全文获取类型
收费全文 | 309324篇 |
免费 | 28017篇 |
国内免费 | 10392篇 |
专业分类
耳鼻咽喉 | 3996篇 |
儿科学 | 4958篇 |
妇产科学 | 4904篇 |
基础医学 | 44585篇 |
口腔科学 | 10374篇 |
临床医学 | 25734篇 |
内科学 | 33702篇 |
皮肤病学 | 4303篇 |
神经病学 | 17940篇 |
特种医学 | 7592篇 |
外国民族医学 | 34篇 |
外科学 | 28576篇 |
综合类 | 48399篇 |
现状与发展 | 27篇 |
一般理论 | 26篇 |
预防医学 | 31085篇 |
眼科学 | 4752篇 |
药学 | 30159篇 |
353篇 | |
中国医学 | 28870篇 |
肿瘤学 | 17364篇 |
出版年
2024年 | 1086篇 |
2023年 | 5303篇 |
2022年 | 9963篇 |
2021年 | 13352篇 |
2020年 | 13022篇 |
2019年 | 13871篇 |
2018年 | 12734篇 |
2017年 | 11792篇 |
2016年 | 11400篇 |
2015年 | 11332篇 |
2014年 | 20370篇 |
2013年 | 22093篇 |
2012年 | 18683篇 |
2011年 | 20562篇 |
2010年 | 16622篇 |
2009年 | 14911篇 |
2008年 | 14552篇 |
2007年 | 14566篇 |
2006年 | 12780篇 |
2005年 | 10894篇 |
2004年 | 9109篇 |
2003年 | 7792篇 |
2002年 | 5975篇 |
2001年 | 5019篇 |
2000年 | 4404篇 |
1999年 | 3690篇 |
1998年 | 3164篇 |
1997年 | 2898篇 |
1996年 | 2466篇 |
1995年 | 2462篇 |
1994年 | 2228篇 |
1993年 | 1977篇 |
1992年 | 1703篇 |
1991年 | 1583篇 |
1990年 | 1383篇 |
1989年 | 1350篇 |
1988年 | 1187篇 |
1987年 | 1085篇 |
1986年 | 976篇 |
1985年 | 2454篇 |
1984年 | 2648篇 |
1983年 | 1685篇 |
1982年 | 2216篇 |
1981年 | 1568篇 |
1980年 | 1335篇 |
1979年 | 1203篇 |
1978年 | 942篇 |
1977年 | 708篇 |
1976年 | 837篇 |
1975年 | 532篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
《Clinical Lymphoma, Myeloma & Leukemia》2020,20(8):e461-e467
IntroductionVon Willebrand factor (vWF) cleaving protease ADAMTS-13 has a key role for maintaining normal size of vWF. A deficiency or dysfunction of vWF cleaving protease is associated with ultra large vWF multimers and thrombotic microangiopathy. Patients with cancers have reduced levels of vWF cleaving protease. In this pilot study, we have evaluated whether or not deficiencies of ADAMTS-13 were present in myelodysplastic syndromes (MDS). Moreover, we assessed if a reduction in basal levels of ADAMTS-13 may play a role in the prognosis of MDS.Patients and MethodsWe measured and compared the levels of vWF cleaving protease ADAMTS-13 in 100 patients with MDS and 35 healthy controls. Patients were divided into 2 groups according to the International Prognostic Scoring System: group I consisting of 44 patients with low-risk MDS and group II of 56 patients with high-risk MDS. Patients with high-risk and low-risk MDS presented significantly lower levels of ADAMTS-13 than controls (P < .001 and P = .0177, respectively). High-risk patients had significantly lower levels of ADAMTS-13 when compared with the low-risk group (P < .001).ResultsWe found that reduced levels of ADAMTS-13 have a relationship with overall survival (P < .001). Statistical analysis showed that ADAMTS-13 correlates with cytogenetics (P < .001) and a tendency of slight correlation with platelet count and basal levels of ADAMTS-13 (R, 0.35; P value, 0.001). Moreover, we found that levels of ADAMTS-13 have correlation with response to treatment (P < .001).ConclusionsADAMTS-13 in MDS might represent a surrogate marker of prognosis, response to therapy, or disease progression. Further studies are needed. 相似文献
62.
目的:调查研究不同海拔高度官兵的亚健康状态。方法抽取4种海拔(1500、3700、5380、5390 m)的高原边防和后勤官兵共344名,进行康奈尔健康量表测评。测评结果建立数据库,用SPSS 17.0进行数据分析,测量相关数据的前后变化。结果数据结果显示不同海拔高度的官兵健康状况随海拔高度的变化存在差异,而高原边防和后勤官兵的整体健康状况差异不大。结论高原官兵要改善亚健康状态,应该从思想教育,心理调整和保障制度等多方面着手,切实保障官兵健康和提高部队战斗力。 相似文献
63.
Ling Zhang Xue-Jun Shang Hong-Fei Li Yu-Qin Shi Wei Li Maria E Teves Zhi-Qiong Wang Gao-Feng Jiang Shi-Zhen Song Zhi-Bing Zhang 《Asian journal of andrology》2015,17(1):86-93
Mammalian spermatogenesis is a well-organized process of cell development and differentiation. Meiosis expressed gene 1 (MEIG1) plays an essential role in the regulation of spermiogenesis. To explore potential mechanisms of MEIG1''s action, a yeast two-hybrid screen was conducted, and several potential binding partners were identified; one of them was membrane occupation and recognition nexus repeat containing 3 (MORN3). MORN3 mRNA is only abundant in mouse testis. In the testis, Morn3 mRNA is highly expressed in the spermiogenesis stage. Specific anti-MORN3 polyclonal antibody was generated against N-terminus of the full-length MORN3 protein, and MORN3 expression and localization was examined in vitro and in vivo. In transfected Chinese hamster ovary cells, the antibody specifically crossed-reacted the full-length MORN3 protein, and immunofluorescence staining revealed that MORN3 was localized throughout the cytoplasm. Among multiple mouse tissues, about 25 kDa protein, was identified only in the testis. The protein was highly expressed after day 20 of birth. Immunofluorescence staining on mixed testicular cells isolated from adult wild-type mice demonstrated that MORN3 was expressed in the acrosome in germ cells throughout spermiogenesis. The protein was also present in the manchette of elongating spermatids. The total MORN3 expression and acrosome localization were not changed in the Meig 1-deficient mice. However, its expression in manchette was dramatically reduced in the mutant mice. Our studies suggest that MORN3 is another regulator for spermatogenesis, probably together with MEIG1. 相似文献
64.
目的探讨嵌顿痔不同治疗方法的疗效。方法回顾性分析2009年8月至2012年8月迁西县人民医院确诊为嵌顿痔的160例患者的临床资料,其中采取外剥内扎法的80例患者作为A组,吻合器痔上黏膜环切术(PPH)结合外痔血栓剥除术的80例患者作为B组。对比分析两组患者的手术时间、住院时间、住院费用等指标及临床疗效,对比分析两组术后6个月并发症发生情况。结果B组患者的手术时间、住院时间显著少于A组[(15.4±1.1)min比(38.7±0.5)min,(5.3±0.6)d比(12.4±1.3)d,P<0.01];B组患者的有效率显著高于A组(88.8%比66.3%),而总体并发症发生率及复发率显著低于A组(17.5%比33.8%,5%比18.8%,P<0.05)。结论 PPH结合外痔血栓剥除术临床疗效显著。 相似文献
65.
66.
The main of this study was to evaluate the mutagenic and carcinogenic potential of (+) – usnic acid (UA), using Somatic Mutation and Recombination Test (SMART) and the test for detecting epithelial tumor clones (wts) in Drosophila melanogaster. Larvae from 72 ± 4 h from Drosophila were fed with UA (5.0, 10.0 or 20.0 mM); urethane (10.0 mM) (positive control); and solvent (Milli-Q water, 1% Tween-80 and 3% ethanol) (negative control). ST cross produced increase in total mutant spots in the individuals treated with 5.0, 10.0 or 20.0 mM of UA. HB cross produced spot frequencies in the concentration of 5.0 mM that were higher than the frequency for the same concentration in the ST cross. In the highest concentrations the result was negative, which means that the difference observed can be attributed, in part, to the high levels of P450, suggesting that increasing the metabolic capacity maximized the toxic effect of these doses. In the evaluation of carcinogenesis using the wts test, the results obtained for the same concentrations of UA show a positive result for the presence of tumors when compared to the negative control. We conclude that UA has recombinogenic, mutagenic and carcinogenic effects on somatic cells in D. melanogaster. 相似文献
67.
A. Guerrero Gómez N. González Jaramillo J.A. Castro Pérez 《Revista espa?ola de anestesiología y reanimación》2019,66(1):10-17
Introduction
The fast track / ultra-fast-track protocols are techniques used to optimise the patient care process and a quick recovery after cardiac surgery. They are one of the mainstays of efficient practice. With their use, the length of hospital and intensive care unit (ICU) stays are reduced, with a direct impact on costs and the quality of the health service.Objective
To compare the length of stay in the ICU, length of hospital stay, and post-operative mortality in ultra-fast-track extubated (uFTE) patients and those with conventional extubation (CE) after cardiac surgery.Methods
Longitudinal, analytical, retrospective study was conducted, with the period between the time of surgery and discharge being included as the study period.Results
A total of 396 patients older than 18 years who required cardiac surgery were included, of whom 207 patients had (uFTE) and 189 had CE. Although the groups were not comparable due to the statistical differences found, when performing the multivariate adjustment, uFTE maintained its statistical independence and was associated with lower cardiovascular morbidity, such as myocardial ischaemia (95% CI: 0.37-0.86; P = .01) and lower post-surgical vasopressor requirement (95% CI: 0.18-0.49; P < .01). No significant differences were found in the length of hospital stay, ICU stay, or post-operative mortality in the ICU.Conclusion
Implementing the uFTE strategy, decreases cardiovascular morbidity and vasopressor requirement. The change to uFTE should be accompanied by changes in models and practices in patient recovery to standardised protocols. This study shows that uFTE did not reduce the length of ICU stay, hospital stay, or mortality. 相似文献68.
69.
Fabian M. Laage Gaupp Nadia Solomon Ivan Rukundo Azza A. Naif Erick M. Mbuguje Anish Gonchigar Minzhi Xing John D. Prologo Douglas D. Silin Frank J. Minja 《Journal of vascular and interventional radiology : JVIR》2019,30(12):2036-2040
Despite a population of nearly 60 million, there is currently not a single interventional radiologist in Tanzania. Based on an Interventional Radiology (IR) Readiness Assessment, the key obstacles to establishing IR in Tanzania are the lack of training opportunities and limited availability of disposable equipment. An IR training program was designed and initiated, which relies on US-based volunteer teams of IR physicians, nurses, and technologists to locally train radiology residents, nurses, and technologists. Preliminary results support this strategy for addressing the lack of training opportunities and provide a model for introducing IR to other resource-limited settings. 相似文献
70.
吴洁 《南京中医药大学学报》2019,35(4):376-378
回顾《内经》相关理论,指出痈脓病机关键在于气血凝滞、经络阻塞、脏腑失和,可分期论治。总结《金匮要略》治疗痈脓的方法,认为痈脓应尽早治疗,防邪深入;并根据证情辨证使用清热解毒,活血消散;排除脓毒,泄浊于外等治法。对现代临床仍具实用价值。 相似文献