熊去氧胆酸联合复方甘草甜素治疗原发性胆汁性肝硬化

原发性胆汁性肝硬化是一种慢性非化脓性、肉芽肿性胆管炎,主要影响中等大小的肝内胆管,特别是肝内小叶间胆管.血清碱性磷酸酶、谷氨酰转肽酶升高,抗线粒体(AMA)抗体阳性是本病的重要特征.     

2例大剂量肾上腺素复苏成功报告

病例1：男性患者，52岁，因剧烈心前区痛放射至左上肢3h来诊．既往有高血压、冠心病史．间断服用降压药。查体：神清，生命指征正常，ECG示：急性广泛前壁心机梗死。立即给予吸氧、舌下含服硝酸甘油0．5mg、肌肉注射度冷丁50mg、建立静脉通路。患者突然出现意识丧失、全身抽搐、呼吸及大动脉搏动消失．BP0／0kPa，心电监护示：心室颤动。立即行面罩给氧．同时胸外心脏按压，     

冠心病药膳几款

冠心病(全称为“冠状动脉粥样硬化性心脏病”)是冠状动脉发生粥样硬化后引起的心脏疾病。严重时可引起狭窄或阻塞,或在此基础上合并痉挛及血栓,从而导致冠状动脉严重阻塞,引起供血不足,形成心肌缺氧导致梗塞或坏死,造成严重后果。冠心病成因中,饮食失调占重要地位。主要是过食肥腻,运动过少,使痰瘀阻于胸中而成“胸痹”;胸阳不振,气血运行不畅,所以胸痛彻背,闷胀欲死。除了服用甘油三酯类的止痛药之外,药膳的调理也可起到很好的作用。兹介绍数款:山楂饮原料与用法:山楂60g,白糖15g。山楂洗净,放入锅中,加水适量,置旺火烧沸,继熬30分钟,滤渣…     

穿刺加三苯氧胺治疗乳腺囊肿的疗效观察(附36例)

目的：比较乳腺可扪及囊肿穿刺抽液后服用三苯氧胺和单纯穿刺抽液两种治疗方法的疗效.方法：将临床可扪及乳腺囊肿根据乳腺B超检查结果入组68例,随机分为穿刺抽液治疗组32例和穿刺抽液后服三苯氧胺治疗组36例,两组患者穿刺抽液后中位随访13个月观察疗效.结果：68例可扪及乳腺单纯囊肿,平均囊肿大小23mm,36例穿刺服三苯氧胺组复发率13.89%（5/36）,32例穿刺抽液组复发率37.50%（12/32）,两组相比较（P＜0.05）有显著性差异.乳腺囊肿病史＞1年的患者,穿刺服三苯氧胺组和穿刺组复发率分别是36.36%（4/11）和77.78%（7/9）,两组相比较（P＜0.05）差异有显著性.对单个囊肿,多发囊肿,囊肿病史＜1年患者,两种治疗方法不影响复发率（P＞0.05）.结论：临床可扪及乳腺单纯囊肿可根据B超检查筛选适合穿刺患者,穿刺抽液加服三苯氧胺治疗可减少复发,囊肿病史＞1年者复发率较高.     

高原地区电视胸腔镜手术临床应用

目的探讨电视胸腔镜手术诊断和治疗高原地区胸内各种疾病及其优越性。方法采用电视胸腔镜下手术，必要时胸腔镜辅助小切口对胸腔积液、脓胸、自发性气胸、肺包虫病、胸外伤等疾病在全身麻醉双腔气管插管单肺通气下进行手术。结果单纯胸腔镜下完成手术6例，占46％；胸腔镜辅助小切口完成手术5例，占38％；中转开胸手术2例，占15％。手术时间60．198min，平均123min。带引流管时间4—15天，平均8天。术后住院时间8—23天，平均15天。术后并发肺泡漏气伴患肺叶不张1例，无手术死亡及大出血等并发症发生。结论电视胸腔镜手术在高原缺氧地区的临床应用同样安全、有效并具有其优越性。     

FasL基因表达对缺氧状态下直肠癌细胞增殖凋亡的影响

Objective To elucidate the effect of FasL gene expression on the proliferation and apoptosis of hypoxic rectal carcinoma cells. Methods The normoxic expression level of FasL in HR-8348 subtype cells (HR-8348B, HR-8348L, HR-8348F and HR-8348As) with different invasive power were verified by Western blot. Hypoxia models for HR-8348B, HR-8348L, HR-8348F and HR-8348As were constructed with chemical modeling, then the FasL levels in all groups at 12 h after hypoxia were quantitated by Western blot. Distribution of different cell life cycles was determined with flow cytometry. Cell reproductive activities were detected with MTT method, and cell apoptesis was assessed with TUNEL. Results FasL protein was pigmentized at the position of 40 000 by Western blot, and the expression level of FasL was significantly higher in HR-8348F cells than those in HR-8348B, HR-8348L and HR-8348As cells(F=361.149, P<0.01) in normoxia. At 12 h after hypoxia, the FasL level was also significantly higher in HR-8348F cells than those in other groups (F=278.766, P<0.01), but was not markedly different as compared to themselves in normoxia (t=1.762, P>0.05). The proliferation index was significantly higher in HR-8348F (60.43±3.72) than those in HR-8348B (40.01±3.30), HR-8348L (41.30±4.06) and HR-8348As cells (35.87±4.39), respectively (F=39.477, P<0.01). However, both inhibition rate of proliferation and apoptotic index were remarkably lower in HR-8348F (17.30±1.98 and 13.10±1.04) than those in HR-834B (33.70±4.33 and 21.60±1.31), HR-8348L (34.20±3.92 and 20.10±1.15), and HR-8348As (38.00±4.55 and 23.90±1.23), respectively (F=28.811 and 76.462, respectively, P<0.01). Conclusion The expression enhancement of intracellular FasL in rectal carcinoma in hypoxia can lead to accelerated proliferation and reduced apeptosis of cells, which will promote tumor cells to adapt microenvironmental hypoxia.     

高氧液对急性重型颅脑损伤氧分压、氧饱和度的影响

一、资料与方法1.临床资料:男31例,女9例,年龄16-83岁,平均(50.5±12.3)岁。车祸伤36例,坠落伤2例,打击伤2例。入选标准:(1)伤后12h入院;(2)GCS≤8分;(3)未合并颅外其他脏器的损伤;(4)无低血压。观察其间病人气管插管9例、共19d,气管切开5例,共14d,机械辅助呼吸6例,共21d。     

聚环氧氯丙烷／液晶复合富氧膜的研究

研究了聚环氧氯丙烷(PECHCH)/N(4-乙氧基苄叉)4-丁基苯胺(EBBA)复合膜对氧气和氮气的透过性和选择性。用示差扫描量热计(DSC)、解偏振光强仪(DLI和偏光显微镜考察了复合膜的形态结构。结果表明,当PECH/EBBA复合膜处于液晶的向列相转变温度时,有较高的气体透过性和选择性。发现只有复合膜中EBBA含量在30wt％以上,PECH和EBBA呈非均相混合时,才有较明显的富氧效果。当EBBA含量达50wt%时,氧氮分离系数α=3.78。     

《内经》五行胜复的思维模式新探

五行胜复，又称“子复母仇”；载于《内经》，以《至真要大论》为代表。今就其概念、特点、模式和应用加以研讨。并指出五行胜复的实质是恢复五行之间亢害承制关系．以维系人体五行系统相对平衡，它体现了传统文化的二、五思维模式。