重症溃疡性结肠炎临床和病理分析

目的:对重症溃疡性结肠炎进行临床和病理分析并讨论其临床意义。方法:重症溃疡性结肠炎(UC)患者119例。采取肠外静脉补充足够的营养,完全胃肠道休息,治疗4周后进行结肠镜检查。结果:重症UC经过4周治疗后临床痊愈36例(39.3%),好转65例(54.6%),无效18例(15.1%),总有效率84.9%。初发型,复发型和持续型UC内镜下和组织学存在一定差异,但治疗总有效率明显差异。结论:初发型,复发型和持续型UC内镜下和组织学存在一定差异,肠外静脉高营养疗法是一种有效可行的方法。     

高脂、酗酒引发重症胰腺炎治疗探讨

[目的]探讨高脂、酗酒引发重症胰腺炎的治疗。[方法]回顾性分析非手术治疗20例，手术治疗7例，EST治疗4例的临床资料。[结果]非手术治疗组除1例死于心肌梗塞、其余19例存活。EST治疗4例均存活。早期手术治疗7例中4例术后死于多脏器衰竭、中毒性休克、真菌感染、其余3例存活。[结论]高脂、酗酒引发重症胰腺炎行非手术和EST治疗效果显著。     

非常复杂型视网膜脱离的治疗探讨

目的:探讨治疗非常复杂型视网膜脱离的方法。方法:31例(31眼)非常复杂型视网膜脱离,包括原发性裂孔性视网膜脱离伴PVR-D3级及前段玻璃体严重增殖者14只眼;巨大裂孔性视网膜脱离伴严重PVR 8只眼;严重眼外伤伴眼内容物脱出及严重PVR 9只眼。采用巩膜冷凝、环扎、硅胶填压、玻璃体切割、视网膜前膜剥离/切除,视网膜松解性切开,过氟化碳液体注入,眼内/眼外排液以及硅油眼内填充等方法治疗。结果:随访3～16个月,31眼中,21只眼视网膜完全复位,占67.7％;5只眼大部分复位,占16.1％;5只眼未能复位,占16.1％。术后视力,除了失败的5只眼外,在其余的26只眼中,有一眼视力较术前下降,其余25只眼的视力均有不同程度的提高。结论:PVR及巨大裂孔性视网膜脱离的效果较好,分别有71.4％及87.5％完全复位,严重外伤的治疗效果较差。眼科学报1998;14:90—93。     

慢性重型乙型肝炎患者隐孢子虫感染的研究

目的探讨慢性重型肝炎与隐孢子虫感染的关系，为防治该病提供依据。方法用金胺-酚染色法(AA—P)和改良抗酸染色法(MAF)检测218例慢性重型乙型肝炎(慢重肝)患者和140例腹泻儿童粪便标本隐孢子虫卵囊，用PCR技术检测其DNA，并进行内切酶分析；对隐孢子虫感染影响因素进行分析。结果经AA-p、MAF和PCR检测，慢重肝患者隐孢子虫感染率分别为4．1％、3．2％和6．0％；腹泻儿童感染率为0．7％、0．7％和1．4％、PCR结果显示，慢重肝患者隐孢子虫感染率高于腹泻儿童；阳性患者腹泻史、动物接触史明显高于阴性患者，农村患者感染率高于城市患者结论慢性重型肝炎患者对隐孢子虫的易感性增加，隐孢子虫感染是引起慢性重型肝炎患者腹泻和可能加重其病情的因素之一。     

益气养血补肾法合康力龙治疗重型再生障碍性贫血的临床研究

目的观察益气养血补肾法治疗重型再生障碍性贫血的临床疗效.方法用益气养血补肾法合康力龙治疗重型再生障碍性贫血33例,观察治疗后患者临床表现、血常规等指标的变化.结果治疗后证候学积分较疗前有显著性下降(P<0.01),在改善症状方面有效率为90.91%,临床疗效总有效率88.24%,患者的血色素从疗后第6个月开始较疗前升高(P<0.01),白细胞计数比疗前升高(P＜0.05),疗后网织红细胞计数较疗前有显著性升高(P<0.01).结论益气养血补肾法合康力龙对重型再生障碍性贫血患者有较好的临床疗效.     

Effects of Enteral Immunonutrition on the Maintenance of Gut Barrier Function and Immune Function in Pigs With Severe Acute Pancreatitis

Background: This study evaluated the effects of enteral immunonutrition (EIN) supplemented with glutamine, arginine, and probiotics on gut barrier function and immune function in pigs with severe acute pancreatitis (SAP). Methods: The model was induced by retrograde injection of 5% sodium taurocholate and trypsin via the pancreatic duct. After induction of SAP, 18 pigs were randomly divided into 3 groups, in which either parenteral nutrition (PN), control enteral nutrition (CEN), or EIN was applied for 8 days. Serum and pancreatic fluid amylase concentration was determined. Intestinal permeability (lactulose to mannitol ratio) was measured by high‐performance liquid chromatography, and plasma endotoxin was quantified by the chromogenic limulus amebocyte lysate technique. Samples of venous blood and organs were cultured using standard techniques. Pancreatitis severity and villi of ileum were scored according to histopathologic grading. Plasma T‐lymphocyte subsets were measured by flow cytometry, and immunoglobulins (Igs) were determined via enzyme‐linked immunosorbent assay. Results: There were no significant differences in serum and pancreatic fluid amylases concentrations or in pancreatitis severity between any 2 of the 3 groups. Compared with PN and CEN, EIN significantly decreased intestinal permeability, plasma endotoxin concentration, and the incidence and magnitudes of bacterial translocation, but increased ileal mucosal thickness, villous height, crypt depth, and percentage of normal intestinal villi. Significant differences were found in CD3⁺, CD4⁺ lymphocyte subsets, the ratio of CD4⁺: CD8⁺ lymphocyte subsets, and serum IgA and IgG, but not IgM, between any 2 of the 3 groups. Conclusions: EIN maintained gut barrier function and immune function in pigs with SAP.     

Postural imbalance in non-treated adolescent idiopathic scoliosis at different periods of progression

The aim of this study was to test the hypothesis that imbalance in patients with a severe deformity of the spine is associated with an increase in the sensory integration disorder. This paper is a case comparison study. Patients were divided into three groups: able-bodied (n = 53), observation (n = 23), and pre-brace (n = 26) groups. Time domain parameters (sway area, position and displacement) and structural posturographic parameters [mean distance (MD) and mean peak (MP)] were calculated from the COP excursion using a force platform. A sensory integration disorder could be an important factor in the progression of the scoliotic curve. Significant differences were found in time domain between observation, pre-brace and able-bodied groups. The results for the structural posturographic parameters showed significant differences between the pre-brace and the able-bodied groups (P = 0.018 MD and P = 0.02 MP) demonstrating a perturbation in sensory integration system by an increase of imbalance. The absence of statistical difference between the observation and the pre-brace groups for the structural posturographic parameters indicates a perturbation of sensory integration system associated with curve progression. Our study has demonstrated that the pre-brace group is less stable than the able-bodied group. The severity of scoliosis in pre-brace scoliotic girls could be related to an increase in the sensory integration disorder.     

Introns 1 and 22 inversions and factor VIII inhibitors in patients with severe haemophilia A in southern Brazil

Summary.  A total of 107 unrelated severe haemophilia A patients living in the southern Brazilian state of Rio Grande do Sul were studied in relation to the prevalence of inversions present in introns 22 and 1 and a subsample of them (95) tested for the presence of Factor VIII inhibitors. These data were then incorporated with those from 15 other countries and 3871 patients. The frequencies of these two inversions show a remarkable homogeneity in series collected in different continents, from people with diverse ethnic extraction. The prevalence of inhibitors among patients with inversion 22, on the other hand, varies widely (5–51%; seven countries, 1482 patients), the value observed by us being the highest. The importance of obtaining data from patients throughout the world to clarify the aetiology of this important complicating factor in the therapeutics of the disease is emphasized.     

特发性脊柱侧凸不同固定术式疗效分析

目的 分析治疗特发性脊柱侧凸的不同手术方法和效果.方法 对1989年～2005年收治的34例特发性脊柱侧凸术前、术后临床资料进行分析,总结所采用不同术式的治疗效果.结果 34例分别采用了Harrington术式、联合Harrington-Luque(H-L)术式、Cotrel-Dubousset(C-D)双棍法及Texas Scottish-Rite Hospital(TSRH)三维矫正,平均矫正率分别为36.42%、45.18%、55.68%、63.28%,采用H-L、C-D和TSRH手术方法的矫正度均高于Harrington方法,其中以TSRH、C-D三维矫正系统效果最好.结论 手术矫正特发性脊柱侧凸效果是明显的,尤以近年运用的三维矫正系统效果更为优良.