Harmful Effects of MSG on Function of Hypothalamus—Pituitary—Target Gland System

It has been demonstrated that neonatal administration of monosodium glutamate(MSG)results in a clearly defined lesion of the arcuate nucleus(AN)of the hypothalamus.The present study shows that fat was accumulated in the abdomen of male rats treated with MSG;weights of the body,pituitary and testis were lower;β-EP content in hypothalamus decreased while L-EnK content increased;serum LH,FSH,TSH,GH and TS levels all decreased in varying degrees while serum PRL level significantly increased.The cAMP content lowered in pituitary,but nor in testes;clear histological changes occurred in testicular tissue;Se-GSH-Px activity in both testis and adrenal gland lowered while LPO level significantly increased.Both Se-GSH-Px activity and LPO level in liver increased.These results indicate that MSG is harmful to the function of the hypothalamus-pituitarytarget system of neonatal rats.     

微创血肿碎吸术治疗高血压脑出血200例分析

高血压脑出血是神经内科急危重症，死亡率及致残率高，我们从1997年至今采用YL—l型颅内血肿粉碎穿刺针，治疗高血压脑出血200例。结果：血肿清除情况，首次清除率：29．5-82．5％，平均为31．7％，总清除率60．2％-91．3％，平均约为84．1％，死亡率：治疗组为17％，明显低于对照组54％，再出血发生率，治疗组为8％，对照组为7．1％，两组相比无明显差异，神经功能恢复情况：治疗组166例中ADLI—Ⅲ级为106例，对照组32例，仅有5例，两组相比有显著差异(P＜0．01)。讨论：高血压性脑出血引起的神经损伤常由于血肿的占位效应，造成脑组织直接受损以及血肿周围脑组织水肿引起的继发性脑损伤。我们治疗病例大部分在6小时。3天内，而再出血机率为8％，与内科保守治疗7．1％无明显差异，因此我们倾向早期穿刺手术，较安全疗效好，总之，微创手术操作简单，易于掌握，要求条件简单，适合高血压脑出血患者的治疗，又易在基层医院开展。     

1例肾移植患者血清中sIL—2R水平的动态观察

检测了１例肾移植患者血清中可溶性白细胞介素－２受体的动态水平。结果显示，ｓＩＬ－２Ｒ可作为肾移植排斥反应的监指标。     

大鼠马桑内酯急性局灶型癫痫大脑运动皮质的形态计量研究

用微量马桑内酯注入Ｗｉｓｔａｒ大鼠左侧前肢运动皮质，造成急性局灶型癫痫。用光镜、电镜和体视学方法研究其运动皮质第Ｖ层结构的改变。结果显示：癫痫大鼠运动皮质灶区、灶旁区的神经细胞数和胶质细胞数均分别比对照大鼠灶区和灶旁区显著减少；灶区神经毡中突触性终末数，显著减少；突触性终末的面积分数明显减少，而树突的面积分数无变化；神经胶质突起的面积分数增加。     

连续静-静脉血液滤过抢救重症急性肾衰竭伴多器官功能障碍综合征20例

1引言 重症急性肾衰竭(急性肾衰)是内科危重病之一,传统的治疗方法病死率高,如急性肾衰伴多器官功能障碍综合征(MODS)则病死率更高.我院运用连续静-静脉血液滤过(CVVH)共抢救重症急性肾衰伴MODS患者20例.疗效可靠,现报告如下.