全文获取类型
收费全文 | 4589篇 |
免费 | 563篇 |
国内免费 | 72篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 85篇 |
妇产科学 | 87篇 |
基础医学 | 727篇 |
口腔科学 | 131篇 |
临床医学 | 587篇 |
内科学 | 438篇 |
皮肤病学 | 53篇 |
神经病学 | 239篇 |
特种医学 | 84篇 |
外科学 | 516篇 |
综合类 | 518篇 |
预防医学 | 681篇 |
眼科学 | 40篇 |
药学 | 538篇 |
17篇 | |
中国医学 | 270篇 |
肿瘤学 | 182篇 |
出版年
2024年 | 16篇 |
2023年 | 73篇 |
2022年 | 188篇 |
2021年 | 202篇 |
2020年 | 189篇 |
2019年 | 183篇 |
2018年 | 223篇 |
2017年 | 217篇 |
2016年 | 170篇 |
2015年 | 162篇 |
2014年 | 295篇 |
2013年 | 359篇 |
2012年 | 245篇 |
2011年 | 258篇 |
2010年 | 209篇 |
2009年 | 181篇 |
2008年 | 169篇 |
2007年 | 188篇 |
2006年 | 174篇 |
2005年 | 164篇 |
2004年 | 127篇 |
2003年 | 123篇 |
2002年 | 108篇 |
2001年 | 74篇 |
2000年 | 53篇 |
1999年 | 48篇 |
1998年 | 45篇 |
1997年 | 59篇 |
1996年 | 46篇 |
1995年 | 54篇 |
1994年 | 52篇 |
1993年 | 44篇 |
1992年 | 44篇 |
1991年 | 40篇 |
1990年 | 39篇 |
1989年 | 23篇 |
1988年 | 23篇 |
1987年 | 25篇 |
1986年 | 28篇 |
1985年 | 53篇 |
1984年 | 55篇 |
1983年 | 39篇 |
1982年 | 44篇 |
1981年 | 46篇 |
1980年 | 25篇 |
1979年 | 14篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1975年 | 2篇 |
排序方式: 共有5224条查询结果,搜索用时 0 毫秒
91.
目的:探讨裸花紫珠片和痔宁片治疗I期内痔出血的临床效果。方法:我院收治的I期内痔出血患者120例,随机分为实验组(n=60例)服用裸花紫珠片,对照组(n=60例)服用痔宁片,两组同时配合使用化痔栓。比较两组治疗效果,治疗后白细胞计数和凝血时间改变。观察药物副作用。结果:实验组治疗后55例有效(91.67%),显著高于对照组的81.67%(P〈0.05)。实验组治疗后白细胞计数减少,血小板量增加,凝血时间比治疗前缩短,与对照组差异有统计学意义(P〈0.05)。两组均未观察到副作用。结论:裸花紫珠片治疗I期内痔出血具有较好的止血作用,可在临床用药中推广。 相似文献
92.
93.
目的:用非线性混合效应模型(NONMEM)估算环孢素2种制剂在人体的相对生物利用度和药动学参数。方法: 20名男性志愿者随机、交叉单次口服环孢素微乳剂和普通乳剂500mg。HPLC法测定血药浓度。经典药动学方法和NONMEM法估算相对生物利用度和药动学参数。结果:用NONMEM法估算环孢素微乳剂生物利用度是普通乳剂的(209±s60) %;普通乳剂和微乳剂的V/F分别是(0. 30±0. 10), (0. 14±0. 06)L;Ka分别是0. 40±0. 11, 0. 9±0. 5;Ke分别是0. 16±0. 18, 0. 32±0. 13;K12分别是0. 23±0. 17, 0. 20±0. 17;K21分别是0. 021±0. 021, 0. 17±0. 08, 与传统方法相比基本一致。结论:NONMEM法为药物生物利用度评价和药动学参数计算提供一种简捷和快速的数据分析途径。 相似文献
94.
95.
Introduction: The dual leucine zipper kinase (DLK, MAP3K12) is essential for neuronal development and has been shown to mediate axon regeneration. On the other hand, DLK is involved in the pathogenesis of neurodegenerative disease and diabetes mellitus. Several patents have been published claiming to modulate or inhibit DLK by various approaches including ATP competitive inhibitors. In addition, two publications describe SAR of highly selective DLK inhibitors with efficacy in distinct mouse models of neurodegeneration.Areas covered: This review summarized patents claiming to modulate DLK activity published between 2010 and 2015. Peer-reviewed publications related to the patents and additional peer-reviewed publications are included. This article describes 18 patents from three pharmaceutical companies and three academic research groups.Expert opinion: Several methods are proposed to modulate DLK activity, some of them very experimental and not suitable for easy application in patients. ATP competitive kinase inhibitors exert high affinity, but for the majority, no information about their selectivity is available. To date, two inhibitors have been tested in mice. Given the controversial findings that DLK is required for neurodegeneration and for axon regeneration, more research is needed to further elucidate the regulation and the function of this kinase in diverse organs/tissues and under physiological and pathological conditions. 相似文献
96.
97.
目的研究血中有机磷混配农药的气相色谱检测方法及血液灌流对毒物的定量清除效率。方法模拟临床血液灌流装置,对含有机磷混配农药的血样进行灌流吸附,用毛细管气相色谱法测定混配农药各单体的残留量。结果低、中、高三种浓度的加标回收率为89.3%~104.4%,相对标准偏差为2.2%~11.6%。灌流前敌敌畏浓度为9.84μg/ml,甲基对硫磷为9.96μg/ml,在灌流3.0h后,血中残留敌敌畏浓度和清除速率分别是0.68μg/ml~1.59μg/ml、13.7μg/min~15.2μg/min;甲基对硫磷分别为0.20μg/ml~0.59μg/ml、15.6μg/min~16.1μg/min。结论包膜活性炭血液灌流能清除血液中大部分农药,迅速降低血中混配农药各单体的浓度。但是要根据中毒程度选择合适的灌流时间和包膜活性炭用量。 相似文献
98.
Mandefrot Dubale Milica Vidak Vasi Gaurav Goel Ajay Kalamdhad Laishram Boeing Singh 《Materials》2023,16(1)
The European Green Deal, which emphasizes zero-waste economies, and waste recycling in construction and building materials, has arisen due to significant worldwide needs for solid waste recovery and usage. This ambitious study focuses on recycling mixed construction and demolition (C&D) waste into burnt bricks and investigating the influence of firing temperature. While pursuing its objectives, this is dependent on raw material characterization and burnt-brick product quality assessment. The recycling of mixed C&D waste is explored by mixing the waste into two soil types (alluvial and laterite) in ratios ranging from 5% to 45% at three firing temperatures (700 °C, 850 °C and 900 °C). The utilization of mixed C&D waste in amounts of 10% at 700 °C and 25% at 850 °C and 900 °C fulfilled the Indian standard. Although a fire at 700 °C results in less optimal waste utilization, it is beneficial and recommended for reducing the carbon footprint and energy use. Additional mineralogical and microstructural analyzes are performed on the optimal fired samples. The study’s findings are promising for sustainable resource usage, reducing carbon footprint, and reducing waste disposal volume. This research is a big step toward the Sustainable Development Goals of the United Nations and a circular economy. 相似文献
99.
Chongliang Luo Md Nazmul Islam Natalie E Sheils John Buresh Martijn J Schuemie Jalpa A Doshi Rachel M Werner David A Asch Yong Chen 《J Am Med Inform Assoc》2022,29(8):1366
ObjectiveTo develop a lossless distributed algorithm for generalized linear mixed model (GLMM) with application to privacy-preserving hospital profiling.Materials and MethodsThe GLMM is often fitted to implement hospital profiling, using clinical or administrative claims data. Due to individual patient data (IPD) privacy regulations and the computational complexity of GLMM, a distributed algorithm for hospital profiling is needed. We develop a novel distributed penalized quasi-likelihood (dPQL) algorithm to fit GLMM when only aggregated data, rather than IPD, can be shared across hospitals. We also show that the standardized mortality rates, which are often reported as the results of hospital profiling, can also be calculated distributively without sharing IPD. We demonstrate the applicability of the proposed dPQL algorithm by ranking 929 hospitals for coronavirus disease 2019 (COVID-19) mortality or referral to hospice that have been previously studied.ResultsThe proposed dPQL algorithm is mathematically proven to be lossless, that is, it obtains identical results as if IPD were pooled from all hospitals. In the example of hospital profiling regarding COVID-19 mortality, the dPQL algorithm reached convergence with only 5 iterations, and the estimation of fixed effects, random effects, and mortality rates were identical to that of the PQL from pooled data.ConclusionThe dPQL algorithm is lossless, privacy-preserving and fast-converging for fitting GLMM. It provides an extremely suitable and convenient distributed approach for hospital profiling. 相似文献
100.
目的 观察复方多粘菌素B软膏联合普济痔疮栓治疗肛窦炎的临床疗效.方法 选取2018年6月-2019年6月于重庆市中医院南桥寺院部门诊明确诊断为肛窦炎的患者60例,采用抓阄法随机分为治疗组和对照组,每组30例.治疗组予以复方多粘菌素B软膏联合普济痔疮栓治疗,对照组予以普济痔疮栓治疗,比较2组治疗前、治疗后3 d、7 d症... 相似文献