不同方法修复儿童足跟轮辐伤皮肤缺损伴跟腱外露

目的 探讨不同方法 修复儿童足跟轮辐伤皮肤缺损伴跟腱外露的临床效果.方法 采用腓肠神经营养血管皮瓣、足跟外侧动脉皮瓣和邻位局部内侧或外侧旋转皮瓣3种皮瓣以及人工真皮覆盖修复22例儿童足跟部轮辐伤皮肤缺损伴跟腱外露创面.观察创面愈合情况.结果 患儿均获得随访,时间3～10个月.2例腓肠神经营养血管皮瓣远端皮缘发生血运障碍...     

羟苯磺酸钙治疗糖尿病性皮肤溃疡的临床研究

[目的]评价羟苯磺酸钙治疗糖尿病性皮肤溃疡的疗效和安全性.[方法]采用双盲临床随机对照试验.76例糖尿病性皮肤溃疡患者,随机分为试验组和对照组.试验组38例服用羟苯磺酸钙;对照组38例服用安慰剂维生素C;疗程8周.[结果]试验组溃疡愈合的速度与程度均明显优于对照组.总有效率试验组为94.74%,对照组为52.63%,两者之间有显著差异(P＜0.01).服药期间肝肾功能无异常改变.[结论]羟苯磺酸钙是治疗糖尿病性皮肤溃疡有效安全的药物.     

Does Probiotic Consumption Enhance Wound Healing? A Systematic Review

The use of probiotics is one of the emerging lines of treatment for wound healing. This systematic review aimed to summarize currently available evidence on the effect of oral or enteral probiotic therapy on skin or oral mucosal wound healing in humans. To verify the developments in this field and the level of available scientific evidence, we applied a broad search strategy with no restrictions on wound type, target population, probiotic strain, or intervention protocol used. This review included seven studies involving 348 individuals. Four studies reported positive outcomes for healing improvement after probiotic therapy, and none of the studies reported adverse effects or a marked increase in wound healing time. The positive or neutral results observed do not generate strong evidence regarding the effectiveness of probiotics for wound healing. However, they suggest a promising field for future clinical research where the probiotic strains used, type of wounds, and target population are controlled for.     

Nutritional Therapy in Persons Suffering from Psoriasis

Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play a part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities in persons with psoriasis. A change of eating habits can improve the quality of life of patients by relieving skin lesions and by reducing the risk of other diseases. A low-energy diet is recommended for patients with excess body weight. Persons suffering from psoriasis should limit the intake of saturated fatty acids and replace them with polyunsaturated fatty acids from the omega-3 family, which have an anti-inflammatory effect. In diet therapy for persons with psoriasis, the introduction of antioxidants such as vitamin A, vitamin C, vitamin E, carotenoids, flavonoids, and selenium is extremely important. Vitamin D supplementation is also recommended. Some authors suggest that alternative diets have a positive effect on the course of psoriasis. These diets include: a gluten-free diet, a vegetarian diet, and a Mediterranean diet. Diet therapy for patients with psoriasis should also be tailored to pharmacological treatment. For instance, folic acid supplementation is introduced in persons taking methotrexate. The purpose of this paper is to discuss in detail the nutritional recommendations for persons with psoriasis.     

Preliminary Characterization of a Polycaprolactone-SurgihoneyRO Electrospun Mesh for Skin Tissue Engineering

Skin is a hierarchical and multi-cellular organ exposed to the external environment with a key protective and regulatory role. Wounds caused by disease and trauma can lead to a loss of function, which can be debilitating and even cause death. Accelerating the natural skin healing process and minimizing the risk of infection is a clinical challenge. Electrospinning is a key technology in the development of wound dressings and skin substitutes as it enables extracellular matrix-mimicking fibrous structures and delivery of bioactive materials. Honey is a promising biomaterial for use in skin tissue engineering applications and has antimicrobial properties and potential tissue regenerative properties. This preliminary study investigates a solution electrospun composite nanofibrous mesh based on polycaprolactone and a medical grade honey, SurgihoneyRO. The processing conditions were optimized and assessed by scanning electron microscopy to fabricate meshes with uniform fiber diameters and minimal presence of beads. The chemistry of the composite meshes was examined using Fourier transform infrared spectroscopy and X-ray photon spectroscopy showing incorporation of honey into the polymer matrix. Meshes incorporating honey had lower mechanical properties due to lower polymer content but were more hydrophilic, resulting in an increase in swelling and an accelerated degradation profile. The biocompatibility of the meshes was assessed using human dermal fibroblasts and adipose-derived stem cells, which showed comparable or higher cell metabolic activity and viability for SurgihoneyRO-containing meshes compared to polycaprolactone only meshes. The meshes showed no antibacterial properties in a disk diffusion test due to a lack of hydrogen peroxide production and release. The developed polycaprolactone-honey nanofibrous meshes have potential for use in skin applications.     

创伤性胫前皮肤缺损骨不连医源性因素分析及防治

目的探讨外伤性胫前皮肤缺损骨不连医源性因素、治疗方法及预防措施.方法对136例外伤性胫前皮肤缺损,进行回顾性研究,分析医源性因素,提出预防措施,随访治疗效果.采用7种局部转移皮瓣和6种游离皮瓣移植治疗皮肤缺损,骨不连、骨缺损均采用带血管的骨移植.结果136例中121例得到6～28个月随访,平均17个月.局部皮瓣转移全部成活,游离皮瓣移植中7例术后发生血管危象,经探查4例成活,3例失败,二期以带胫后血管的对侧小腿内侧皮瓣为受区血管蒂的皮瓣移植修复治愈.骨不连、骨缺损行骨移植后均在术后3个月愈合,骨髓炎治愈.结论医源性技术缺陷是外伤性胫前皮肤缺损骨不连的重要因素,针对各种不同的因素进行预防、合理治疗可获得满意效果.     

Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates,Paris, France

We describe 7 cases of extensive tinea corporis since 2018 in a hospital in Paris, France, after failure to cure with terbinafine. Molecular analysis indicated Trichophyton mentagrophytes internal transcribed spacer type VIII (T. indotineae). This strain, which has mutations in the squalene epoxidase gene, is spreading on the Indian subcontinent.     

Neuroimaging findings of linear scleroderma of the head and face: a case report

Linear scleroderma of the head and face is a rare connective tissue disorder characterized by linear depressed scarring in the frontoparietal area of the face. Here, we report a patient with linear scleroderma of the head and face with neurological symptoms such as spontaneous epilepsy and numbness of the right limb as well as the presence of white matter lesions. The patient underwent computed tomography and 3.0-T magnetic resonance examinations including diffusion weighted imaging, diffusion tensor imaging, and perfusion imaging. The imaging findings suggested a disrupted fiber tract and decreased relative cerebral blood flow. Our observation may help to improve the diagnosis and treatment of linear scleroderma of the head and face.     

颞浅动脉头皮岛状皮瓣修复眉缺损20例体会

【目的】通过对不同原因造成的眉部缺损采用颞浅动脉头皮岛状皮瓣修复,探索颞浅动脉头皮岛状皮瓣修复眉缺损的优越性。【方法】对患者进行相宜的眉型设计和皮瓣设计,切取皮瓣修复缺损眉区创面。【结果】本组共20例28侧皮瓣全部存活,伤口一级愈合,未发现皮瓣坏死及伤口感染。【结论】颞浅动脉头皮岛状皮瓣是修复眉缺损的一种较好的方法,有着更广阔的应用前景。