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81.
Mark S. Wallace Steven G. Charapata Robert Fisher Michael Byas‐Smith Peter S. Staats Martha Mayo Dawn McGuire David Ellis 《Neuromodulation》2006,9(2):75-86
Objective. The safety and efficacy of intrathecal (IT) ziconotide was studied in a randomized, double‐blind, placebo‐controlled trial. Materials and Methods. Patients (169 ziconotide, 86 placebo) with severe chronic nonmalignant pain unresponsive to conventional therapy and a visual analog scale of pain intensity (VASPI score) ≥ 50 mm were treated over a 6‐day period in an inpatient hospital setting. Initial starting dose was 0.4 µg/hour and was titrated to analgesia or intolerance (maximum dose 7.0 µg/hour). The starting and maximum doses were reduced to 0.1 µg/hour and 2.4 µg/hour, respectively, due to adverse events (AEs). Results. The mean percent reduction in VASPI score from baseline was 31.2% and 6.0% for ziconotide‐ and placebo‐treated patients, respectively (p ≤ 0.001). During the initial titration phase, a significantly greater percentage of patients in the ziconotide group compared to the placebo group reported AEs, including abnormal gait, amblyopia, dizziness, nausea, nystagmus, pain, urinary retention, and vomiting. Conclusion. Ziconotide provided significant analgesia in patients for whom conventional therapy failed. However, there was a considerable incidence of ziconotide‐associated AEs due to the rapid titration and high doses administered. 相似文献
82.
目的探讨一对一责任助产加笑气吸入对分娩镇痛的疗效。
方法将576例产妇随机分为观察组和对照组.每组288例,两组均采用一对一责任助产及其他产科处理措施,观察组同时给予笑气吸入.观察两组的产痛程度、产程时间、分娩方式、笑气对新生儿的影响、产后出血及尿潴留等。
结果观察组无痛分娩率达95.8%.而对照组则为0(P〈0.01),观察组的产程时间短于对照组(P〈0.01)。
结论笑气吸入分娩镇痛产程时间短,对母婴均无不良影响,加一对一责任助产.是一种理想的分娩方法,值得产科临床推广使用。 相似文献
83.
经皮激光椎间盘减压术治疗椎间盘源性腰痛 总被引:1,自引:0,他引:1
目的探讨经皮激光椎间盘减压术(percutaneous laser disc decompression,PLDD)治疗椎间盘源性腰痛的疗效。方法2002年6月~2004年12月我院对36例椎间盘源性腰痛,采用英国DIOMED公司半导体激光仪,激光功率15W,每个激光脉冲持续1s,间隔1s,照射能量800~1200J。VAS评分评价治疗效果。结果手术时间15~60min,平均30min。32例出现“疼痛复制效应”。36例随访6~36个月,平均11个月,32例有效(术后VAS评分改善≥3分18例,≥分14例),4例无效,有效率88.9%(32/36)。结论PLDD治疗椎间盘源性腰痛安全、有效、微创。 相似文献
84.
Relationships Between Arousal-Related Moods and Episodic Tension-Type Headache: A Biopsychological Study 总被引:3,自引:0,他引:3
An exploratory study was conducted examining arousal-related moods and episodic tension-type headache. Twelve subjects meeting International Headache Society criteria for episodic tension-type headache and 12 headache-free controls recorded headache activity and mood eight times daily for 14 consecutive days. Moods were measured using the Activation-Deactivation Adjective Check List, a self-report list that subjectively represents general arousal along two dimensions of Tension and Energy. Headache subjects had higher Tension levels than controls even in the absence of pain, and greater variation in this dimension as well. Within the headache group, Tension during pain-free periods was significantly lower than when experiencing headache, and was correlated with headache activity. The results were taken to support Thayer's (1989) biopsychological model of mood and arousal, and are discussed in terms of the model's heuristic value for general arousal and headache research. 相似文献
85.
A new range of stand magnifiers has been released by the COIL company in the United Kingdom. Examination of these magnifiers reveals that they fail to deliver the rated magnifications labelled prominently on the appliances, as a result of the manufacturer's conformance with the requirements of the German DIN standard and the use of back vertex power (F'v) rather than equivalent dioptric power (Fm) of the magnifier. In this study we provide information on the optometric parameters of these new stand magnifiers that will assist the more accurate specification of improvements in vision expected from their use. 相似文献
86.
87.
Federigo Sicuteri Maria Nicolodi Bruno Marcello Fusco Salvatore Orlando 《Headache》1991,31(9):577-581
Following tooth pulp extirpation, some subjects suffer from persistent pain which affects edentate sites in absence of any local pathology. As regards this peculiar pain, called phantom tooth pain (PTP), what is puzzling is the fact there is a low prevalence of PTP in a very large population showing identical conditions of tooth pulp extirpation. The present investigation indicates that PTP mainly affects migraine (M) and cluster headache (CH) sufferers, whereas it does not affect subjects who have a negative personal and family history for idiopathic headache (IH). These results circumscribe the presence of PTP to a specific section of the population. The present results, besides indicating that PTP may be the result of a peculiar neuronal predisposition relating to IH pathogenesis, suggests some practical therapeutic hints. In fact, successful anti- M and anti-CH prophylactic treatment greatly improve PTP syndrome. 相似文献
88.
华玉芳 《兰州大学学报(医学版)》2002,28(1):37-38,18
目的 观察不同低浓度罗哌卡因(ropivacaine,Rop)低位硬膜外镇痛对运动神经的阻滞作用。探讨罗哌卡因低位硬膜外镇痛的最佳药物浓度。方法 随机选择我院67例下腹部择期手术患者,术后随机分为5个治疗组(A、B、C、D、E)和一个对照组(F),3h后硬膜外腔用药。前5组使用不同浓度罗哌卡因(A:0.1%;B:0.15%;C:0.2%;D:0.25%;E:0.3%),F组使用0.9%生理盐水。注药前后20分钟分别观察、记录以下项目:1.视觉模拟评分(Visual analogue scale,VAS);2.阻滞区运动神经反射;3. 下肢指令运动。结果 不同低浓度罗哌卡因均有程度不同的术后镇痛作用。对运动神经的阻滞作用A、B、C三组与对照组无显著性差异(P>0.05),而D、E两组有显著性差异(P<0.05)。结论 选择浓度为0.2%的罗哌卡因低位硬膜外镇痛既可以有效地发挥术后镇痛作用,又最大程度地减少了对运动神经的阻滞作用,有利患者术后恢复。 相似文献
89.
C. I. V. FRANKLIN 《Journal of Medical Imaging and Radiation Oncology》1991,35(1):68-71
The records of 108 adult patients with supratentorial low grade astrocytoma presenting between 1/1/80 and 31/12/87 were examined for the following factors which might affect survival: patient age, extent of surgical resection, site of tumour, tumour grade, radiation field size and radiation dose. Univariate analysis showed that patient age, field size and radiation dose were significant prognostic factors, but with multivariate analysis only patient age and radiation field size were significant independent variables. It is possible that field size is a proxy variable for tumour size. 相似文献