捆绑式胰空肠吻合在胰十二指肠切除术中的临床应用

目的探讨捆绑式胰空肠吻合在胰十二指肠切除术中的临床应用的安全可行性。方法回顾分析2000年8月至2008年12月本院胰十二指肠切除术采用彭氏捆绑式胰空肠吻合术47例的临床资料。结果本组47例手术均顺利完成,均无胰肠吻合口漏、胆漏、胃肠吻合口漏。全部患者均痊愈出院。随访38例3-10个月,B超、CT检查胰腺残端附近无积液。结论胰十二指肠切除术中采用捆绑式胰空肠吻合能起到避免吻合口胰漏的发生,是一种安全可行的术式。     

Tailored resective pancreatic surgery for pediatric patients with chronic pancreatitis

Background

Surgical treatment for chronic pancreatitis (CP) in children comprises predominantly nonresective draining procedures. The purpose of this study was to identify indications, techniques, and results of organ-preserving resective pancreatic procedures for pediatric CP at our institution.

Patients and Methods

A retrospective chart review was performed of all children undergoing pancreatic surgery for CP over a period of 4 years.

Results

Overall, 6 pediatric patients (3 male, 3 female, ages 7-18 years) underwent a duodenum-preserving pancreatic head resection (3), a middle segmental pancreatic resection (2), or a distal pancreatectomy (1) for CP of different etiologies (idiopathic 2, posttraumatic 2, pancreas divisum 1, situs inversus 1). No mortality or major surgical complication occurred. Mean operative time was 294 min (207-412 min) and intraoperative blood loss was 541 mL (100-1300 mL). Postoperative hospital stay was 13 days (10-18 days). No endocrine or exocrine insufficiency occurred during follow up of 46 months (25-50 m), and pain control was improved in 5 of 6 patients.

Conclusions

Tailored organ-preserving resective pancreatic surgery can be performed with low morbidity and mortality in pediatric patients with CP and not responding to conservative treatment.     

根据胰管直径等因素选择不同胰肠吻合方式对患者术后恢复的影响

目的 评价根据胰管直径等因素选择的不同胰肠吻合方式对患者术后恢复的影响,为胰肠吻合方式的选择决策提供依据.方法 回顾性分析我院在2010年1月至2013年1月间行胰十二指肠切除术305例患者的临床资料.对于胰管直径≥3 mm的患者采用胰管空肠黏膜吻合（胰管空肠吻合组,120例）;对于胰管直径＜3 mm者,进一步比较胰腺残端与空肠管径的直径大小,若胰腺残端较粗大,且大于空肠管径者采用改良Child胰肠吻合（改良Child胰肠吻合组,80例）,若胰腺残端直径小于空肠管径者选择捆绑式胰肠吻合（捆绑式胰肠吻合组,105例）.比较不同胰肠吻合方式术后并发症的发生率,评价临床疗效.结果 胰管空肠黏膜吻合组胰管直径显著大于其他两组（P＜ 0.05）,改良Child胰肠吻合组胰腺残端直径明显大于捆绑式胰肠吻合组（P＜0.05）.本组研究总体胰瘘发生率为11.1％ （34/305）.比较三组患者术后胰瘘、腹腔出血、腹腔感染、消化功能异常、平均住院时间及术后死亡,差异无统计学意义（χ^2=1.51,2.78,1.16,3.75,1.94,F=2.13,P＞0.05）.结论 在行胰十二指肠切除术时,可以根据胰管直径、胰腺残端直径及空肠管径合理选择不同的胰肠吻合方式.     

PANCREATICODUODENECTOMY: DOES PREOPERATIVE BILIARY DRAINAGE,METHOD OF PANCREATIC RECONSTRUCTION OR AGE INFLUENCE PERIOPERATIVE OUTCOME? A RETROSPECTIVE STUDY OF 104 CONSECUTIVE CASES

BACKGROUND: Whether preoperative biliary drainage (PBD) is beneficial in reducing complications after pancreaticoduodenectomy is controversial. There remains a reluctance to consider pancreaticoduodenectomy in older patients. The major source of morbidity and potential mortality after pancreaticoduodenectomy is pancreatic fistula, which is caused by difficulties associated with the pancreatic anastomosis. The purpose of this study was to examine the effect of PBD, patient age and method of pancreatico-enteric reconstruction on postoperative morbidity and mortality. METHODS: A total of 104 consecutive patients undergoing pancreaticoduodenectomy between November 1992 and November 2004 were identified from a prospectively collected database. Multiple preoperative and intraoperative variables were examined and their relationship to postoperative outcome was analysed. RESULTS: Postoperative mortality was <1%. Forty-three patients (43%) suffered a total of 85 complications. Median length of stay was 12.5 days (range, 1-88 days). The group undergoing PBD did not have higher rates of infectious complication (12 vs 19%; P = 0.34) or overall complication (41 vs 42%; P = 0.88) compared with the undrained group. Rate of anastomotic leak (18 vs 4%; P = 0.045) and anaemia requiring transfusion (41 vs 9%; P = 0.001) were significantly higher in the pancreaticojejunostomy group compared with the pancreaticogastrostomy group. Patients over the age of 70 years did not have higher rates of complication (44 vs 41%, P = 0.5) or postoperative length of stay. CONCLUSION: Preoperative biliary drainage was not associated with increased postoperative complications. Pancreaticogastrostomy after pancreaticoduodenectomy is a safe and reliable method of reconstruction. Finally, pancreaticoduodenectomy can be carried out with acceptable rates of postoperative morbidity and mortality in selected patients over 70 years of age.     

胰肠吻合方式对胰十二指肠切除术后胰瘘的影响

目的：探讨胰肠吻合方式对胰十二指肠切除术后胰瘘的影响。方法：回顾性分析2008年10月至2013年8 月天津医科大学肿瘤医院收治的145 例术前诊断为壶腹周围肿瘤行胰十二指肠切除术患者的临床资料。对影响术后胰瘘发生的相关因素进行统计分析。结果：本组患者中27例术后发生胰瘘。在4 种胰肠吻合方式中,胰管空肠黏膜吻合和Blumgart 吻合的胰瘘发生率低,且皆无C 级胰瘘。多因素分析应用Logistic回归,结果表明不同的胰肠吻合方式及性别为术后胰瘘发生的独立预后因素。结论：胰肠吻合方式是影响胰十二指肠切除术后胰瘘发生的危险因素。