全文获取类型
收费全文 | 525篇 |
免费 | 40篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 30篇 |
基础医学 | 28篇 |
口腔科学 | 1篇 |
临床医学 | 93篇 |
内科学 | 253篇 |
神经病学 | 1篇 |
特种医学 | 18篇 |
外科学 | 42篇 |
综合类 | 57篇 |
现状与发展 | 1篇 |
预防医学 | 11篇 |
药学 | 22篇 |
中国医学 | 1篇 |
肿瘤学 | 14篇 |
出版年
2024年 | 1篇 |
2023年 | 12篇 |
2022年 | 18篇 |
2021年 | 15篇 |
2020年 | 18篇 |
2019年 | 24篇 |
2018年 | 21篇 |
2017年 | 17篇 |
2016年 | 21篇 |
2015年 | 19篇 |
2014年 | 23篇 |
2013年 | 44篇 |
2012年 | 12篇 |
2011年 | 11篇 |
2010年 | 16篇 |
2009年 | 17篇 |
2008年 | 14篇 |
2007年 | 15篇 |
2006年 | 21篇 |
2005年 | 23篇 |
2004年 | 20篇 |
2003年 | 12篇 |
2002年 | 17篇 |
2001年 | 9篇 |
2000年 | 16篇 |
1999年 | 15篇 |
1998年 | 9篇 |
1997年 | 12篇 |
1996年 | 7篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 15篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1970年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有572条查询结果,搜索用时 0 毫秒
81.
82.
83.
84.
Rainer Wessely Marc Vorpahl Albert Schmig Karin Klingel 《Cardiovascular pathology》2004,13(6):327-329
Constrictive pericarditis (CP) is a highly relevant disease clinically because pericardiectomy represents the only curative therapeutic approach. Previous cardiac surgery or mediastinal radiation may cause CP, however, infectious agents account for a substantial portion of CP. In this report, we present a patient with previous biopsy-proven myocarditis and positive seroconversion against coxsackievirus B3 without clinical evidence of acute pericardial involvement who developed CP after a prolonged period of time. This suggests that infectious particles primarily infecting the myocardium may lead to chronic inflammatory responses of the pericardium, thus causing CP even at late clinical stages. This case emphasizes the important fact that primary myocarditis may not only cause systolic ventricular impairment but may also induce diastolic dysfunction of the heart, either as restrictive cardiomyopathy or, as in this case, through inflammatory involvement of the pericardium, leading to CP. 相似文献
85.
IntroductionLocalized pericardial constriction is a rare form of constrictive pericarditis CP. Depending on the CP location, clinical presentation may be variable, including compression and obstruction of right ventricular inflow tract(RVIT), coronary obstruction, or pulmonary stenosis.Case presentationA 72-year-old man presented a 2-year history of dyspnea and atrial fibrillation. A contrast enhanced angio computerized tomography clearly demonstrated a large spherical mass about 11 × 9 × 4 cm in the anterior pericardium, presenting as a mediastinal tumor causing compression and obstruction of the RVIT. The patient underwent surgical procedure. The outer calcified layer of the pericardial mass was a thick layer of calcification surrounding an inner amorphous low density material. The inferior calcified layer of the pericardial mass which was extremely adherent with the epicardium, was carefully excised, without employment of cardiopulmonary bypass, from the aorta and pulmonary artery origin to the diaphragm and all areas between the right and left phrenic nerves. The final diagnosis was idiopathic CP.DiscussionThe clinical presentation was due to right ventricular free wall compression and obstruction of the RVIT by a giant calcified anterior cardiac mass. The differential diagnosis with other calcified masses in the anterior mediastinum such as teratoma, hemopericardium after blunt trauma and idiopathic or tuberculous CP should be considered.ConclusionHerein we report a very rare case with localized CP causing compression and obstruction of RVIT due to a giant anterior calcified cardiac mass, treated successfully with pericardectomy. Careful dissection is mandatory for a successful procedure. 相似文献
86.
目的:探讨心包剥离术对老年慢性缩窄性心包炎心钠素与内皮素变化的影响。方法:收集我院收治的慢性缩窄性心包炎患者66例,随机分为对照组和实验组,每组各33例,患者均给予相应治疗,对照组给予相应强心、扩血管药物,实验组患者行心包剥离术,治疗结束后,对所有患者的ANF、ET、血压以及临床治疗效果进行检测并比较。结果,与治疗前相比,治疗后两组患者ANF、ET、舒张压以及脉压水平均下降,收缩压水平升高(P<0.05);与对照组相比,实验组患者ANF、ET、舒张压以及脉压水平较低,收缩压水平较高(P<0.05);实验组患者治疗总有效率较高(P<0.05)。结论:心包剥离术能够降低慢性缩窄性心包炎患者ANF、ET、舒张压以及脉压水平,升高收缩压水平,临床疗效较好,对临床有指导意义。 相似文献
87.
Pericardial diseases are relatively common in clinical practice either as isolated diseases or part of an underlying or systemic disease. Recent advances in the diagnosis and treatment have greatly improved the clinical management and lead to consensus documents on multimodality imaging and new guidelines on the diagnosis and therapy of pericardial diseases.
The aim of the present paper is to summarize available evidence in order to provide an updated and comprehensive review on the recent advances in the management of pericardial diseases. 相似文献
88.
Jonathan C. Trent Theodore K. Lau Akira Kawashima 《The International Journal of Cardiac Imaging》2000,16(2):117-123
We present the radiographic, computed tomographic (CT), and magnetic resonance (MR) findings in a woman with constrictive pericarditis due to an embolized hypodermic needle. The chest films revealed pleural effusions but no foreign body. The CT showed pericardial thickening and a linear foreign body of metallic attenuation in the right ventricular apex, and MR imaging revealed a signal void with magnetic susceptibility artifact. This case illustrates the capabilities and limitations of CT and MR imaging in hypodermic needle-induced constrictive pericarditis. 相似文献
89.
Serum cardiac troponin I and ST-segment elevation in patients with acute pericarditis. 总被引:2,自引:2,他引:0
E Bonnefoy P Godon G Kirkorian M Fatemi P Chevalier P Touboul 《European heart journal》2000,21(10):832-836
OBJECTIVE: ST-segment elevation in acute pericarditis is believed to be caused by superficial myocardial inflammation or epicardial injury. We used cardiac troponin I, a sensitive and specific marker of myocardial injury, to assess myocardial lesions in idiopathic acute pericarditis and its relationship to ST-segment elevation. PATIENTS AND METHODS: Sixty-nine consecutive patients (53 men, 48+/-17 years) with idiopathic acute pericarditis were included. We used an enzymoimmunoflurometric method to measure serum cardiac troponin I on admission (myocardial infarction threshold was 1.5 ng. ml(-1)). RESULTS: Cardiac troponin I was detectable in 34 patients (49%) and was beyond the 1.5 ng. ml(-1)threshold in 15 (22%). Coronary angiography performed in seven of these 15 patients was normal in all of them. ST-segment elevation was observed in 93% of the patients with cardiac troponin I >1.5 ng. ml(-1)vs 57% of those without (P<0.01). Sensitivity of ST-segment elevation to detect myocardial injury was 93% and specificity 43%. Patients with a cardiac troponin I increase higher than 1.5 ng. ml(-1)were more likely to have had a recent infection (66% vs 31%;P=0.01) and were younger (37+/-14 vs 52+/-16 years;P=0.002). There was no significant relationship with other parameters such as pericardial friction rub, fever, PR segment abnormalities, echocardiographic findings or C-reactive protein. CONCLUSION: In patients with idiopathic acute pericarditis, an increase in cardiac troponin I is frequently observed, especially in younger patients and those with a recent infection. Although ST-segment elevation does not reliably indicate myocardial injury, a significant cardiac troponin I increase is only seen in these patients. 相似文献
90.
Constrictive pericarditis. 总被引:6,自引:0,他引:6
The diagnosis of constrictive pericarditis remains a challenge because its physical findings and hemodynamics mimic restrictive cardiomyopathy. Various diagnostic advances over the years enable us to differentiate between these two conditions. This review begins with a case report of constrictive pericarditis, followed by a brief history and discussions of etiologies. Clinical features, radiologic, electrocardiographic, angiographic findings, and hemodynamics of constrictive pericarditis are reviewed. The echocardiographic findings are detailed and the recent advances in Doppler flow velocity patterns of pulmonary, mitral, tricuspid valves and hepatic veins are reported. Nuclear ventriculograms depict rapid ventricular filling in constrictive pericarditis and differentiate it from restrictive cardiomyopathy. Endomyocardial biopsy helps further in recognizing the various types of restrictive cardiomyopathies. Computed tomography and magnetic resonance imaging delineate abnormal pericardial thickness in constrictive pericarditis. Association of characteristic hemodynamic changes and abnormal pericardial thickness > 3 mm usually confirms the diagnosis of constrictive pericarditis. Effusive and occult varieties of constrictive pericarditis are briefly described. This review concludes with emphasizing the importance of pericardial resection. 相似文献