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排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
目的 探讨糖尿病肾病(DN)患者血清瞬时受体电位通道7(TRPM7)、沉默调节蛋白-1(Sirtuin-1)与钙磷代谢、颈动脉钙化的相关性。方法 选取2020年12月—2022年11月成都大学附属医院收治的97例DN患者作为DN组,另取同期在该院就诊的120例2型糖尿病患者作为对照组。采用实时荧光定量聚合酶链反应检测血清TRPM7的表达,酶联免疫吸附试验检测血清Sirtuin-1水平。采用Pearson法分析DN患者血清TRPM7、Sirtuin-1水平与钙磷代谢的相关性,并通过多因素Logistic逐步回归模型分析DN患者颈动脉钙化的危险因素。结果 DN组血肌酐、尿素氮、血清TRPM7、血磷、颈动脉钙化率高于对照组(P <0.05)。DN组Sirtuin-1、血钙低于对照组(P <0.05)。Pearson相关性分析结果显示,DN患者血清TRPM7与血钙呈负相关(r=-0.247,P=0.000),与血磷呈正相关(r=0.415,P=0.000);DN患者血清Sirtuin-1与血钙呈正相关(r=0.367,P=0.000),与血磷呈负相关(r=-0.505,P=0.00... 相似文献
72.
Jaana M Ward MM Paré G Wakefield DS 《International journal of medical informatics》2005,74(9):719-731
Despite the growing interest in adopting information technology (IT) in healthcare, the degree of technology sophistication varies among healthcare organizations. Changes in the health care sector and continuous pressure to improve the quality of care have driven the evolution of IT in hospitals. This paper provides an overview of clinical IT sophistication in a sample of U.S. hospitals, and compares clinical IT capacities in this sample with a sample of Canadian hospitals. The instrument used for the comparison measures three clinical dimensions of IT sophistication: functional sophistication, technological sophistication and integration level. Clinical areas that were considered include patient management, patient care activities and clinical support activities. The comparison between hospitals in Iowa and Canada shows differences in clinical IT sophistication between the two settings. Hospitals in Iowa appear to have more technologies but fewer computerized processes and integration of patient management activities. Technological sophistication however, was low in both samples. Our findings confirm the construct validity of the measurement instrument and show initial evidence of its generalizability. More initiatives using the instrument would lead to enhancement in IT assessment tools that can be used for evaluation of IT in relation to patient management and quality outcomes. 相似文献
73.
Bédard P Proteau L 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2001,138(4):419-431
Movement planning has been shown to be optimized when the participant is permitted to see his or her hand resting on the
starting base prior to movement initiation. However, this proposition is opposed by contradictory results. In the present
study, we wanted to determine whether these conflicting results were caused by procedural differences. The results showed
that seeing one's hand on the starting base did not result in more accurate aiming movement than when this information was
not available. However, lower aiming errors were found when one was asked to foveate the starting base and then the target
prior to movement initiation, but only when no dynamic visual information was available during movement. When an aiming movement
was performed while one's hand was visible in visual periphery, foveating the starting base or not prior to movement initiation
did not modify aiming accuracy. These results suggest that gazing at the starting base and then at the target provides an
eye-based representation of the movement to be performed that can be used by the CNS to plan a manual aiming movement. Information
for better planning of the direction – but not the extent – dimension of an upcoming movement can also be derived from dynamic
visual information available in peripheral vision.
Electronic Publication 相似文献
74.
Event-Related Potential Correlates of Two Stages of Information Processing in Physical and Semantic Discrimination Tasks 总被引:6,自引:1,他引:6
Event-related potentials were studied while subjects performed physical and semantic discrimination tasks. Two negative components, NA and N2, were observed in both kinds of discriminations. The earlier component, NA, had a constant onset latency, but its peak latency varied as a function of stimulus complexity. N2 latency varied in relation to changes in the peak of NA. RT and P3 followed N2 by similar amounts of time across tasks. The NA and N2 components were interpreted as reflecting partially overlapping sequential stages of processing associated with pattern recognition and stimulus classification, respectively. 相似文献
75.
76.
混合遗传算法在医学图像配准中的应用 总被引:2,自引:0,他引:2
针对遗传算法和梯度算法各自的优点和缺陷,提出了遗传算法和梯度算法相结合的松散耦合和紧密耦合两种混合遗传算法,并利用基于排挤的小生境技术对其性能进行了改进,使其在搜索能力和收敛速度上都有了较大提高。利用此算法成功实现了以互信息为相似性测度的医学图像配准。计算实例结果表明,本算法能够有效克服局部极值的影响,具备较强的抗噪能力,是一个精度高、稳定性好的医学图像配准算法。 相似文献
77.
Medium-resolution genotyping has the goal of distinguishing different subgroups instead of each element in a group. An oligonucleotide
array provides an inexpensive, high-throughput method to identify differences in DNA sequence among individuals, which is
fundamental for genotyping. As the cost and difficulty of designing and fabricating the oligonucleotide array dramatically
increase with the number of probes used, it is therefore important to have a design with a minimum number of probes meeting
the requirement of medium-resolution genotyping. The first algorithm for designing and selecting probes for oligonucleotide
array-based medium-resolution typing is reported. The goal in deriving the algorithm was to select a minimum number of probes
from a large probe set on the premise of minimum loss of resolution. The algorithm, which was based on entropy, conditional
entropy and mutual information theory, was used to select the minimum number of probes from a large probe set. The algorithm
was tested on a human leukocyte antigen (HLA) sequence data set. Thirty probes were selected from 390 probes for HLA-A, and
60 probes were selected from 767 probes for HLA-B. Although the number of probes was reduced by almost ten times, the distinguishability
was reduced only a little, by 0.45% (from 99.90% to 99.45%) for HLA-A and 0.27% (from 99.84% to 99.57%) for HLA-B, respectively.
This is a satisfactory and practical result. 相似文献
78.
Taoka M Toda T Iriki A Tanaka M Iwamura Y 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2000,134(2):139-146
Single-neuron activities were recorded in the hindlimb region of the primary somatosensory cortex and part of area 5 in awake Japanese monkeys. A total of 1050 units were isolated from five hemispheres of four animals. Receptive fields (RFs) and submodalities were identified for 90% of isolated neurons in areas 3a and 3b. The percentage decreased as the recoding site moved to the more caudal areas. Deep or skin submodality neurons were dominant in area 3a or area 3b, respectively. Deep submodality neurons increased in more caudal areas and were the majority in areas 2 and 5. These observations were consistent with those in the hand and/or digit or arm and/or trunk region. The identified neurons were classified by their RF positions into four types: the foot, leg, foot and leg, or hindlimb and other body parts type. Among 831 identified neurons, 33 neurons had bilateral RFs, 14 had ipsilateral RFs, and the rest (N=784) had contralateral RFs. The relative incidence of neurons with bilateral or ipsilateral RFs among identified neurons was less than 1% in areas 3a, 3b, and 1, and 16% or 25% in areas 2 or 5, respectively. Within areas 2 and 5, the percentage of neurons with bilateral or ipsilateral RFs was significantly smaller in the foot type (5%) than in other RF types (24-57%). RFs of the foot type were on the sole or single toe but never on multiple toes. These observations contrasted with the previous findings that neurons with bilateral RFs were more frequently seen in the hand and/or digit region and that RFs on multiple digit tips were dominant there. The present study thus demonstrated that neurons with bilateral RFs do exist in the hindlimb region. Similarly to the forelimb region, they were found mostly in areas 2 and 5, the caudalmost areas of the postcentral gyrus and hierarchically higher stages in information processing. The relative paucity of neurons with bilateral RFs on the foot, especially those with RFs on multiple toes, may reflect functional differences between the foot and the hand. 相似文献
79.
为探讨“军字1号”工程使用前后的病案首页质量变化,本文通过作者所在医院近八年病案首页的质量调查统计,对“军字1号”工程使用前后的病案首页质量作了详细的对照分析比较,为进一步加强“军字1号”工程中的病案首页质量管理提供经验。 相似文献
80.