L-carnitine alleviates sciatic nerve crush injury in rats：functional and electron microscopy assessments

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuro-protective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved signiifcantly. These ifndings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.     

Targeted thrombolysis strategies for neuroprotective effect

Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field.     

Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain

Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. The present study aimed to investigate the analgesic effect of the speciifc sodium-potassium-chloride co-transporter 1 inhibitor bumetanide, and the change in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain. Results showed that intrathecal bumetanide could decrease cumulative pain scores, and could increase thermal and mechanical pain thresholds in a rat model of incisional pain. Sodium-potassium-chloride co-transporter 1 expression in-creased in neurons from dorsal root ganglion and the deep laminae of the ipsilateral dorsal horn following incision. By contrast, potassium-chloride co-transporter 2 expression decreased in neurons of the deep laminae from the ipsilateral dorsal horn. These ifndings suggest that spinal sodium-potassium-chloride co-transporter 1 expression was up-regulated and spinal potassi-um-chloride co-transporter 2 expression was down-regulated following incision. Intrathecal bumetanide has analgesic effects on incisional pain through inhibition of sodium-potassi-um-chloride co-transporter 1.     

婴儿抚触研究进展

从婴儿抚触的概念、生理机制、作用、要求、方法、影响实施的因素等多个方面，综述了婴儿抚触的研究进展。     

下牙槽神经相关神经肽及其非神经传导功能

下牙槽神经作为一种混合神经,不仅可以通过外感受器发挥神经传导功能,而且还可通过释放神经肽发挥其非神经传导功能。神经肽是一类由神经细胞合成并释放,通过细胞外的受体对目标细胞发挥调节作用的生物活性多肽,与下牙槽神经相关的神经肽主要有P物质、降钙素基因相关肽、神经肽Y和神经激肽A等。下牙槽神经可以通过释放这些神经肽调节牙体发育及神经源性炎症,维持体内免疫稳态、促进骨折愈合,在组织的修复再生中起重要作用。通过对下牙槽神经非传导作用的研究,进一步从分子、细胞及组织多层面探讨神经与组织再生间的关系,揭示神经因素在促进组织再生并提高其再生质量等方面的作用,将成为未来重要的研究方向。本文将就下牙槽神经及其非神经传导作用作一综述。     

肝素辅助治疗小儿哮喘30例疗效观察

临床发现具有低抗凝作用活性的肝素及其衍生物在影响黏着力、活化和白细胞转运控制炎症等方面表现有一定程度的生物多样性。作者自2001年以来，用肝素辅助治疗小儿哮喘30例，现报告如下。     

影响护生临床实习角色转变的原因及对策

目的：使护生顺利完成角色转变。方法：影响护生角色转换的因素进行分析。结果：发现生源素质、心理因素、缺乏沟通技巧等原因影响护生角色转变。结论：加强岗前培训,改变带教方法可促进护生角色转换。     

以护理学基础为例浅谈青年专业教师在双语教学中的作用

双语教学在各高校陆续开展，其中师资问题一直是影响双语教学的关键因素。青年专业教师具有良好的英语基础和专业基础，有较高的内在因素和较强的创新能力，有助于高等院校双语教学快速开展。本文就以护理学基础为例对青年教师在双语教学中的作用进行了探讨。     

胰岛素样生长因子系统与运动系统的关系研究进展

胰岛素样生长因子系统（insulin-like growth factor.IGFs）是一个复杂的体系，其构成主要包括：IGF-Ⅰ、IGF-Ⅱ、IGFBPI-6（骨骼组织主要为IGFBP3-5）、IGF-IR，酸不稳定亚单位等成分。许多组织、细胞在不同的发育阶段都有IGF-Ⅰ和IGF-Ⅱ的表达，而骨骼是除了肝脏之外血IGFs的第二大来源。IGFs生物学作用广泛，不仅能模拟生长素的一些生物学效应，同时也具有类似胰岛素的代谢活性，对多个器官组织有生物学功能。     

矩阵针灸治疗中枢性偏瘫患者的康复疗效分析

本对２０例中枢性偏瘫患进行了以头部矩阵针灸为主的的康复治疗，总有效率达９５％。其中治愈率为３５％，显效率为３５％，好转率为２５％，无效率为５％。在治疗中我们发现，由于头部矩阵针刺的良性剌激直接作用于脑部，对患的智能康复有明显的治疗作用。