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Mimmi Tolvanen Jaakko Katainen Marja-Leena Mattila Satu Lahti 《Acta odontologica Scandinavica》2014,72(2):99-105
Objective. The aim was to determine if oral health-related behavior at the age of 11–12 years predicts adolescents' educational plans at the age of 15–16 years when adjusting for gender and parents' occupational level. Materials and methods. The study population consisted of all fifth and sixth graders starting in the 2001–2002 school year in Pori, Finland (n = 1691); of these, 1467 returned properly filled questionnaires on behavior (toothbrushing and consumptions of xylitol products, candies, soft drinks and sports drinks) in 2001 and on educational plans in 2005. Parents' occupational levels were reported in 2001 by one of the parents of 1352 of these children. Associations between adolescents' educational plans and their behavior, gender and parents' occupation were evaluated using logistic regression model. Results. Children's oral health-related behavior at age 11–12, gender and parent's occupational level predicted their educational plans at age 15–16. Association between educational plans and behavior, especially cumulative health behavior, remained statistically significant when controlling for gender and parent's occupation: OR = 1.4 for difference of one good habit, and OR = 5.3 for difference of five good habits. Conclusions. Since difference in oral health-related behavior can be seen already in primary school, even when controlling for parents' occupational level, polarization of adolescents may begin already in primary school stage or even earlier. 相似文献
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Women with polycystic ovary syndrome demonstrate worsening markers of cardiovascular risk over the short‐term despite declining hyperandrogenaemia: Results of a longitudinal study with community controls
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Abigail B. Shoben Kyle D. Rudser Scott S. Emerson 《Journal of biopharmaceutical statistics》2017,27(1):135-147
Statistical intuition suggests that increasing the total number of observations available for analysis should increase the precision with which parameters can be estimated. Such monotonic growth of statistical information is of particular importance when data are analyzed sequentially, such as in confirmatory clinical trials. However, monotonic information growth is not always guaranteed, even when using a valid, but inefficient estimator. In this article, we demonstrate the theoretical possibility of nonmonotonic information growth when using generalized estimating equations (GEE) to estimate a slope and provide intuition for why this possibility exists. We use theoretical and simulation-based results to characterize situations that may result in nonmonotonic information growth. Nonmonotonic information growth is most likely to occur when (1) accrual is fast relative to follow-up on each individual, (2) correlation among measurements from the same individual is high, and (3) measurements are becoming more variable further from randomization. In situations that may lead to nonmonotonic information growth, study designers should plan interim analyses to avoid situations most likely to result in nonmonotonic information growth. 相似文献
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Celeste A. Lemay RN MPH Carol Tobias MMHS Amarachi A. Umez‐Eronini BA MPH Carolyn Brown DDS Amanda McCluskey Jane E. Fox MPH Helene Bednarsh BS RDH MPH Howard J. Cabral PhD MPH 《Special care in dentistry》2013,33(2):70-77
Little is known about dental case managers as few programs have been scientifically evaluated. The goal of this study was to explore the impact of dental case manager on retention in dental care and completion of treatment plans, while specifically exploring the number of dental case manager encounters. Fourteen programs enrolled people with HIV/AIDS (PLWHA) in dental care and a longitudinal study between 2007 and 2009. The 758 participants had a total of 2715 encounters with a dental case manager over twelve months: 29% had a single encounter; 21% had two; 27% had 3–4 and; 23% had 5–29 encounters. Adjusting for baseline characteristics, participants receiving more encounters were significantly more likely to complete their Phase 1 treatment plan, be retained in dental care, and experience improvements in overall oral health status. Organizations considering efforts to improve the oral health of vulnerable, hard‐to‐engage populations should consider these findings when planning interventions. 相似文献
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《JACC: Cardiovascular Imaging》2019,12(9):1769-1779
ObjectivesThis study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR)-derived mitral annular plane systolic excursion (MAPSE) in a large multicenter population of patients with hypertension.BackgroundIn patients with hypertension, cardiac abnormalities are powerful predictors of adverse outcomes. Long-axis mitral annular movement plays a fundamental role in cardiac mechanics and is an early marker for a number of pathological processes. Given the adverse consequences of cardiac involvement in hypertension, the authors hypothesized that lateral MAPSE may provide incremental prognostic information in these patients.MethodsConsecutive patients with hypertension and a clinical indication for CMR at 4 U.S. medical centers were included in this study (n = 1,735). Lateral MAPSE was measured in the 4-chamber cine view. The primary endpoint was all-cause death. Cox proportional hazards regression modeling was used to examine the association between lateral MAPSE and death. The incremental prognostic value of lateral MAPSE was assessed in nested models.ResultsOver a median follow-up period of 5.1 years, 235 patients died. By Kaplan-Meier analysis, risk of death was significantly higher in patients with a lateral MAPSE < median (10 mm) (log-rank; p < 0.0001). Lateral MAPSE was associated with risk of death after adjustment for clinical and imaging risk factors (hazard ratio [HR]: 1.402-per-millimeter decrease; p < 0.001). Addition of lateral MAPSE in this model resulted in significant improvement in the C-statistic (0.735 to 0.815; p < 0.0001). Continuous net reclassification improvement was 0.739 (95% confidence interval: 0.601 to 0.902). Lateral MAPSE remained significantly associated with death even after adjustment for feature tracking global longitudinal strain (HR: 1.192-per-millimeter decrease; p < 0.001). Lateral MAPSE was independently associated with death among the subgroups of patients with preserved ejection fraction (HR = 1.339; p < 0.001) and in those without history of myocardial infarction (HR: 1.390; p < 0.001).ConclusionsCMR-derived lateral MAPSE is a powerful, independent predictor of mortality in patients with hypertension and a clinical indication for CMR, incremental to common clinical and CMR risk factors. These findings may suggest a role for CMR-derived lateral MAPSE in identifying hypertensive patients at highest risk of death. 相似文献
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