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51.
Nodular hyperplasia surrounding fibrolamellar carcinoma 总被引:2,自引:0,他引:2
We report a case of acetaminophen-induced liver necrosis in a 14-year-old girl. At autopsy, a 9 cm subcapsular nodule was present in the right lobe of the liver which showed distinct zonation: a central greyish white area of fibrolamellar carcinoma with a peripheral fleshy, tan-coloured rim ranging from 1 to 2 cm in thickness. This peripheral zone consisted of nodular, hyperplastic parenchyma resembling the changes seen in focal nodular hyperplasia, and stood out from the adjacent necrotic parenchyma. The sparing of this zone from the deleterious effects of acetaminophen provides indirect evidence of a predominantly arterial rather than portal blood supply to this region. The arterial supply was most probably derived from the tumour vasculature and may explain the parenchymal hyperplasia sometimes reported adjacent to a fibrolamellar carcinoma. Awareness of this phenomenon is essential when evaluating a needle biopsy, as sampling of this region may lead to a false negative diagnosis. 相似文献
52.
Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia 总被引:1,自引:0,他引:1
Muscle fiber typing and in vitro contracture tests were performed in 59 patients investigated for susceptibility to malignant hyperthermia (MH). Eighteen patients were found to be susceptible to MH. There was no difference in age or fiber type distribution between MH susceptible and non-susceptible patients. No correlation was found between age and fiber type distribution. Separate analyses for each diagnostic group revealed no relationship between age or fiber type distribution and response to halothane or caffeine. When all caffeine results were pooled, however, there was a significant effect of age on the caffeine specific concentration (the concentration eliciting a contracture of 1 g), but not on the caffeine threshold concentration (the minimal concentration eliciting an increase in tension). It is concluded that age and fiber type distribution have no influence on MH diagnosis, if the protocol of the European MH Group for evaluation of susceptibility to MH is followed. 相似文献
53.
本文对52例涎腺恶性肿瘤进行了回顾性研究。52例中发生于腮腺者27例(51.9%);病理类型以腺样囊性癌和粘液表皮样癌最多见;随访2~8年,死亡19例,病死率最高者为腺癌(5/8)和鳞癌(3/5)。作者对腺样囊性癌的病理分型提出了不同看法。 相似文献
54.
Ruprecht Nitschke Charles Pratt Michael Harris Jeffrey Krischer Teresa J. Vietti Holcombe Grier Willem Kamps Stuart Toledano 《Investigational new drugs》1992,10(2):93-96
CHIP (325 mg/M2), a second generation cisplatin derivative, was administered intravenously every 3 weeks to 85 pediatric patients with recurrent sarcomas (19), osteosarcomas (20), neuroblastoma (23), germ cell tumors (10), and other malignant tumors (7). Thirty-eight of them had been previously exposed to cisplatin. Partial remissions were only observed in 3 of 23 (13% SE=7%) patients having neuroblastoma. Severe thrombocytopenia (65%) and neutropenia (35%) were the dose limiting factors. 相似文献
55.
Thick malignant melanomas in general tend to have a poor prognosis, but exceptions occur where there may be no further recurrence. The reasons for this difference in clinical behaviour are not fully understood. We have looked at thick malignant melanomas (greater than 3.0 mm) in the East of Scotland that have no evidence of metastasis after a minimum of 6 years follow-up and compared the clinical and histological features with a similar group, associated with histological evidence of metastasis and/or death. Both groups received similar treatment regimes. We have identified 41 patients with thick melanomas in the former group. When compared with the control group, factors found to be significantly different between the two groups were: the nature of the lower margin of the tumour; vascular invasion; and anatomical location. 相似文献
56.
作者报告了该院30年来经手术及病理证实的15例胰腺囊性肿瘤,男5例,女10例,其中囊腺瘤3例,囊腺瘤恶变3例,囊朱癌9例,肿瘤位于胰尾部8例,体尾部6例,胰头部1例。2例有肝转移,1例肿瘤浸润胃后壁,根治生切除10例,单纯肿瘤切除、肿瘤切除加肝转移瘤局部切除、囊腺癌内外引流、肿瘤活检各1例。术后死亡1例。随访12例,10例效果满意,2例囊腺癌行内外引流者术后6、9个月死亡。文中讨论了胰腺囊性肿瘤的 相似文献
57.
对经手术和病理证实的83例膀胱肿瘤进行超声显像和膀胱镜检查的对比性分析。结果表明,膀胱镜对膀胱肿瘤的诊断符合率为97.5%,略高于超声显像符合率的95.2%;但对膀胱肿瘤的术前分期,膀胱镜检查尚存在局限性,而超声显像可弥补膀胱镜检查的不足。本文超声显像对膀胱肿瘤的术前分期准确率达89.5%。超声显像对小于0.5cm的小膀胱肿瘤之检出率不如膀胱镜高。因此在常规检查以及对肿瘤的术前分期时,应以超声显像作为首选,同时结合膀胱镜检查,可进一步提高膀胱肿瘤的术前诊断正确率。 相似文献
58.
P Peters F A Flachskampf S Hauptmann H B Lo C J Schuster 《European heart journal》1992,13(11):1585-1588
Cardiac malignant mesenchymoma is an extremely rare malignancy with poor prognosis. We report a patient presenting with a history and clinical findings typical of mitral stenosis. Transthoracic echocardiography showed a mass on the thickened posterior mitral leaflet. Transoesophageal echocardiography revealed two tumoural masses: one on the atrial side of the posterior mitral leaflet causing mitral obstruction, the other arising in the region of the right lower pulmonary vein orifice and obstructing inflow through this vein. 相似文献
59.
M.H. THERKILDSEN N. CHRISTENSEN L.J. ANDERSEN S. LARSEN M. KATHOLM 《Histopathology》1992,21(2):167-171
Malignant transformation of a benign Warthin's tumour (adenolymphoma) is extremely rare. The light microscopic and ultrastructural features of an adenocarcinoma arising in a Warthin's tumour in the parotid gland are described. Light microscopy demonstrated a transition zone from the benign to the malignant component, and the malignant cells revealed oncocytic features by both light- and electronmicroscopy. 相似文献
60.
We report a case of primary extrarenal Wilms' tumour which, on histological examination, revealed a zone of hyalinized blastema adjacent to, and within the tumour capsule. The tumour showed a predominant stromal component. The presence of the hyalinized blastema adjacent to the tumour raises the possibility that some cases of extrarenal Wilms' tumour may have a precursor lesion. 相似文献