Chromosome 1q terminal deletion resulting fromde novo translocation with an acrocentric chromosome

Summary Distal deletion of chromosome 1q has been reported in nearly 30 patients, all being associated with a deletion ranging from the 1q42 or q43 band to 1qter region. Here, we describe a girl with 1q terminal deletion resulting from an unbalancedde novo translocation t(1;D or G)(q44; p11), as revealed by the presence of a satellited feature and an NOR-stained region at the tip of 1q. We suggest that most of the phenotypic abnormalities seen in patients with 1q distal deletion are attributable to the monosomy for band 1q44.     

The kinetics and distribution of C9 and SC5b-9 in vivo: effects of complement activation.

Many diseases associated with complement activation are characterized by tissue deposition of components of the terminal complement complex (TCC). The ninth component of complement (C9) plays an important role in the cytolytic effects, and may contribute to the non-lethal cell-regulating functions of the TCC. In this study we examined the behaviour of radiolabelled human C9 and its soluble complexed form SC5b-9 in vivo in order to determine the effects of complement activation on its turnover, distribution and molecular size. In normal rabbits the metabolic parameters of 125I-C9 (median and range) were: plasma half-life (t1/2) 25.9 (20.6-29.5) h, fractional catabolic rate (FCR) 5.7 (5.3-7.0)%/h, and extravascular/intravascular ratio (EV/IV) 0.7 (0.6-1.1). The distribution of radiolabelled C9 amongst body tissues was similar to that observed for rabbit serum albumin (RSA). Activation of the complement cascade with i.v. injection of cobra venom factor (CVF) resulted in rapid disappearance of C9 from the plasma and accumulation of protein-bound radiolabeled in the spleen (exceeding the plasma concentration) and the liver. RSA metabolism and distribution were unaffected by CVF. Fine performance liquid chromatography (FPLC) gel filtration of plasma samples suggested that monomeric C9 was the only major radiolabelled protein present during normal turnovers, whereas CVF administration was accompanied by the prompt appearance of a high mol. wt species consistent in size with SC5b-9. When injected directly, 125I-SC5b-9 disappeared rapidly from the plasma, falling by 50% in 0.7 (0.6-0.8) h, and less than 15% remaining after 4 h with accumulation of protein-bound label in the spleen and liver. These results demonstrate the complexity of C9 metabolism during complement activation.     

ONSET AND TERMINAL ORIENTING RESPONSES AS A FUNCTION OF TASK DEMANDS

The frequency of response and trials to habituation of the electrodermal onset and terminal orienting response were manipulated as a function of discrimination tasks involving either stimulus content (pitch) or duration. There were no significant differences between the groups on either measure for onset ORs; however, the duration task group demonstrated more TORs and required a greater number of trials to habituate than the content task group. The results, interpreted in terms of the development of cortical models, supported Stern's suggestion that OR and TOR habituation are related to the content and duration of the stimulus respectively.     

晚期妊娠合并子宫肌瘤治疗的探讨

目的　探讨晚期妊娠合并子宫肌瘤的最佳临床处理方法。方法　对 6 7例晚期妊娠合并子宫肌瘤病例的治疗进行回顾性分析。结果　 6 7例妊娠合并子宫肌瘤患者中 ,单发肌瘤4 2例 ,多发肌瘤 2 5例 ;其中经阴道分娩 12例 ;剖宫产 5 5例 ;剖宫产加肌瘤剔除术 4 0例 ,剖宫产加子宫次全切除术 3例。结论　妊娠合并子宫肌瘤患者剖宫产率高 ,大部分病例可在剖宫产同时行肌瘤剔除术。     

Palliative care in patients with cancer of the head and neck

Palliative care is the active total care of patients whose disease is not responsive to curative treatment. Patients with end-stage head and neck cancer have particular problems because of the impact of the tumour on the airway, the upper gastrointestinal tract and the major senses. Patients referred for palliative care were identified from the hospice database and the nature, incidence and management of their problems, and the role of the hospice in their care, was reviewed from in-patient and home care notes and patient-generated problem lists. Thirty-two male and six female patients with a median age of 64 years were identified. Locoregional recurrence was present in 79% of patients. Pain, weight loss, feeding difficulties, dysphagia, respiratory symptoms, xerostomia, oral thrush and communication difficulties were the major problems. The management of each, and of the terminal events encountered in the group, is discussed.     

我对SCSI的认识

简要地描述了SCSI的性能、用途以及使用的注意事项     

Assessing accurate sizes of synaptic vesicles in nerve terminals

Chemical synaptic transmission occurs when vesicles within a presynaptic neuron fuse to the membrane and release their neurotransmitter content into the synaptic cleft, eliciting a response in the postsynaptic cell. If concentration of neurotransmitter is the same in all synaptic vesicles, the volume of the vesicle determines how much transmitter is released. Thus, variation in vesicular volume may contribute to observed variance of synaptic quantal unit size. The present study provides an approach to more fully and accurately characterize the dimensions of synaptic vesicles within a population containing varied sizes of vesicles. The methodology can be applied in a wide range of stereological problems. The approach characterizes the distribution of vesicle sizes within a population and provides a means to assess effects of experimental manipulations on vesicle dimensions. The mathematical treatments to obtain the true distribution of vesicle sizes involve extraction of the observed distribution from an enlarged population containing smaller vesicle diameters produced by sectioning of the specimens. A FORTRAN program is provided.     

心脏不停跳心内直视术后护理体会

目的:探讨浅低温体外循环心脏不停跳心内直视手术(简称不停跳术)后的护理体会。方法:对32例不停跳术和30例阻断升主动脉中低温体外循环心内直视术(简称停跳术),在术后的相关并发症和血管活性药物等护理方面进行比较分析。结果:停跳术在肺部并发症、血管活性药物、ICU入住时间均优于不停跳术,在血红蛋白尿并发症方面有待于提高和改进。结论:不停跳术由于术中对心肌保护更加充分,术后心功能恢复较快,呼吸道并发症、血管活性药物用药均明显减少,ICU入住时间、住院日数缩短,减轻了病人的经济负担,术后随访3~12个月均恢复良好。     

急性心肌梗死并左心衰竭与V_1导联P波终末电势变化

<正> 目前,急性心肌梗死(AMI)因心律失常致死的数量已减少,而在AMI的死亡原因中,心力衰竭变得更加突出。所以,AMI并发心力衰竭的正确诊断和有效治疗已成为降低AMI死亡率的关键问题。1 资料与方法1.1 资料 收集本科1988年1月至2002年12月根据临床症状,心电图和心肌酶学的变化明确诊断AMI抢救成功的并发症左心衰竭的62例患者的相关资料,其中男51例,女11例,年龄28～79岁,平均年龄55.6岁。前壁(包括前间壁、前壁、广泛前壁)38例,下壁10例,下壁+正后壁7例,前壁+下壁4例,非Q波型3例,所有患者均为首次发病。1.2 方法 所有患者在CCU病房中除了接受AMI常规治疗     

基于Android智能终端的医院移动护理系统应用效果评价

借助条码、专用腕带、无线局域网,依托医院信息系统和电子病历系统,开发出基于Android智能终端的移动护理系统并应用于临床。将医院信息系统向病房扩展和延伸,实现了护士的床边操作,优化了护理工作流程,提高了工作效率,保障了工作质量,提升了护理管理水平和病人满意度。