老年急性心肌梗死患者T淋巴细胞亚群与SIL—2R的检测

以间接免疫荧光法、单克隆与多克隆双抗体夹心法测定了２０例老年急性心肌梗死患者及健康老人外周血Ｔ细胞亚群、可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）的水平，发现老年急性心肌梗死组ＯＫＴ３、ＯＫＴ４、ＯＫＴ８水平显著降低，ＯＫＴ４／ＯＫＴ８与ＳＩＬ－２Ｒ水平则明显升高，提示老年急性心肌梗死患者Ｔ细胞亚群变化与ＳＩＬ－２Ｒ水平有一定关系。     

香菇多糖注射液对慢性乙型肝炎外周血单个核细胞膜IL—2受体表达的影响

The effects of lentinan on peripheral blood mononuclear cell (PBMC) expression of IL-2 receptor in patients with chronic hepatitis B in vitro and in vivo were studied. The expression percentage of IL-2 receptor in 44 patients with chronic hepatitis before treatment was 36.74 +/- 7.74, which was lower than healthy subjects, and was 48.92 +/- 3.79 after 2 months treatment of lentinan, which was approximated the normal control. PBMC from 30 patients with chronic hepatitis B were cultured in vitro with or without lentinan. The percentage of expression IL-2 receptor was 12.81 +/- 2.62 without lentinan and was 35.70 +/- 4.87 in the presence of lentinan. The concentration of lentinan stimulating expression of IL-2 receptor was between 0.2 to 200 g.ml-1. The results suggest that lentinan stimulates expression of IL-2 receptor on PBMC, which is associated with the therapeutic effectiveness of lentinan treatment.     

饥饿大鼠胰岛胰高血糖素和嗜铬颗粒素A变化的定量免疫组织化学研究

用免疫组织化学ＡＢＣ法结合图像分析技术，研究饥饿状态下大鼠胰岛胰高血糖素（ｇｌｕｃａｇｏｎ，Ｇｌｕ）和嗜铬颗粒素Ａ（ｃｈｒｏｍｏｇｒａｎｉｎＡ，ＣｇＡ）的含量变化。结果表明，与正常对照组相比，饥饿大鼠胰岛Ａ细胞中Ｇｌｕ含量明显下降，ＣｇＡ含量仅在饥饿５ｄ后显著下降。这提示饥饿可导致Ｇｌｕ释放快速增加，而ＣｇＡ释放增加却较为缓慢。与饥饿５ｄ大鼠组相比较，饥饿５ｄ后静脉注射葡萄糖（１ｇ／ｋｇ体重）９０ｍｉｎ后胰岛Ａ细胞内Ｇｌｕ含量明显升高，ＣｇＡ含量无显著变化。提示静脉注射葡萄糖可作用于胰岛Ａ细胞，使Ｇｌｕ释放快速减少，但对ＣｇＡ的释放无影响。以上结果表明，外源性葡萄糖对胰岛Ａ细胞中Ｇｌｕ和ＣｇＡ两种物质的作用机制不同，为进一步阐明胰岛内Ｇｌｕ和ＣｇＡ的不同生理作用提供了形态学依据。     

十八例颅脑外伤所致精神障碍临床分析

本文对符合CCMD-2诊断标准的18例颅脑外伤性精神障碍进行临床分析，发现具有男性，五人，性格急躁好胜等要素的占多数，受伤原因以工作意外为多，诊断上以颅脑外伤所致精神病为多。本文并对上述结果及颅脑外伤与精神障碍的关系进行简略的讨论。     

HER-2/neu原癌基因与人类癌症

HER－2／neu（C－erb－B－2）原癌基因编码185kD蛋白质，其结构与表皮生长因子受体（EGFR）具有广泛的同源性，也是具有酪氨酸蛋白淑游活性的持定生长因子的受体。HER－2／neu原癌基因可通过点突变扩增及过量表达激活，而且与多种人类病症的恶性有关，可以作为新的抗癌疗法的靶子。