全文获取类型
收费全文 | 398642篇 |
免费 | 26768篇 |
国内免费 | 9223篇 |
专业分类
耳鼻咽喉 | 4592篇 |
儿科学 | 10489篇 |
妇产科学 | 7087篇 |
基础医学 | 31994篇 |
口腔科学 | 9736篇 |
临床医学 | 43735篇 |
内科学 | 50548篇 |
皮肤病学 | 5560篇 |
神经病学 | 21655篇 |
特种医学 | 9774篇 |
外国民族医学 | 45篇 |
外科学 | 44974篇 |
综合类 | 59903篇 |
现状与发展 | 20篇 |
一般理论 | 33篇 |
预防医学 | 40487篇 |
眼科学 | 7632篇 |
药学 | 34376篇 |
463篇 | |
中国医学 | 35299篇 |
肿瘤学 | 16231篇 |
出版年
2024年 | 1327篇 |
2023年 | 6738篇 |
2022年 | 11564篇 |
2021年 | 15706篇 |
2020年 | 14680篇 |
2019年 | 20236篇 |
2018年 | 17842篇 |
2017年 | 14950篇 |
2016年 | 12406篇 |
2015年 | 11669篇 |
2014年 | 23410篇 |
2013年 | 25293篇 |
2012年 | 21214篇 |
2011年 | 23447篇 |
2010年 | 19450篇 |
2009年 | 17332篇 |
2008年 | 16703篇 |
2007年 | 17328篇 |
2006年 | 15257篇 |
2005年 | 13303篇 |
2004年 | 10784篇 |
2003年 | 9482篇 |
2002年 | 7582篇 |
2001年 | 6739篇 |
2000年 | 5532篇 |
1999年 | 4834篇 |
1998年 | 3962篇 |
1997年 | 3767篇 |
1996年 | 3237篇 |
1995年 | 3076篇 |
1994年 | 2955篇 |
1993年 | 2391篇 |
1992年 | 2363篇 |
1991年 | 2053篇 |
1990年 | 1848篇 |
1989年 | 1576篇 |
1988年 | 1541篇 |
1987年 | 1311篇 |
1985年 | 4028篇 |
1984年 | 5007篇 |
1983年 | 3495篇 |
1982年 | 3995篇 |
1981年 | 3694篇 |
1980年 | 3296篇 |
1979年 | 3011篇 |
1978年 | 2640篇 |
1977年 | 1987篇 |
1976年 | 2219篇 |
1975年 | 1683篇 |
1974年 | 1468篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
151.
周新国 《南通大学学报(哲学社会科学版)》2003,19(3):24-28
张謇的教育思想十分丰富 ,并且具有鲜明的时代特点。他在江苏南通的教育实践成就卓著 ,极富特色。他较早地提出了教育为地方经济社会发展服务的思想 ,创造了“以实业辅助教育 ,以教育促进实业”的成功模式 ,反映了教育从边缘走向经济中心这一历史发展的趋势。张謇的教育思想与实践在近代中国教育史上有重要地位 相似文献
152.
153.
154.
Moussa Ndong Machiko Kazami Tsukasa Suzuki Mariko Uehara Shin-ichi Katsumata Hirohumi Inoue Ken-Ichi Kobayashi Tadahiro Tadokoro Kazuharu Suzuki Yuji Yamamoto 《Nutrition Research》2009,29(9):640-647
Iron deficiency (ID) is one of the most commonly known forms of nutritional deficiencies. Low body iron is thought to induce neurologic defects but may also play a protective role against cancer development by cell growth arrest. Thus, ID may affect cellular pathways controlling cell growth and proliferation, the mechanism of which is still not fully understood. The serine/threonine protein kinase Akt and its downstream target, the mammalian Target of Rapamycin (mTOR), is known to play a crucial role in the regulation of cell growth and survival. Therefore, we hypothesized that Akt/mTOR pathway could be influenced by ID. Three-week-old male Wistar-strain rats were divided into 3 groups and the 2 groups had free access to a control diet (C group) or an iron-deficient diet (D group). The third group (PF group) were pair-fed the control diet to the mean intake of the D group. After 4 weeks, rats were killed and their brains were sampled. In separate experiments, COS-1 cells were cultured with or without the iron chelator deferoxamine. Western blots of brain samples and COS-1 lysates were used to analyze the expression and phosphorylation state of Akt, TSC2, mTOR, and S6 kinase proteins implicated in the Akt/mTOR pathway. Using 2 different ID models, we show for the first time that iron deficiency depresses Akt activity in rats and in COS-1 cells, leading to a decrease in mTOR activity. 相似文献
155.
156.
Robert M. Levy Roman Saikovsky Evgeniya Shmidt Alexander Khokhlov Bruce P. Burnett 《Nutrition Research》2009
Flavocoxid (Limbrel), a proprietary mixture of flavonoid molecules (baicalin and catechin), was tested against a traditional nonsteroidal anti-inflammatory drug, naproxen, for the management of the signs and symptoms of moderate osteoarthritis (OA) in humans. Discomfort and global disease activity were used as the primary end points, and safety assessments were also taken for both treatments as a secondary endpoint. In this double-blind study, 103 subjects were randomly assigned to receive either flavocoxid [500 mg twice daily (BID)] or naproxen (500 mg BID) in a 1-month onset of action trial. Outcome measures included the short Western Ontario and McMaster University Osteoarthritis Index, subject Visual Analogue Scale for discomfort and global response, and investigator Visual Analogue Scale for global response and fecal occult blood. Both flavocoxid and naproxen showed significant reduction in the signs and symptoms of knee OA (P ≤ .001). There were no statistically detectable differences between the flavocoxid and naproxen groups with respect to any of the outcome variables. Similarly, there were no statistically detectable differences between the groups with respect to any adverse event, although there was a trend toward a higher incidence of edema and nonspecific musculoskeletal discomfort in the naproxen group. In this short-term pilot study, flavocoxid was as effective as naproxen in controlling the signs and symptoms of OA of the knee and would present a safe and effective option for those individuals on traditional nonsteroidal anti-inflammatory drugs or cyclooxygenase-2 inhibitors. A low incidence of adverse events was reported for both groups. 相似文献
157.
M. Mizuguchi H. Yamanouchi T. Ichiyama M. Shiomi 《Acta neurologica Scandinavica》2007,115(S186):45-56
Acute encephalopathy is the most serious complication of pediatric viral infections, such as influenza and exanthem subitum. It occurs worldwide, but is most prevalent in East Asia, and every year several hundreds of Japanese children are affected by influenza-associated encephalopathy. Mortality has recently declined, but is still high. Many survivors are left with motor and intellectual disabilities, and some with epilepsy. This article reviews various syndromes of acute encephalopathy by classifying them into three major categories. The first group caused by metabolic derangement consists of various inherited metabolic disorders and the classical Reye syndrome. Salicylate is a risk factor of the latter condition. The second group, characterized by a systemic cytokine storm and vasogenic brain edema, includes Reye-like syndrome, hemorrhagic shock and encephalopathy syndrome, and acute necrotizing encephalopathy. Non-steroidal anti-inflammatory drugs, such as diclofenac sodium and mephenamic acid, may aggravate these syndromes. Severe cases are complicated by multiple organ failure and disseminated intravascular coagulation. Mortality is high, although methylprednisolone pulse therapy may be beneficial in some cases. The third group, characterized by localized edema of the cerebral cortex, has recently been termed acute encephalopathy with febrile convulsive status epilepticus, and includes hemiconvulsion-hemiplegia syndrome and acute infantile encephalopathy predominantly affecting the frontal lobes. Theophylline is a risk factor of these syndromes. The pathogenesis is yet to be clarified, but an increasing body of evidence points to excitotoxicity and delayed neuronal death. 相似文献
158.
扩髓交锁髓内钉治疗股骨、胫骨干骨折 总被引:7,自引:2,他引:5
目的探讨交锁髓内钉治疗股骨、胫骨干骨折的临床效果.方法应用交锁髓内钉治疗不同类型的股骨干骨折18例,胫骨干骨折15例.结果33例患者随访8~24个月,平均15.2个月,33例均骨性愈合.未出观畸性愈合、再骨折、断钉及膝、踝关节僵硬等并发症.结论交锁髓内钉治疗股骨、胫骨干骨折治愈率高,并发症少,效果满意. 相似文献
159.
中医情志的发生机制刍议 总被引:1,自引:0,他引:1
在情志学说和脑主神明理论指导下对情志产生的生理机制作新的诠释。认为脑神的气化出入及整合作用是情志发生的生理基础 ;五脏所化的气血精津为情志发生的物质基础 相似文献
160.
目的探讨初次献血对红细胞膜Na+-K+-ATP酶活性的影响.方法应用比色法分别检测50例符合献血条件的健康初次献血者献血前后的红细胞膜Na+-K+-ATP酶活性,并对结果进行分析.结果初次献血者献血前后红细胞膜Na+-K+-ATP酶活性分别为3.121±0.441和2.907±0.397 μmol.Pi/107 RBC.h,两者比较无明显差异(P>0.05).结论初次献血对红细胞膜Na+-K+-ATP酶活性无影响,献血不会造成红细胞功能损伤. 相似文献