血透患者中枸橼酸西地那非的药代动力学及血流动力学变化

患有肾病的男性中ED发病率很高。枸橼酸西地那非是勃起功能障碍的高效治疗药物，严重肾功能不全会使该药清除率下降，但在血透治疗的终末期肾病患者中，该药的药代动力学和血液动力学研究尚未见报导。为了研究血透患者中，该药的药代动力学和血流动力学变化，Grossman EB等人让15例慢性门诊血透维持患者在血透前2h及血透后2h口服单剂西地那非，先服哪一次进行随机分配确定。     

国产促动力药物治疗功能性消化不良的成本-效果分析

目的　评价不同药物治疗功能性消化不良的经济效果。方法　运用经济学中的成本 -效果分析方法 ,对莫沙必利、伊托必利和吗丁啉治疗功能性消化不良方案进行分析。结果　莫沙必利与吗丁啉成本效果比相当 ,但所需增长的成本效果比高 ;伊托必利的成本效果比和增长的成本效果比均高于吗丁啉。结论　吗丁啉是治疗功能性消化不良的最佳用药方案     

法莫替丁、莫沙必利、达喜合用治疗反流性食管炎36例疗效观察

反流性食管炎(reflux esophagitis，RE)是一种食管反流病，由胃和十二指肠内容物，主要是酸性胃液或酸性胃液加胆汁反流至食管所致的食管黏膜炎症、糜烂、溃疡和纤维化等病变。主要症状有烧心、胸痛、吞咽困难、反酸等表现。我们采用法莫替丁、莫沙必利、达喜联合应用治疗反流性食管炎取得了满意疗效，现报道如下。     

云南白药联合莫沙必利、奥美拉唑治疗反流性食管炎

反流性食管炎是由于下食管括约肌运动障碍或胃食管连接部结构异常,胃十二指肠内容物反流入食管,引起食管黏膜的化学炎症,主要临床表现为:反酸、反食、烧心、胸痛、吞咽困难及咽喉症状.     

莫沙必利联合多塞平治疗功能性消化不良疗效观察

功能性消化不良(FD)是临床常见的症候群,本病占内科患者数10%以上,占消化科门诊患者的50%[1]。部分患者存在胃动力异常并与精神因素有关。我院2000年以来观察莫沙必利联合多塞平(多虑平)治疗FD的疗效,现报道如下:     

吃醋有学问

如今，流行“饮醋健康法”，甚至还成为一股热潮，喝醋被认为可以美容防皱，迅速消除疲劳、防止疾病。醋疗法因此赢得众多女士的青睐。     

多潘立酮在增强结肠运动中的作用

Objective To observe the prokinetic effect of domperidone on colon and compare with that of mosapride and cisapride.Methods ① In viva experiment:forty rats were divided into control,domperidone,mosapride,and cisapride groups with 10 in each group.Stran gauges were planted both in proximal and distal colons and colonic motor activities were recoded in conscious rats.② In vitro experiment:the prokinetics effects of dopamine or dopamine combined with domperidone on the contraction of isolated rat colon strips were recorded by tone-transducers in the thermostatic muscle bath.Results In viva experiments:① in the interdigestive period of resting,activities of rhythimic phasic contraction were recoded in colon at conscious rats,and ② it had been showed that dornperidone significantly enhanced the contraction of colon in dose-dependent manner.Compared with control group,the mean contraction amplitude of proximal colon and distal colon increased by 84.61% ± 7.26% and 76.37 % ± 8.47% in domeridone group,respectively,which was higher than those in mosapride group (50.32%±8.16% and 45.13%±7.16%,respectively),but as same as those in cisapride group (92.55% ± 8.37% and 81.27% ± 9.95%,respectively).In vitro experiments:① perfusion of dopamin (40 mg/ml) could significantly decrease the contraction of isolated colon strip by 91.56% ± 10.24% in comparison with Krebs-Ringer solution,and ① domperidone could block the relaxant effect of dopamin on the isolated colon strip.Conclusions Domperidone can significantly enhance the colonic motor activities via antidopaminergic action.The effects of domperidone are similar as eisapride and greater than mosapride.     

枸橼酸西地那非对于接受β受体阻滞剂治疗的心绞痛患者心肌缺血的影响

有报道称磷酸二酯酶5(PDE_5)抑制具有潜在危害,而且可以增加冠状动脉疾病患者心脏事件的风险。Patrizi R等人进行了一项评价PDE-5抑制剂是否会对接受β受体阻滞剂治疗的患者心肌缺血产生影响。研究中,14名患者无治疗下接受基线运动试验,然后开始氨酰心安治疗(100mg,1d/次)。入组一周后,接受第二次运动试验,隔两天后按不同的两种情况以随机方式