两种胰肠吻合术式与胰瘘关系探讨

目的分析比较粘合式胰肠吻合方式与双层套入式吻合方式发生胰瘘并发症的差异。方法对1999年1月至2006年1月期间57例胰十二指肠切除术病例资料进行回顾性分析研究,依据术中胰肠吻合方式的不同,分为粘合式胰肠吻合组和双层套入式吻合组,比较两组间手术时间、出血量、平均住院时间和胰瘘发生率的差异。结果无手术死亡。两组手术时间、出血量和平均住院时间无统计学差异。套入式吻合组发生胰肠吻合口瘘1例(2.9%)、单纯性胰瘘6例(17.6%),粘合式吻合组无胰瘘发生。两组胰肠吻合口瘘差异无统计学意义(P>0.05),套入式吻合组单纯性胰瘘显著高于粘合式吻合组(P<0.05)。胰瘘经保守治疗均治愈。结论胰肠吻合术式对胰瘘发生率有一定的影响,粘合式胰肠吻合术式可以有效地降低胰瘘发生率。     

胰肠吻合方式与胰漏发生关系的研究

目的探讨胰十二指肠切除术胰肠吻合方式与胰漏发生的关系,以寻找预防胰漏的办法。方法2001年1月至2005年12月行胰十二指肠切除术胰肠吻合106例。其中行胰腺空肠端端套入吻合52例,胰腺-空肠端侧套入吻合31例,胰管与空肠黏膜吻合23例;胰管支撑胰液内引流101例,胰管支撑胰液外引流5例。所有病例均放置T管。结果术后出现胰漏11例,占10．4％,其中胰腺空肠端端吻合5例（9．6％）,胰腺空肠端侧吻合4例（12．9％）,胰管空肠黏膜对黏膜吻合2例（2／23）;胰管内放置支撑管胰液内引流101例、外引流5例,三种胰肠吻合方式的胰漏发生率差异无显著性意义（P〉0．05）,显示胰肠吻合方式与胰漏的发生无相关性。结论同一种吻合方式并不适用于所有病人,熟练掌握操作技术,积累丰富的临床经验,并根据具体情况选择相应的处理方法,才能将胰漏的发生率降到最低程度。     

改良彭氏Ⅱ型捆绑式吻合技术在基层医院应用体会

目的探讨基层医院开展改良彭氏Ⅱ型捆绑式胰肠吻合术在防止胰漏、减少并发症方面的临床价值。方法对9例患者采用改良彭氏Ⅱ型捆绑式吻合技术行一期胰十二指肠切除术。结果所有9例患者手术存活率100%,无胰漏、胆漏、腹腔出血等并发症。结论改良彭氏Ⅱ型捆绑式吻合技术能有效预防胰肠吻合口漏,值得在基层医院开展。     

Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy: An Up-to-date Meta-Analysis

Background: The reconstruction of the pancreas after pancreaticoduodenectomy (PD) is a crucial factor in preventing postoperative complications as pancreatic anastomosis failure is associated with a high morbidity rate and contributes to prolonged hospitalization and mortality. Several techniques have been described for the reconstruction of pancreatic digestive continuity in the attempt to minimize the risk of a pancreatic fistula. The aim of this study was to compare the results of pancreaticogastrostomy and pancreaticojejunostomy after PD. Methods: A systematic review and meta-analysis were conducted of randomized controlled trials (RCTs) published up to January 2015 comparing patients with pancreaticogastrostomy (PG group) versus pancreaticojejunostomy (PJ group). Two reviewers independently assessed the eligibility and quality of the studies. The meta-analysis was conducted using either the fixed-effect or the random-effect model. Results: Eight RCTs describing 1,211 patients were identified for inclusion in the study. The meta-analysis shows that the PG group had a significantly lower incidence rate of postoperative pancreatic fistulas [OR 0.64 (95% confidence interval 0.46–0.86), p = .003], intra-abdominal abscesses [OR 0.53 (95% CI, 0.33–0.85), p = .009] and length of hospital stay [MD ?1.62; (95% CI 2.63–0.61), p = .002] than the PJ group, while biliary fistula, mortality, morbidity, rate of delayed gastric emptying, reoperation, and bleeding did not differ between the two groups. Conclusion: This meta-analysis suggests that the most effective treatment for reconstruction of pancreatic continuity after pancreatoduodenectomy is pancreaticogastrostomy. However, the advantage of the latter could potentially be demonstrated through further RCTs, including only patients at high risk of developing pancreatic fistulas.     

捆绑式胰肠吻合术在重度胰腺损伤中的应用

目的 回顾性总结捆绑式胰肠吻合术在Ⅲ级以上胰腺损伤中的应用价值和治疗经验.方法 对1999年3月～2007年3月我院收治的18例Ⅲ级以上胰腺损伤患者实行捆绑式胰空肠Roux-Y吻合术.结果 全组术后无一例发生胰瘘等并发症,较多地保留了胰腺的组织和功能.结论 捆绑式胰肠吻合术在Ⅲ级以上胰腺损伤的治疗过程中,不仅可以预防胰瘘的发生,而且可以缩短手术时间,保留较多的胰腺组织和功能.     

羊肠线捆扎胰残端法在胰十二指肠切除术中的应用效果

目的研究应用羊肠线捆扎胰残端法在胰十二指肠切除术中的临床效果。方法将实施胰十二指肠切除的29例患者,在完成胰十二指肠切除及淋巴廓清后,将患者按2∶1随机分为研究组和对照组,研究组19例用0号羊肠线距胰残端2.5～3cm处捆扎胰残端,再行空肠单层套入式吻合,对照组10例行常规的胰空肠端端双层套入式吻合,2组术后进行临床效果对照。结果研究组19例术后无发生胰肠吻合口漏、胆漏及胰腺炎病例;对照组10例发生胰漏1例,胰周积液并感染1例。胰肠吻合时间研究组比对照组缩短近一半时间(P<0.01),胰腺残端失血量研究组明显比对照组减少(P<0.01)。结论应用羊肠线捆扎胰残端法可减少术中、术后胰腺残端出血,术野清晰,操作简便,节省时间,并可有效预防术后胰漏的发生。     

Blumgart吻合在胰十二指肠切除术后胰瘘防治中的作用

目的评价Blumgart吻合方法对胰十二指肠切除术后胰瘘及其他并发症发生的影响。方法回顾南京医科大学附属南京医院2005年1月-2011年12月实施胰十二指肠切除术的190例患者的临床资料。将患者按照不同的吻合方式为3组:Blumgart吻合组(A组)55例,胰管空肠黏膜端侧吻合组(B组)65例,套入式吻合组(C组)70例。比较不同吻合方法术后胰瘘及其他并发症的发生率。各组并发症发生率的比较采用行×列χ2检验。结果全部患者均无围手术期死亡,术后并发症发生率为48.4%(92/190),其中A组为25.5%(14/55),B组为52.3%(34/65),C组为62.9%(44/70),3组比较差异有统计学意义(χ2=17.850,P0.05)。术后胰瘘发生率20.5%(39/190),其中A组为5.5%(3/55),B组为20%(13/65),C组为32.9%(23/70)。在胰管内径3 mm的患者中,不同吻合方式的患者胰瘘发生率差异有统计学意义(χ2=6.089,P0.05),在≥3mm的患者时,不同吻合方式患者胰瘘的发生率差异无统计学意义(χ2=5.436,P0.05)。结论 Blumgart胰肠吻合方法安全、简单、省时,明显降低胰瘘的发生率,值得推广。     

Use of bromthymol blue, a pH indicator, for detecting the pancreatic duct orifice after resection of the head of the pancreats

Postoperative pancreatography after resection of the head of the pancreas often provides important morphologic information. However, the orifice of the residual pancreatic duct is often difficult to detect endoscopically. We evaluated the use of bromthymol blue (BTB), a pH indicator that changes color from orange to a purplish-blue when exposed to alkaline conditions, to assist in the detection of the postoperative orifice. Pancreatography was performed in 46 patients who underwent resection of the head of the pancreas, and the utility of BTB in identifying the orifice of the pancreatic duct during endoscopy was studied. Twenty-one patients underwent endoscopy with the use of BTB. The series consisted of 8 patients who had received a pyloruspreserving pancreaticoduodenectomy with a pancreaticogastrostomy (PPPD-PG), 6 patients who had had pyloruspreserving pancreaticoduodenectomy with a pancreaticojejunostomy (PPPD-PJ), and 7 patients who had undergone a duodenum-preserving resection of the head of the pancreas with a pancreaticoduodenostomy (DPPHR-PD). The remaining 25 patients underwent conventional pancreatography without the use of BTB. This group consisted of 12 patients given a PPPD-PG, 6 patients who had received a PPPD-PJ, and 7 patients who had undergone a DPPHR-PD. The success of the postoperative endoscopic pancreatography was compared in the two groups. In all 21 patients, postoperative pancreatography with BTB resulted in a success rate of 100%, compared to success in only 10 patients who had conventional endoscopy (success rate 40%). This study demonstrated that the use of BTB significantly enhanced the success rate of endoscopic retrograde pancreatography after resection of the head of the pancreas.     

两种捆绑式吻合术对胰十二指肠切除术患者疗效及术后胰瘘的影响

目的探讨两种捆绑式吻合术对胰十二指肠切除术(PD)患者疗效及术后胰瘘的影响。方法回顾性分析2016年1月至2018年12月西安交通大学第一附属医院收治的140例PD患者的临床资料,按照手术方式的不同分为BPG组(行捆绑式胰胃吻合手术)74例和BPJ组(行捆绑式胰肠吻合手术)66例。比较2组患者围手术期指标(手术时间、术中出血量、吻合时间、住院时间),评估术前、术后10 d胰腺功能(血清淀粉酶、脂肪酶、糖化血红蛋白)、胃功能(胃泌素、胃动素),记录2组患者术后并发症发生率。结果BPG组吻合时间短于BPJ组,差异有统计学意义(P<0.05);2组患者手术时间、术中出血量、住院时间比较,差异无统计学意义(P>0.05);术后10 d,2组患者血清淀粉酶、脂肪酶、胃泌素、胃动素水平均低于术前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);术后10 d,2组患者糖化血红蛋白与术前比较,差异均无统计学意义(P>0.05),组间比较差异无统计学意义(P>0.05);患者胰瘘、胃排空障碍、术后出血、切口感染等并发症发生率组间比较,差异均无统计学意义(P>0.05)。结论BPG与BPJ均可应用于PD患者,但BPG术式吻合时间更短,操作难度更小。     

A Comparative Study Between Longitudinal Pancreacticojejunostomy v/s Lateral Pancreaticogastrostomy as a Drainage Procedure for Pain Relief in Chronic Pancreatitis Done in a Tertiary Referral Centre of Eastern India

Chronic pancreatitis (CP) is a chronic inflammation of pancreas that leads to progressive fibrosis of pancreatic parenchyma. Commonest indication of surgery in chronic pancreatitis is intractable pain. Choice of procedure depends upon the main pancreatic duct (MPD) morphology. Decompression is useful in dilated and obstructed ducts. Traditional form of decompression is construction of a pancreatico-jejunal anastomosis (LPJ). Another method to achieve ductal decompression is by a pancreaticogastrostomy (LPG) and this study will try to evaluate its effectiveness against pancreaticojejunostomy. To compare the effectiveness of LPG and LPJ in relieving intractable abdominal pain in patients with CP and their respective post-operative complications. This prospective study was done over a period of 4 years from Jan 2007 to Dec 2010 at IPGME & R (SSKM), a tertiary hospital of eastern India. Patients with diagnosis of CP with or without duct calculi and MPD diameter ≥7 mm with intractable pain were included. 70 patients were randomly allocated for LPJ and LPG operation by lottery method. Study tools were questionnaires, blood and radiological investigations and standard instruments for open surgery. The patients were prospectively analyzed for duration of surgery and hospital stay, operative/postoperative complications and assessment of postoperative pain relief. Pain relief was assessed as complete (no analgesic requirement), satisfactory (tolerable pain with normal daily activities) and unsatisfactory (hospitalization, narcotics or hampered daily activities). 1. Operative time was shorter in LPG than LPJ (Median 85 vs. 110 min). 2. Incidence of ileus was lesser in LPG group (p = .054). Other complications were comparable in both groups. 3. LPG was associated with shorter duration of hospital stay (Mean 6 vs. 8 days). 4. Pain relief was comparable in LPG and LPJ. LPG is a good alternative to LPJ for CP.