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Plasma rich platelets (PRP) consist of blood plasma with a high concentration of platelets autologous constituting a huge reservoir of growth factors. The clinical use of the PRP is widespread in various medical applications. Even it is very popular with athletes, the use of PRP in tendinopathies is still scientifically discussed, particularly related to a disparity in the products called PRP. In order to optimize employment, it should be interested in the different stages of obtaining of the PRP. In this literature review, we analyzed in particular 8 parameters that can influence the quality of the PRP: (1) anticoagulants used to preserve the best feature of platelet; (2) centrifuge speeds used in order to extract platelets; (3) platelet concentrations and the presence of leukocytes and erythrocytes in the PRP; (4) the platelet activators for the mast of platelets and thus the release of growth factors; (5) use of local anesthetics to achieve infiltration, in addition to these parameters, it might be interesting to analyze other variables like: (6) employment or not of buffer to neutralize the acidity caused by anticoagulants; (7) injection under US guidance or not; and (8) volume of PRP injected to determine their influence on the healing potential. 相似文献
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Pezhman Beshkar Ehteramolsadat Hosseini Mehran Ghasemzadeh 《Transfusion and apheresis science》2018,57(1):76-81
Background
Regardless of different sources, methods or devices which are applied for preparation of therapeutic platelets, these products are generally isolated from whole blood by the sedimentation techniques which are based on PRP or buffy coat (BC) separation. As a general fact, platelet preparation and storage are also associated with some deleterious changes that known as platelet storage lesion (PSL). Although these alternations in platelet functional activity are aggravated during storage, whether technical issues within preparation can affect integrin activation and platelet adhesion to fibrinogen were investigated in this study.Methods
PRP- and BC-platelet concentrates (PCs) were subjected to flowcytometry analysis to examine the expression of platelet activation marker, P-selectin as well as active confirmation of the GPIIb/IIIa (αIIbβ3) on day 0, 1, 3 and 5 post-storage. Platelet adhesion to fibrinogen matrix was evaluated by fluorescence microscopy. Glucose concentration and LDH activity were also measured by colorimetric methods.Results
The increasing P-selectin expression during storage was in a reverse correlation with PAC-1 binding (r?=??0.67; p?=?.001). PRP-PCs showed the higher level of P-selectin expression than BC-PCs, whereas the levels of PAC-1 binding and platelet adhesion to fibrinogen matrix were significantly lower in PRP-PCs. Higher levels of active confirmation of the GPIIb/IIIa in BC-PCs were also associated with greater concentration of glucose in these products.Conclusion
We demonstrated the superior capacities of integrin activation and adhesion to fibrinogen for BC-PCs compared to those of PRP-PCs. These findings may provide more advantages for BC method of platelet preparation. 相似文献8.
D. J. Murray S. Javed N. Jain S. Kemp A. C. Watts 《Journal of hand and microsurgery》2015,7(2):320-325
Lateral epicondylosis is common, with various treatment modalities. Platelet—rich—plasma injections from autologous blood have recently been used in centres worldwide for the treatment of tennis elbow. We review and present the recent published evidence on the effectiveness of PRP injections for lateral epicondylosis. Nine studies met our inclusion criteria including 6 RCT’s for the purpose of analysis. PRP injections have an important and effective role in the treatment of this debilitating pathology, in cases where physiotherapy has been unsuccessful. 相似文献
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Namineni Kiran Kumar Mahaboob Shaik Koteswara Rao Nadella Balakrishna Manohar Chintapalli 《Journal of maxillofacial and oral surgery》2015,14(2):417-422