全文获取类型
收费全文 | 37366篇 |
免费 | 2796篇 |
国内免费 | 1283篇 |
专业分类
耳鼻咽喉 | 510篇 |
儿科学 | 369篇 |
妇产科学 | 242篇 |
基础医学 | 7275篇 |
口腔科学 | 973篇 |
临床医学 | 3189篇 |
内科学 | 5168篇 |
皮肤病学 | 300篇 |
神经病学 | 4906篇 |
特种医学 | 1596篇 |
外国民族医学 | 1篇 |
外科学 | 5807篇 |
综合类 | 4035篇 |
现状与发展 | 6篇 |
预防医学 | 1314篇 |
眼科学 | 647篇 |
药学 | 3486篇 |
7篇 | |
中国医学 | 1116篇 |
肿瘤学 | 498篇 |
出版年
2024年 | 106篇 |
2023年 | 587篇 |
2022年 | 1063篇 |
2021年 | 1392篇 |
2020年 | 1308篇 |
2019年 | 1229篇 |
2018年 | 1221篇 |
2017年 | 1073篇 |
2016年 | 977篇 |
2015年 | 1079篇 |
2014年 | 1891篇 |
2013年 | 2258篇 |
2012年 | 1777篇 |
2011年 | 1960篇 |
2010年 | 1700篇 |
2009年 | 1710篇 |
2008年 | 1645篇 |
2007年 | 1758篇 |
2006年 | 1513篇 |
2005年 | 1338篇 |
2004年 | 1233篇 |
2003年 | 1226篇 |
2002年 | 1021篇 |
2001年 | 851篇 |
2000年 | 741篇 |
1999年 | 688篇 |
1998年 | 785篇 |
1997年 | 779篇 |
1996年 | 651篇 |
1995年 | 568篇 |
1994年 | 501篇 |
1993年 | 457篇 |
1992年 | 444篇 |
1991年 | 428篇 |
1990年 | 356篇 |
1989年 | 348篇 |
1988年 | 308篇 |
1987年 | 276篇 |
1986年 | 215篇 |
1985年 | 339篇 |
1984年 | 255篇 |
1983年 | 166篇 |
1982年 | 239篇 |
1981年 | 208篇 |
1980年 | 157篇 |
1979年 | 138篇 |
1978年 | 130篇 |
1977年 | 105篇 |
1976年 | 103篇 |
1975年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
目的 研究主、被动最大张口度(AMMO、PMMO)与颞下颌关节强直严重程度的关系。方法 选取28只健康雄性绵羊随机分为实验组和对照组,每组各14只。实验组绵羊双侧颞下颌关节模拟髁突矢状骨折,其中左侧翼外肌被切断以阻断其功能;对照组绵羊未进行手术。于术前及术后12、24周对所有绵羊体重、AMMO、PMMO、颞下颌关节形态学特点进行测量评估。结果 实验组只有右侧保留翼外肌功能的颞下颌关节发生了骨强直。术后12、24周,实验组绵羊AMMO、PMMO、极限距离均显著低于对照组,差异均有统计学意义(均P < 0.05)。实验组绵羊AMMO和PMMO与骨融合区宽度、长度、面积及钙化程度均呈负相关(均P < 0.05),其中骨融合区面积为主要影响因素(术后12、24周相关系数r分别为-0.94、-0.95)。结论 颞下颌关节强直动物模型中阻断翼外肌功能可阻止骨强直的发生;对于早期髁突矢状骨折,可通过牙合垫或牙合板进行张口训练,进而阻断翼外肌功能。当颞下颌关节发生骨强直时,骨融合区面积越大,张口受限越明显。 相似文献
12.
Aging alters bladder functions where a decrease in filling, storage and emptying is observed. These changes cause urinary incontinence, especially in women. The aim of this study is to examine how aging affects the intracellular calcium movements due to agonist-induced contractions in permeabilized female rat bladder. Urinary bladder isolated from young and old female Sprague-Dawley rats were used. Small detrusor strips were permeabilized with β-escin. The contractile responses induced with agonists were compared between young and old groups. Carbachol-induced contractions were decreased in permeabilized detrusor from old rats compared to young group. Heparin and ryanodine decreased carbachol-induced contractions in young rats where only heparin inhibited these contractions in olds. Caffeine-induced contractions but not inositol triphosphate (IP3)-induced contractions were decreased in old group compared to youngs. The cumulative calcium response curves (pCa 8–4) were also decreased in old rats. Carbachol-induced calcium sensitization responses did not alter by age where GTP-β-S and GF-109203X but not Y-27632 inhibited these responses. Carbachol-induced contractions decrease with aging in rat bladder detrusor. It can be postulated as IP3-induced calcium release (IICR) is primarily responsible for the contractions in older rats where the decrease in carbachol contractions in aging may be as a result of a decrease in calcium-induced calcium release (CICR), rather than carbachol-induced calcium sensitization. 相似文献
13.
《Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society》2020,28(11):1412-1426
14.
Naveen B.S. M.T. Mohan J. Tharayil S.T. Joseph 《International journal of oral and maxillofacial surgery》2021,50(8):1003-1008
A local pedicled vascularized bone flap can prevent the morbidity and cost of free bone flap surgery in small segmental bone defects or long cartilaginous defects of the head and neck. Such flaps can also be useful in patients who are high risk for surgery. The periosteal vascularity of the mandible can be used to design islanded facial artery-based bone flaps, which can be utilized to that extent. Two patients with a small segmental mandibulectomy defect and one patient with a long cricotracheal resection defect underwent reconstruction using three different designs of islanded facial artery osteomyomucosal/osseous flap (iFOMM). The patients had a minimum follow-up period of 18 months. All flaps were successful, with satisfactory healing and without any functional deficit or disease at last follow-up. 相似文献
15.
16.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献17.
18.
Stephan Koter Tina U. Cohnert Korbinian B. Hindermayr Jörg Lindenmann Maximilian Brückner Wolfgang K. Oswald Georg Werkgartner Doris Wagner 《Journal of vascular surgery》2019,69(4):1227-1232
Objective
Low psoas muscle area is shown to be an indicator for worse postoperative outcome in patients undergoing vascular surgical. Additionally, it has been associated with longer durations of hospital stay in patients with cancer who undergo surgery and subsequently greater health care costs in Europe and the United States. We sought to evaluate this effect on hospital expenditure for patients undergoing vascular repair in a health care system with universal access.Methods
Skeletal muscle mass was assessed on preoperative abdominal computed tomography scans of patients undergoing open aortic aneurysm repair in a retrospective fashion. The skeletal muscle index (SMI) was used to define low muscle mass. Health care costs were obtained for all patients and the relationship between a low SMI and higher costs was explored using linear regression and cross-sectional analysis.Results
We included 156 patients (81.5% male) with a median age of 72 years undergoing elective surgery for infrarenal abdominal aortic aneurysm in this analysis. The median SMI for patients with low skeletal muscle mass was 53.21 cm2/kg and for patients without, 70.07 cm2/kg. Hospital duration of stay was 2 days longer in patients with low skeletal muscle mass as compared with patients with normal (14 days vs 11 days; P = .001), as was duration of intensive care stay (3 days vs 1 day; P = .01). The median overall hospital costs were €10,460 higher for patients with a low SMI as compared with patients with a normal physical constitution (€53,739 [interquartile range, €45,007-€62,471] vs €43,279 [interquartile range, €39,509-€47,049]; P = .001). After confounder adjustment, a low SMI was associated with a 14.68% cost increase in overall hospital costs, for a cost increase of €6521.Conclusions
Low skeletal muscle mass is independently associated with higher hospital as well as intensive care costs in patients undergoing elective aortic aneurysm repair. Strategies to reduce this risk factor are warranted for these patients. 相似文献19.
20.
Mt D. Dbrssy Chockalingam Ramanathan Danesh Ashouri Vajari Yixin Tong Thomas Schlaepfer Volker A. Coenen 《The European journal of neuroscience》2021,53(1):89-113
Deep brain stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment‐resistant depressed patients—one of several targets under investigation—has shown to be promising in a number of uncontrolled open label trials. However, there are remain numerous questions that need to be investigated to understand and optimize the clinical use of DBS in depression, including, for example, the relationship between the symptoms, the biological substrates/projections and the stimulation itself. In the context of precision and customized medicine, the current paper focuses on clinical and experimental research of medial forebrain bundle DBS in depression or in animal models of depression, demonstrating how clinical and scientific progress can work in tandem to test the therapeutic value and investigate the mechanisms of this experimental treatment. As one of the hypotheses is that depression engenders changes in the reward and motivational networks, the review looks at how stimulation of the medial forebrain bundle impacts the dopaminergic system. 相似文献