抑肽酶预处理防护大鼠肝脏缺血再灌注损伤的实验研究

目的 探讨抑肽酶预处理对肝脏缺血再灌注损伤的防护作用。方法 SD大鼠80只，随机分为抑肽酶预处理和生理盐水预处理两组，观察肝脏缺血再灌注损伤引起及抑肽酶预处理的影响。结果 拟肽酶预处理组大鼠缺血再灌注损伤引起的血清谷丙转氨酶（ALT），谷草转氨酶（AST）活性及肝组织丙二醛（MDA）含量变化均显著低于生理盐水预处理组（P＜0．01）；肝细胞形态学异常改变也明显较生理盐水预处理组轻。结论 抑肽酶预处理对大鼠肝脏缺血再灌注损伤有明显的防治作用。     

组织特异性胞嘧啶脱氨酶和5-氟胞嘧啶热化疗对裸鼠结肠癌肝脏转移的影响

Objective To investigate the effects of tissue specific cytosine deaminase/5-fluorocytosine (CD/5-FC) thermotherapy on hepatic metastasis of colonic carcinoma in nude mice. Methods Forty-five nude mice were randomly divided into control group, 5-FC group and 5-FC thermotherapy group according to the random number table (15 mice in each group). Mice models of hepatic metastasis of colonic carcinoma were established by portal vein injection of LoVo/CEACD cells. The hepatic metastasis rate and number of metastatic nodules of the 3 groups were compared by ehi-square test and one-way ANOVA. The pathological changes in tumor tissues and apoptotic index of tumor cells were observed. The expression of the CD gene in tumor tissues was detected by fluorescent quantitative RT-PCR and Western blot. Results The number of metastatic nodules and liver metas-tasis rate were 4.6±1.3 and 100.0% in control group, 2.2±1.0 and 60.0% in 5-FC group, 0.5±0.8 and 13.3% in 5-FC thermotherapy group, with statistical difference among the 3 groups (F=25.898, χ2=5.208, 19.548, 5.168, P<0.05). The mean apoptotic indexes of tumor cells of the 3 groups were 4.6%, 9.9% and 17.4%, respectively. Vacuolar degeneration, cell necrosis, cytolysis and apoptotic bodies were mostly observed in the 5-FC thermotherapy group. The expression of CD gene in tumor tissue was detected in all the groups. Conclusion Tissue specific CD/5-FC thermotherapy has inhibitory effects on the hepatic metastasis of LoVo cells transfected with CD gene.     

找回自然健康的睡眠

1.湖北建筑师李先生问:现在褪黑素产品很多,睡眠康宁含片跟其他产品有什么不同?答:市面上褪黑素类产品都是吞服片剂、胶囊、水剂等,服用后首先进入肠胃、肝脏代谢,大部分被分解而失效(肝脏首过效应)。而睡眠康     

肝脏全面护理，健康永远相随

肝脏是人体最重要脏器之一,肝脏好坏直接影响到人的健康和寿命。肝脏是人体内新陈代谢最活跃的器官,它具有调解血液、解毒,参与体内糖类、蛋白质和脂肪代谢的功能,对免疫、凝血、热量产生及电解     

肝脏病会议上涌现许多丙型肝炎药物

在旧金山召开的美国肝脏病研究学会会议上涌现出许多丙型肝炎潜在治疗药物，特别是那些对难治患者有希望的药物。     

同时拉升血压和血糖的黑手——嗜铭细胞瘤

随着生活水平的提高，国人的糖尿病发病率越来越高，给人们的健康生活蒙上了一层厚厚的阴影。然而，高血糖并非糖尿病的专利，有很多器官的疾病也可以合并血糖升高，比如肝脏疾病、胰腺疾病、甲状腺疾病、肾上腺疾病等。今天要给大家介绍的是一种叫嗜铬细胞瘤的疾病，它也可以造成血糖的异常升高。     

20例肝脏疾病并发胸腹水治疗体会

肝脏痰病导致胸腹腔积液，临床治疗胸腹积液以护肝、利尿、限钠、限水、补充营养、抗感染等内科综合治疗，20例患者16例胸腹水得到控制而逐渐吸收，有效率占80％，4例肝功能衰竭合并全身多器官衰竭而死亡占20％。抽胸腔积液配合内科综合治疗是改善和治疗肝脏疾病并发胸腹水的主要治疗手段。     

浅谈肝炎病人的饮食休息指导

肝脏是人体最大的消化器官，蛋白质、脂肪及碳水化合物进入人体后，都要由肠道吸收进入肝脏，在肝内经过代谢，合成营养物质后．才能被人体所利用，如果饮食不当和休息不好或劳累过度都会增加肝脏负担，影响疾病的恢复。