真菌性肺炎误诊1例

近年来，由于广谱抗菌素及肾上腺皮质激素的广泛应用，真菌感染的发病率急剧增加，且病死率高，已引起高度重视。现将我科确诊的真菌性肺炎患者1例报告如下。     

术中区域性高浓度抗生素预防感染的研究

采用局部组织注射金黄色葡萄球菌制成创伤感染模型。实验组术中区域性高浓度注射抗生素，预防家兔肢体远端创伤后感染。对照组作为常规治疗。结果实验组无一肢体发生感染，对照组组织细菌培养有细菌生长，病理切片示急性炎性反应，且可见小脓肿。     

脑干听觉诱发电位监测奈替米星对新生儿耳毒性反应

奈替米星（Netilmicin）又称硫酸乙基西梭霉素。是一种半合成、水溶性氨基甙类抗生素。由于它对第对颅神经的损害，可致永久性耳聋，使临床使用受到限制。为此，我们利用脑子听觉诱发电位（BAEP）对使用奈替米星治疗的新生儿进行监测，观察其对新生儿听觉通路的影响。1资料与方法1．1收集1997年4月～1997年7月我院新生儿病区住院的符合以下条件的40例新生儿肺炎：（1）足月儿；（2）无新生儿窒息、黄值；（3）除外其它中枢神经系统疾患（如颅内出血、缺氧缺血性脑病等），无神经系统症状；（4）无耳聋家族史，妊娠期间母亲未用任何耳毒性…     

医院感染与抗生素的应用

医院感染与抗生素的应用中国医学科学院中国协和医科大学北京协和医院加强医疗科（１００７３０）杜斌陈德昌医院感染（ｎｏｓｏｃｏｍｉａｌｉｎｆｅｃｔｉｏｎ）是当前重要的公共卫生问题之一［１］。根据美国疾病控制中心（ＣＤＣ）于１９８８年提出的定义，医院感染是...     

静脉输注双黄连致过敏性休克1例

患，女，68岁，因感冒引起发饶、咳嗽、心慌气短，曾在乡卫生院输注抗菌素类药物，病情不见好转，于1997年9月16日入住我院。     

误药救逆四则

一血虚发热张×儿媳,24岁,1963年孟秋分娩,一胎双男,数日后忽高热神昏,恶露不绝,腹不痛,注射抗菌素无效,乃改请中医。症见:舌苔淡黄,脉象浮大,面红耳赤,大便不行,余不顾产后血虚,迳予黄芩汤以撤其热,服后身踡肢厥,双脉几伏,后来竟至覆被蒙首,寒战(齿介)齿。     

β-内酰胺族抗菌素的研究——Ⅲ.7-脒硫乙酰胺基头孢菌素酸亚砜衍生物的立体定向合成

为寻找更有效的新头孢菌素衍生物,本文报道了具脒硫基侧链的头孢菌素酸(R)和(S)型亚砜的立体定向合成。(S)-型亚砜衍生物II-(S)系将化合物V直接用过酸氧化,再与各种取代硫脲缩合而得。若将7-ACA转化为Schiff碱再行氧化则可立体定向地合成(R)-型亚砜Ⅶ,继而水解,酰化得Ⅸ。最后与各种取代硫脲缩合可得(R)-亚砜衍生物Ⅱ-(R)。所得各中间体及产物的立体化学均经₁H核磁共振予以证实。     

Antitumor effects of interleukin-18 gene-modified hepatocyte cell line on implanted liver carcinoma

Objective To investigate the antitumor effects of intrasplenically transplanted interleukin-18 (IL-18) gene-modified hepatocytes on murine implanted liver carcinoma. Methods Embryonic murine hepatocyte cell line (BNL-CL2) was transfected with a recombinant adenovirus encoding IL-18 and used as delivery cells for IL-18 gene transfer. Two cell lines, BNL-LacZ and BNL-CL2, were used as controls. One week after intrasplenic injection of C26 cells (colon carcinoma line), tumor-bearing syngeneic mice underwent the intrasplenic transplantation of IL-18 gene-modified hepatocyte cell line and were divided into treatment group (BNL IL-18) and control groups (BNL-LacZ and BNL-CL2 ). Two weeks later, the serum levels of IL-18, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in the implanted liver carcinoma-bearing mice were assayed, the cytotoxicity of murine splenic cytotoxic T-lymphocytes (CTLs) was measured, and the morphology of the hepatic tumors was studied to evaluate the antitumor effects of the approach. Results In the treatment group, the serum levels of IL-18, IFN-γ, TNF-α and NO increased significantly. The splenic CTL activity increased markedly (P<0.01) , accompanied by a substantial decrease in tumor volume and the percentage of tumor area and prolonged survival of liver carcinomo-being mice. Conclusions In vivo IL-18 expression by ex vivo manipulated cells with IL-18 recombinant adenovirus is able to exert potent antitumor effects by inducing a predominantly T-cell-helper type 1 (Th1) immune response. Intrasplenic transplantation of adenovirus-mediated IL-18 gene-modified hepatocytes could be used as a targeting treatment for implanted liver carcinoma.