缺损的手术治疗

目的　总结 31例房室隔缺损 (atrioventricularseptaldefect,AVSD)手术治疗经验。方法　 31例中部分型 (PAVSD) 11例 ,中间型 (MAVSD) 5例 ,完全型 (CAVSD) 15例。采用 5 0聚丙烯线往返连续缝合的方法闭合左房室瓣大瓣裂缺。部分病例同时进行左房室瓣或右房室瓣成形术。采用新鲜自体心包片或涤纶片修补原发孔房间隔缺损 ,将冠状窦口隔入右房侧。CAVSD 15例中 ,11例按McGoon“单片法”修补 ,4例用“双片法”修补。结果　PAVSD及MAVSD无手术死亡 ,1例CAVSD根治术后早期死于严重低心排 ,死亡率3 2 %。术后随访左房室瓣中度返流 1例 ,轻度返流 4例。全组病人术后无Ⅲ°房室传导阻滞 ,左室流出道狭窄及房、室缺残余漏。结论　PAVSD及MAVSD如无肺高压、严重左房室瓣返流及左室流出道狭窄 ,手术可在 1～ 2岁进行 ,否则应尽早手术。而CAVSD由于大量左向右分流和房室瓣返流 ,大多数患儿 6～ 12个月即出现肺血管阻塞性病变 ,应在肺血管病变发生前行根治术。     

房室结阻断加永久起搏与房室结改良治疗心房纤颤的疗效研究

目的评价房室结阻断加永久起搏(AVNAP)和房室结改良(AVNM)治疗心房纤颤(AF)的效果.方法32例药物难治性AF患者,分成AVNAP(18例)和AVNM(14例)两组.采用NYHA心功能分级、左室射血分数(LVEF)、6 m in步行试验(6-MWT)、“SF-36问卷”生活质量评分等方法进行评价.结果平均随诊14月,AVNAP组LVEF由治疗前的(47±9)%增至(57±6)%(P<0.01),心功能分级由2.2±0.7降至1.4±0.5(P<0.05),6-MWT明显增加,SF-36生活质量评分明显改善.住院次数明显减少、停服抗心律失常药.AVNM组LVEF、心功能、6-MWT、生活质量的改善不如AVNAP组.结论对药物难治性AF、AVNAP和AVNM均有效,但AVNAP明显优于AVNM和常规药物治疗.