38例炎性肠病的药物治疗

炎症性肠病（IBU）本病包括克罗恩病（CD）和非特异性溃疡性结肠炎（UC）。溃结（UC）病因虽未完全阐明，但多数学者认为与遗传因素、免疫功能障碍、感染及精神因素有关。现将38例炎症性肠病的药物治疗介绍如下。     

肾囊肿先天遗传,中年闹事

近来,有一位48岁男性患者,因尿少、浮肿、纳差,求治专家门诊。当我查体时,发现他左上腹触及梨状圆形肿物后,马上予以B超检查,发现双侧多囊肾、左肾呈8×10厘米大小,伴有多囊肝。急查尿素氮后诊断为多囊肝合并多囊肾;继发慢性肾功能衰竭。肾囊肿性疾病是以肾脏出现内覆上皮细胞囊肿为特征的囊性疾病,是一种良性疾病。但是,重者也可引发不良的后果。囊肿可有单个或多个,内含液体或半固体碎片,多为先天遗传性,少数也可为后天获得性。男女都可患病,发生率0.2%。通常有以下几种情况:多囊肾是一种先天性异常,多为双侧性多发性囊肿。成人发展缓慢,…     

Ⅰ、Ⅱ相代谢酶基因多态性与苯遗传易感性的关系(综述)

苯是一种良好的有机溶剂,但人体长期接触苯可引起造血系统的损害。个体对苯致血液毒性的易感性存在着差异,个体易感性与基因的遗传多态性、环境暴露情况、年龄、营养状况等因素有关。出现基因多态性的原因可以是单核苷酸变异, 或是某些高度重复序列的考贝数变异。目前,国际、国内关于苯的个体易感性主要是关于代谢类型和代谢酶基因多态性的研究。     

卡巴胆碱对烧伤延迟复苏大鼠免疫功能的影响

Objective To explore the changing trend of Ia on monocyte, lymphocyte apoptosis rate, TNF-α and IL-6 in abdominal aorta of burned rats with delayed resuscitation and the influence of application of carbachol on them. Methods Adult male Wistar rats were randomly divided into normal control group(n =8), scald group(n =48) and scald with carbachol treatment group(n =48). In latter two groups, rats were inflicted with 30% total body surface area (TBSA) full-thickness scald and delayed fluid resuscitation. All scald rats were sacrificed at the 6th hours or 1st, 2nd, 3rd, 7th, 14th day after scald, with 8 rats at each time point. Expression of Ia antigen on monocyte and lymphocyte apoptosis rate were determined by direct immunofluorescence on a flow cytometer, and TNF-α and IL-6 was measured by ELISA. Results Expression of la on monocyte was obviously lower than that of controls. The lowest levels were recorded on the 6th hours and 1st day after scald. Subsequently, Ia was elevated gradually, but still lower than that of normal rats(P <0. 01). After administration of carbachol, Ia expression was obviously promoted, compared with the simple scald group (P <0. 01). Lymphocyte apoptosis rate, TNF-α and IL-6 was higher than that of controls(P <0. 01). After administration of cavachol, , lymphocyte apoptosis rate and TNF-α and IL-6 was obviously down-regulated on the 6th hours, 1st day, 2nd day and 3rd day after scald injury, compared with the simple scald group (P < 0. 01 or 0. 05). Conclusion After severe burn with delayed fluid resuscitation, there is a low la expression, high lymphocyte apoptosis rate and increased releasing of proinflammatory cytokine. Immune function was suppressed. Carbacho] could improve the immune function of scald rats with delayed fluid resuscitation.     

VEGF对缺血/再灌注损伤胰腺细胞凋亡的影响

目的 研究血管内皮生长因子(VEGF)对缺血/再灌注损伤胰腺组织细胞凋亡的影响.方法 将雄性sD大鼠30只随机分为3组(n=10),A组为假手术组,B组为缺血/再灌注损伤组,C组为缺血/再灌注损伤+VEGF反义寡核苷酸组.通过血管夹阻断大鼠腹腔干及肠系膜上动脉30 min,然后去除血管夹再灌注6 h,建立大鼠胰腺缺血/再灌注损伤模型.对各组胰腺组织进行VEGF免疫组化染色及TUNEL法细胞凋亡检测.结果 缺血/再灌注损伤后胰腺组织出现细胞凋亡,同时VEGF蛋白表达上调.缺血/再灌注损伤+VEGF反义寡核苷酸组的胰腺组织VEGF蛋白表达较缺血/再灌注损伤组显著减少(P<0.05),前者细胞凋亡指数较后者明显升高(P<0.05).结论 VEGF能抑制缺血/再灌注损伤胰腺细胞凋亡,可能对胰腺缺血再灌注损伤具有保护作用.     

血管内皮生长因子基因多态性与子宫内膜异位症和子宫腺肌病发病风险的关联研究

子宫内膜异位症(内异症)和子宫腺肌病(腺肌病)为妇科常见疾病,但其病因及发病机制尚不明确.虽为良性疾病,但具有周围浸润、远处转移和种植的恶性行为,其中血管生成在子宫内膜异位种植的过程中起重要作用.     

YES OR NO

手机辐射能破坏人类遗传；躺着是最佳的思考方式；开灯睡觉增强免疫力；多饮奶制品 易患前列腺癌；运动过度会变笨。     

家族遗传性骨软骨瘤3例报告

骨软骨瘤病的诊断临床主要依据X线摄片，工作中笔者遇到一对父子因外伤来院就诊，经拍片发现父子均患有多发性骨软骨瘤病，联想到可能有家族遗传性，随之邀请其老人来检查，经检查发现亦患有多发性骨软骨瘤病，表现均典型，现介绍如下。     

神经干细胞移植治疗不治之症

肌萎缩脊髓侧索硬化是一种神经系统运动神经元细胞逐渐退化死亡的疾病，大多数病人发生于20-80岁之间，平均57岁，男性多于女性。一般而言，从症状开始发生到死亡大约为2～5年。患大多从一侧肢体起病，继而发展为双侧。临床表现为四肢肌肉逐渐萎缩、无力，直至瘫痪。晚期病人容易发生呼吸衰竭和吞咽困难，最终因肺部感染，病情迅速恶化，全身肌肉极度萎缩，痛苦而终。发病原因尚不完全明确，其中有5％-10％的病例具有家族遗传倾向。     

前癃通胶囊对体外培养基质细胞TGF-β1表达干预作用的研究

目的:探讨前癃通胶囊对体外培养人前列腺基质细胞TGF-β1表达的干预作用.方法:分离、培养人的前列腺增生基质细胞,同时分别加3种剂量前癃通胶囊(水溶液),利用逆转录-多聚酶链反应(RT-PCR)方法,观察TGF-β1在基质细胞中的mRNA表达.结果:细胞空白对照组TGF-β1mRNA的表达最高,而高剂量前癃通胶囊(药液)TGF-β1mRNA的表达最低.与细胞空白组比较(P＜0.01),高剂量组和中剂量组TGF-β1的表达明显减弱(P＜0.05,P＜0.01),但低剂量组无明显差异(P＞0.05).结论:前癃通胶囊能抑制前列腺基质细胞中TGF-β1mRNA的表达,这可能是前癃通胶囊治疗前列腺增生作用的主要机制之一.