Comparative effects of sevoflurane and propofol based general anaesthesia for elective surgery on memory

Introduction

Unconscious processing of words during general anaesthesia has been suggested. We used the process dissociation procedure (PDP) to test memory performance during sevoflurane and propofol anaesthesia in relation to hypnotic depth.

Material and methods

One hundred participants anaesthetised for elective surgery (50 with propofol and 50 with sevoflurane) and 50 non-anaesthetized listened to a list of words. The bispectral index (BIS) of the anaesthetised patients was recorded. Within 36 h after word presentation, memory was assessed using a word stem completion task, based on Buchner''s model applied on the PDP.

Results

There was evidence of memory for words presented during light (BIS 61-80) (p = 0.001) and adequate (BIS 41-60) (p = 0.008) but not deep anaesthesia (BIS 21-40) (p = 0.09). The PDP showed a significant implicit but not explicit memory contribution (mean total explicit memory scores: 0.04 ±0.07 in all BIS categories; mean implicit memory scores: 0.01 ±0.04, 0.1 ±0.08, and 0.05 ±0.09 at BIS = 21-40, 41-60, and 61-80, respectively). There was a statistically significant difference between the mean implicit memory score (I) of the propofol and sevoflurane group in the BIS category 41-60 in general (p = 0.016), and after incision (I_A.I.) (p = 0.005) in particular, with propofol depressing I more than sevoflurane in both cases. Memory performance of nonanaesthetized participants was better, with a higher contribution of explicit and a comparable contribution of implicit memory.

Conclusions

During general anaesthesia, implicit memory persists even in adequate hypnotic states. Sevoflurane affects the implicit memory of adequately anaesthetised subjects less than propofol.     

The Concept of Dissociation in Early Psychoanalytic Writers

ABSTRACT

The concept of dissociation in early psychoanalytic writing is examined in order to show the intimate connection between old and new theories and how they have been transformed through time and different models. Contemporary work on trauma and dissociation may be seen as an illustration of, and developing from, early psychoanalytic formulations on the organization of the personality. These pioneering ideas constitute an encompassing theory of the personality from which treatment of trauma is easily deduced. Psychoanalysis in the United States, which remained loyal to Freudian models, is contrasted with the British Object Relations School. The term, “dissociation,” has a variety of connotations: (1) observable clinical phenomena, i.e., symptoms; (2) a general principle of psychic organization; (3) loosely, several defense mechanisms; (4) a synonym for splitting, mainly within British Object Relations; and (5) the clinical presentation and psychodynamic understanding of multiple personality or dissociative identity disorder. This plurality of concepts may conspire against scientific integration, perpetuating a confusion between the differing uses. Alternatively, it can enrich our theories, provided we do not loose sight of the models that make terms meaningful. The various senses of the word, and the relevant theoretical frameworks, are illustrated with a case example.     

Therapeutic Hazards of Treating Child Alters as Real Children in Dissociative Identity Disorder

ABSTRACT

Dissociative identity disorder (DID), with its typical etiology of extreme, repetitive childhood trauma, usually includes manifestations of childlike ego-states, among others. For many patients, these ego-states, originating with the initial traumatic insults to the psyche in childhood, have been called forth again and again as new situations evoke the earlier trauma. When clinicians, family and friends react to them with warmth, nurturing, and empathy, this may exacerbate the illusion that such ego-states are indeed actual children. This can result in a patient becoming increasingly resistant to working through the issues and experiences by which these ego-states have become fixed, with the risk of therapy reaching an impasse. Attitudes, interventions, and approaches to move past such impasses are addressed.     

Fable or Fact?: Did Janet Really Come to Repudiate His Dissociation Theory?

ABSTRACT

Commencing in the late 1880s Pierre Janet developed the most complete theory of dissociation of his time. It has been suggested that Janet later repudiated his belief in dissociation theory (e.g., Hacking, 1995). Recently this viewpoint has been cited to support skepticism in dissociative identity disorder and researchers and clinicians of dissociation may be faced with such suggestions to challenge their work. The veracity of whether Janet actually recanted, or even lost interest in his dissociation theory is investigated through an examination of his later writings. Although Janet expanded his theoretical interests well beyond phenomena accounted for by dissociation, there is no evidence to indicate he renounced or lost confidence in his dissociation theory.     

Comparisons Between High and Low Peritraumatic Dissociators in Cardiovascular and Emotional Activity While Remembering Trauma

ABSTRACT

Peritraumatic dissociation (PD) is one of the best predictors of posttraumatic stress disorder (PTSD). In this pilot study, we examined cardiovascular psychophysiology and negative emotions in 19 adults who, retrospectively, reported experiencing high or low levels of PD during the worst trauma of their lives. In a contiguous series of ten-minute phases, they rested, thought about, talked about, and recovered from talking about their index trauma. We hypothesized that greater PD would be associated with more negative emotion, lower cardiovascular activity, and greater discordance between negative emotions and cardiovascular activity. Our main findings were that PD was associated with lower blood pressure prior to talking about the trauma, greater negative emotion while talking about the trauma, and greater emotional and cardiovascular discordance throughout the experiment. These findings add to the very limited empirical data on physiological concomitants of peritraumatic dissociation and may aid in developing preventive interventions for PTSD.     

Peritraumatic Dissociation Is Inversely Related to Catecholamine Levels in Initial Urine Samples of Motor Vehicle Accident Victims

ABSTRACT

This study was designed to determine the relationship between self-reports of peritraumatic dissociation during a motor vehicle accident and measures of physiological arousal in the immediate aftermath of the accident. Upon admittance to the hospital, 15-hour urine samples were collected from participants to measure levels of urinary catecholamines and cortisol. Within two days of the accident, participants reported symptoms of peritraumatic dissociation, and one month after the accident, 59 (34 male and 25 female) participants completed an interview designed to assess symptoms of PTSD. Results revealed that patients who subsequently developed PTSD reported significantly higher levels of peritraumatic dissociation than victims who did not develop PTSD, and that dissociation was negatively associated with levels of urinary norepinephrine and epinephrine. Dissociation was not related to urinary cortisol or cardiovascular levels upon admission. These findings are consistent with previous research that has suggested that high dis-sociators may constitute a subgroup of trauma victims who are physiologically less reactive to trauma.     

Peritraumatic Somatoform and Psychological Dissociation in Relation to Recall of Childhood Sexual Abuse

Abstract

Objective: Overwhelming experience can evoke psychological dissociation during or immediately after the event, including dissociative amnesia. Whereas some data suggest that such peritraumatic dissociation can also find expression in somatoform symptoms, only a limited range of such symptoms has been systematically studied. The present study hypothesized that peritraumatic psychological and somatoform dissociation are associated with each other, with delayed recall of childhood sexual abuse (CSA), and with CSA severity. Because current somatoform dissociation is most strongly associated with recalled childhood physical abuse (CPA), we also hypothesized that peritraumatic somatoform dissociation is associated with reported CPA over and above CSA.

Method: Thirty-four Dutch women who reported CSA were interviewed using a modified version of the Traumatic Memory Inventory (TMI) which assesses the characteristics of traumatic memories. The participants also completed the Traumatic Experiences Checklist, the Peritraumatic Dissociation Experiences Questionnaire, and the Peritraumatic Somatoform Dissociation Questionnaire.

Results: Peritraumatic psychological and somatoform dissociation were associated with each other, with delayed recall of trauma, and with severity of reported CS A. Reported CPA predicted peritraumatic somatoform dissociation over and above the severity of CS A in terms of the acts involved. Approximately 44% of the women reported independent corroboration of the abuse. Similar proportions of delayed, partial, and continuous CSA memories were corroborated.

Conclusions: This retrospective study suggested that delayed recall of CSA is associated with peritraumatic dissociation and CSA severity. It also suggested that trauma-especially that which involves serious threat to the integrity of the body-may evoke somatoform dissociation. Based on patient report, delayed recall of some CSA memories was as accurate as continuous recall of CSA.     

Early results of reconstruction of the dorsal scapholunate ligament

Abstract

We present the clinical results of a study of chronic dynamic scapholunate (SL) dissociation treated by reconstruction of the dorsal SL ligament. A total of 35 patients who presented with chronic dynamic SL instability had the scapholunate ligament reconstructed with a tendon graft. Twenty-nine patients were available for follow-up evaluation after a minimal interval of 17 months (range 17–72). Patients' satisfaction was good in 26/29 patients. Postoperative range of movement was reduced in extension and improved for flexion and ulnar deviation. Mean wrist movements were 75% of those on the opposite side. Most patients had good pain relief and recovered their grip strength, and returned to their regular employment. Follow-up stress radiographs showed a reduction in the SL angle and gap. Reconstruction of the dorsal SL ligament provides sufficient restoration of stability, pain relief, and functional improvement of the wrist for patients with dynamic SL instability. Although the short-term results are encouraging, we think that this method should be verified by longer follow-up.