全文获取类型
收费全文 | 31962篇 |
免费 | 2333篇 |
国内免费 | 658篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 731篇 |
妇产科学 | 82篇 |
基础医学 | 1333篇 |
口腔科学 | 47篇 |
临床医学 | 6006篇 |
内科学 | 14168篇 |
皮肤病学 | 34篇 |
神经病学 | 560篇 |
特种医学 | 1301篇 |
外科学 | 2820篇 |
综合类 | 4077篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 577篇 |
眼科学 | 26篇 |
药学 | 1982篇 |
12篇 | |
中国医学 | 868篇 |
肿瘤学 | 311篇 |
出版年
2024年 | 62篇 |
2023年 | 617篇 |
2022年 | 997篇 |
2021年 | 1401篇 |
2020年 | 1316篇 |
2019年 | 1481篇 |
2018年 | 1358篇 |
2017年 | 876篇 |
2016年 | 768篇 |
2015年 | 953篇 |
2014年 | 2147篇 |
2013年 | 1877篇 |
2012年 | 1398篇 |
2011年 | 1640篇 |
2010年 | 1381篇 |
2009年 | 1330篇 |
2008年 | 1498篇 |
2007年 | 1514篇 |
2006年 | 1262篇 |
2005年 | 1195篇 |
2004年 | 953篇 |
2003年 | 884篇 |
2002年 | 741篇 |
2001年 | 757篇 |
2000年 | 619篇 |
1999年 | 613篇 |
1998年 | 558篇 |
1997年 | 571篇 |
1996年 | 448篇 |
1995年 | 410篇 |
1994年 | 390篇 |
1993年 | 320篇 |
1992年 | 333篇 |
1991年 | 297篇 |
1990年 | 260篇 |
1989年 | 193篇 |
1988年 | 205篇 |
1987年 | 199篇 |
1986年 | 177篇 |
1985年 | 166篇 |
1984年 | 171篇 |
1983年 | 129篇 |
1982年 | 121篇 |
1981年 | 87篇 |
1980年 | 66篇 |
1979年 | 60篇 |
1978年 | 41篇 |
1977年 | 28篇 |
1976年 | 24篇 |
1973年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
AClinicalStudyofReversingLeftVentricularHypertrophyinHypertensivePatientsbyAdalatZhangFumin(张馥敏)XuDi(许迪)YongYonghong(雍永宏)Chen... 相似文献
2.
目的探讨左半结肠癌急性梗阻Ⅰ期切除吻合的Ⅰ临床应用价值。方法对1988年1月至2006年12月24侧实施左半结肠癌急性梗阻Ⅰ期切除吻合手术患者的资料进行回顾性总结。结果24例均未发生吻合口漏,仅3例发生切口感染,经局部换药处理Ⅱ期愈合。结论积极的术前准备、术中彻底的肠减压能为左半结肠癌急性梗阻Ⅰ期切除吻合提供安全保证. 相似文献
3.
R. J. Bosma A. J. Kwakernaak J. J. Homan van der Heide P. E. de Jong G. J. Navis 《American journal of transplantation》2007,7(3):645-652
Obesity is a risk factor for renal graft loss. Higher body mass index (BMI) in native kidneys is associated with glomerular hyperfiltration. Whether higher BMI in renal transplants is associated with hyperfiltration is unknown. We investigated the impact of BMI on renal hemodynamics 1 year post-transplant. We analyzed glomerular filtration rate (GFR, (125)I-iothalamate) and effective renal plasma flow (ERPF, (131)I-hippurate) in 838 kidney transplants. Data were analyzed for all patients and for the subpopulation without diabetes. Long-term impact of BMI and renal hemodynamics were explored by Cox-regression. With higher BMI GFR and filtration fraction (FF) increased significantly. Multivariate analysis supported impact of BMI on GFR (adjusted r(2) of the model 0.275) and FF (adjusted r(2) of the model 0.158). This association was not explained by diabetes mellitus. On Cox-regression analysis, lower GFR and higher FF were independent determinants of overall graft loss and graft loss by patient mortality. Lower GFR and higher BMI were determinants of death-censored graft loss, with borderline contribution of higher FF. In renal transplants higher BMI is independently associated with higher GFR and FF one year posttransplant, suggesting glomerular hyperfiltration with altered afferent-efferent balance. Mechanisms underlying the long-term prognostic impact of hyperfiltration deserve further exploration. 相似文献
4.
Terry Joe Sprinkle Julia F. Agee Russell B. Tippins C. Richard Chamberlain Guy B. Faguet George H. DeVries 《Brain research》1987,426(2):349-357
Monoclonal antibodies against human and bovine 2′:3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) were generated by fusing FOX-NY myeloma cells with spleen cells from RBF/Dn mice previously immunized with the purified brain antigens. The enzyme isolated from bovine brain was quite basic, with an isoelectric point of 9.71 and both the bovine and human enzymes consisted of a closely spaced doublet at approximately 44 and 46 kDa on SDS-PAGE. Six monoclonals were identified as strongly recognizing the enzyme on both ELISA plates and on immunoblots of whole brain protein. Four monoclonals very weakly cross-reacted with guinea pig myelin basic protein. In contrast with two previous reports, some of our monoclonal antibodies did immunostain 2 or 3 protein bands in peripheral nerve, two bands closely corresponding to those immunostained in central nervous system (CNS) myelin, the Wolfgram protein fraction and in acetone powders of whole brain. Each of the 6 monoclonals reacting strongly on immunoblots recognized the enzyme in from 2 to 5 of the species examined (human, bovine, rat, mouse and rabbit). In addition, all 6 monoclonals that immunostained the enzyme in whole brain, myelin and Wolfgram protein immunoblots recognized both CNP1 (44 kDa) and CNP2 (46 kDa). The two closely spaced protein bands observed on SDS-PAGE and previously stained on immunoblots of CNS CNPase using polyvalent rabbit anti-bovine CNPase antisera, and now different monoclonal antibodies, appear to be immunologically related and to contain highly conserved sequences. 相似文献
5.
Takayuki Murakami Atsushi Komiya Kunihisa Mikata Shigeki Kaneko Ichiro Ikeda 《International journal of urology》2007,14(3):240-241
Abstract: A 66-year-old man was referred to our hospital with chest discomfort and shortness of breath. Seven months previously he had undergone a laparoscopic left nephroureterectomy for a left renal pelvic tumor and was given two cycles of adjuvant chemotherapy (methotrexate, epirubicin and cisplatin). Echocardiogram showed an 8-mm sized mass extending from the right atrium into the right ventricle. On computed tomography, multiple lung tumors, as well as the right atrial and ventricular mass, were seen. The patient died of acute heart failure caused by right ventricular outflow obstruction. On autopsy, a right atrial and ventricular metastasis of the initial transitional cell carcinoma was found. The patient's cause of death was acute heart failure as a result of cardiac metastasis of his initial renal pelvic carcinoma. 相似文献
6.
Brigden Geoffrey Zanelli Giussepe Lahiri Avijit Raftery Edward 《European journal of nuclear medicine and molecular imaging》1990,16(11):795-799
A new, single bolus method of in vivo blood pool imaging using a technetium Tc99m phosphine isocyanide complex (DEPIC) which binds to pre-albumin was evaluated in volunteers (n=4) and patients (n=20). DEPIC was assessed for its safety and possible drug interactions. Its duration of action and quality of ventriculography were compared with imaging using standard in vivo red cell labelling (PYP) during two 3-h scanning periods 1 week apart. DEPIC had a mean plasma halflife of 3.3 h. The count rate over the left ventricle was initially 42% higher with DEPIC than with PYP. However, removal of DEPIC by the liver resulted in equivalent count rates by 1 h, and by 3 h PYP count rates were 22% higher than DEPIC. Immediately post injection mean (SD) difference in the left ventricular ejection fraction between the two methods was 2.4% (7.7%). Satisfactory DEPIC scans were obtained up to 2 h post injection, but by 3 h there was a mean difference of 13% (11.3%). DEPIC was found to be a safe alternative to red all labelling for blood pool angiography, suitable for routine work. The single bolus methodology and high initial count rates offer improved efficiency and a capability for truly emergency scanning. 相似文献
7.
我院治疗66例心间隔缺损的病例中,有4例合并哑性动脉导管未闭(简称PDA),发生率6%。全组病例术前均无PDA临床体征,1例术前再次复查心脏彩超时发现,其余3例均漏诊。1例先处理PDA,3例在纠正心内畸形同时处理PDA。心间隔缺损合并哑性PDA容易漏诊,但有其临床特点,手术可先处理PDA,或在体外循环下处理PDA。 相似文献
8.
非瓣膜病房颤患者左心耳血流动力学的TEE研究 总被引:1,自引:0,他引:1
应用多平面经食管超声心动图技术(M-TEE),对30例健康人和30例非瓣病房颤患者(NVAF)心底短轴切面测量了左心耳最大直径,同一心动周期内左心耳最大及最小面积及左心耳最大空速度,产将NVAF患者按照自发显影及血栓的有无分为2组。发现NVAF组左心耳增大,收缩力及血流速度均减低,且这种变化在有血栓和有血栓形成倾向的患者中更为明显。 相似文献
9.
Sintov Amnon Scott William A. Gallagher Kim P. Levy Robert J. 《Pharmaceutical research》1990,7(1):28-33
Epicardial antiarrhythmic drug administration was studied as a therapeutic approach for experimental ventricular tachycardia (VT) in an open-chest dog model. Lidocaine-polyurethane matrices (28%, w/w) were formulated as a model system. Matrices were placed on the left ventricular epicardium in each of 23 anesthetized open-chest dogs with ouabain-induced VT, to evaluate effectiveness in restoring sinus rhythm. Conversion occurred in all animals treated with matrices containing 300 mg or more of lidocaine after 1.5 to 7.0 min. The matrix lidocaine content correlated linearly with the time required for conversion to sinus rhythm (r = 0.75, P = 0.0002); irrespective of matrix size the myocardial/plasma lidocaine ratio was 20.1 ± 4.2 (mean ± SD) at the time of conversion. In a separate series of five dogs without ventricular tachycardia, systolic wall thickening measured with sonomicrometers after 5 min of controlled-release lidocaine administration (500- to 1000-mg matrix lidocaine content, 7.48 ± 3.49-mg/kg dose) was only minimally diminished (–14.1%) and this effect was observed only at the site of matrix placement on the anterior-apical epicardium. In contrast, intracoronary injection of 0.3 or 1.0 mg/kg of lidocaine-HCl resulted in complete elimination of wall thickening or replacement by systolic thinning. Thus epicardial administration of lidocaine from polyurethane matrices was an effective means of treating ouabain-induced ventricular tachycardia. Regional myocardial function in the vicinity of the matrices was modified to a very limited degree, supporting the view that the matrices can be used safely, without serious risk to ventricular contractile performance. 相似文献
10.
通过42例重型肺心病、7例轻型肺心病、16例肺心病伴发冠心病患者和30例正常人在静息状态下的左右心脏射血分数及其临床资料的分析表明,重型肺心病患者在病情的急性发作期,存在有不同程度的左心功能不全,而轻型肺心病患者则无左心功能不全的表现。表明慢性肺心病仅在病程晚期,才由以右心为主的疾病发展成为全心病。本文还对重型肺心病与肺心病伴发冠心病患者的左心功能进行比较,结果表明,肺心病伴发冠心病患者左室功能受损程度更为明显,双重病因导致的左室功能减退,常造成心肌更严重的损害而且不容易恢复。 相似文献