全文获取类型
收费全文 | 189710篇 |
免费 | 18931篇 |
国内免费 | 9280篇 |
专业分类
耳鼻咽喉 | 2566篇 |
儿科学 | 4182篇 |
妇产科学 | 2068篇 |
基础医学 | 35874篇 |
口腔科学 | 6454篇 |
临床医学 | 15410篇 |
内科学 | 25213篇 |
皮肤病学 | 4677篇 |
神经病学 | 11939篇 |
特种医学 | 4178篇 |
外国民族医学 | 121篇 |
外科学 | 17998篇 |
综合类 | 29301篇 |
现状与发展 | 49篇 |
一般理论 | 2篇 |
预防医学 | 5253篇 |
眼科学 | 3918篇 |
药学 | 14133篇 |
36篇 | |
中国医学 | 5624篇 |
肿瘤学 | 28925篇 |
出版年
2024年 | 440篇 |
2023年 | 2773篇 |
2022年 | 4834篇 |
2021年 | 6744篇 |
2020年 | 6123篇 |
2019年 | 6267篇 |
2018年 | 6979篇 |
2017年 | 6462篇 |
2016年 | 6960篇 |
2015年 | 7966篇 |
2014年 | 11799篇 |
2013年 | 12914篇 |
2012年 | 10841篇 |
2011年 | 12325篇 |
2010年 | 10246篇 |
2009年 | 9708篇 |
2008年 | 10060篇 |
2007年 | 10178篇 |
2006年 | 9218篇 |
2005年 | 8605篇 |
2004年 | 7399篇 |
2003年 | 6270篇 |
2002年 | 5119篇 |
2001年 | 4341篇 |
2000年 | 3787篇 |
1999年 | 3396篇 |
1998年 | 3234篇 |
1997年 | 2865篇 |
1996年 | 2555篇 |
1995年 | 2182篇 |
1994年 | 2004篇 |
1993年 | 1726篇 |
1992年 | 1477篇 |
1991年 | 1259篇 |
1990年 | 1091篇 |
1989年 | 912篇 |
1988年 | 922篇 |
1987年 | 732篇 |
1986年 | 664篇 |
1985年 | 860篇 |
1984年 | 764篇 |
1983年 | 516篇 |
1982年 | 588篇 |
1981年 | 442篇 |
1980年 | 394篇 |
1979年 | 284篇 |
1978年 | 199篇 |
1977年 | 159篇 |
1976年 | 130篇 |
1975年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 171 毫秒
101.
《Clinical Lymphoma, Myeloma & Leukemia》2020,20(11):720-723
Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia. 相似文献
102.
Mohamed El-Sherbiny Mohamed Ahmed Eladl Anu Vinod Ranade Maha Guimei Hala Gabr 《Singapore medical journal》2020,61(1):39
INTRODUCTIONThis study aimed to investigate the therapeutic response to injected human umbilical cord blood mesenchymal stem cells (UCBMSCs) among albino rats with streptozotocin (STZ)-induced diabetes mellitus.METHODSControl group (GI; n = 25) rats were fed with standard rat diet. Rats with STZ-induced diabetes mellitus without (GII; n = 25) and with (GIII; n = 25) differentiated human UCBMSCs implantation were the test groups. Rats were sacrificed in Week 11 following implantation. Liver biopsies were sectioned and stained in order to highlight both the presence and function of impregnated cells in the liver tissue.RESULTSHaematoxylin and eosin-stained sections in GI and GII rats showed normal liver architecture while GIII rats showed presence of cell clusters inside the liver tissue and around the central veins. Cell clusters with blue cytoplasm were present in sections in GIII rats but absent in GI and GII rats, indicating the presence of injected differentiated human UCBMSCs. The anti-human insulin immunostaining of GIII rats showed clusters of cells within the liver parenchyma and around central veins, indicating that these cells were active and secreting insulin.CONCLUSIONUCBMSCs are proficient in differentiating into insulin-producing cells in vivo under specific conditions and, when transplanted into the liver of albino rats with STZ-induced diabetes mellitus, were able to secrete insulin and partially control the status of diabetes mellitus in rats. 相似文献
103.
104.
105.
106.
《Journal of endodontics》2019,45(7):890-897
IntroductionThe aim was to assess the association of inducible costimulator (ICOS) and ICOS ligand with bone destruction in apical periodontitis (AP).MethodsSpecimens from patients presenting with AP were obtained during apicoectomy and subjected to histopathologic analysis and molecular assessment of ICOS/ICOS ligand. In addition, the experimental AP was induced by exposing the pulp of first mandibular molars of rats. Histologic and radiographic examinations were performed to validate the periapical lesions. The immunolocalization and messenger RNA expression of ICOS/ICOS ligand were evaluated by immunofluorescence staining and quantitative real-time polymerase chain reaction. The osteoclastic activities in periapical lesions, including the lesion size and the expression of tartrate-resistant acid phosphatase and the receptor activator of nuclear factor kappa B ligand, were recorded and followed by correlation analysis with ICOS/ICOS ligand expression.ResultsIn excisional specimens from AP patients, a significantly increased expression of ICOS/ICOS ligand was found compared with the healthy control. In the experimental AP samples, the expression of ICOS/ICOS ligand, tartrate-resistant acid phosphatase, and receptor activator of nuclear factor kappa B ligand was significantly elevated in inflamed periapical tissues (AP group) when compared with the healthy control. The number of ICOS+/ICOS ligand+ cells was highly correlated with the periapical lesion size (r = 0.892, P < .01 and r = 0.930, P < .01, respectively).ConclusionsThe increased expression of ICOS/ICOS ligand in periapical lesions was associated with the inflammatory infiltration and alveolar bone destruction of AP. 相似文献
107.
108.
109.
《Vaccine》2020,38(10):2315-2325
In the preparation of glycoconjugate vaccines in clinical practice, two highly immunogenic carrier proteins, CRM197 and tetanus toxoid (TT), are predominantly conjugated with the capsular polysaccharides (CPSs) of bacterial pathogens. In addition, TT has long been used as an effective vaccine to prevent tetanus. While these carrier proteins play an important role in immunogenicity and vaccine design alike, their defined human major histocompatibility complex class II (MHCII) T cell epitopes are inadequately characterized. In this current work, we use mass spectrometry to identify the peptides from these carrier proteins that are naturally processed and presented by human B cells via MHCII pathway. The MHCII-presented peptides are screened for their T cell stimulation using primary CD4+ T cells from four healthy adult donors. These combined methods reveal a subset of eleven CD4+ T cell epitopes that proliferate and stimulate human T cells with diverse MHCII allelic repertoire. Six of these peptides stand out as potential immunodominant epitopes by responding in three or more donors. Additionally, we provide evidence of these natural epitopes eliciting more significant T cell responses in donors than previously published TT peptides selected from T cell epitope screening. This study serves toward understanding carrier protein immune responses and thus enables the use of these peptides in developing novel knowledge-based vaccines to combat persisting problems in glycoconjugate vaccine design. 相似文献
110.