Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanisms

A neuroexcitatory non-protein amino acid, β-N-oxalyl-l-α,β-diaminopropionic acid (β-ODAP), present in the seeds of the hardy legume crop grass pea (Lathyrus sativus L.), was considered responsible for human lathyrism. The levels of β-ODAP were reported to vary in different tissues during plant development, and to be affected by a wide range of environmental stresses. In this paper, dynamic changes in β-ODAP level at specific stages of plant development as well as the influences of various environmental factors, including nutrient deficiency, drought, salinity, toxic heavy metals, and Rhizobium symbiosis on β-ODAP levels were analyzed, highlighting the relationship between changes in β-ODAP concentrations and Rhizobium growth. Possible mechanisms underlying β-ODAP accumulation are proposed and future research is suggested.     

针刺太溪穴 丘墟穴的脑功能磁共振成像研究

目的通过脑功能磁共振成像了解针刺太溪穴、丘墟穴的脑功能区信号变化情况。方法收集12名健康志愿者,实验采用组块刺激模式(静息阶段与刺激阶段交替出现,重复3次,每个阶段持续60 s),按照随机配对数字表,分别手法捻转行针刺右侧太溪穴、丘墟穴(捻转角度180°,频率1.5 Hz),使用SPM2对扫描后图像进行后处理以观察激活图、激活区的差别。结果在校正像情况下(组分析,FWE,0.05,K≥10),针刺太溪穴主要激活右侧颞上回BA22,左侧额中回BA46,其次为左右顶叶中央后回BA2、BA3,左额叶额下回BA45。针刺丘墟穴主要激活左侧颞上回BA42、BA22,其次为右顶叶中央后回BA40、BA43,右额叶额下回BA47,右颞叶颞上回BA22和左侧脑岛BA13。结论针刺与认知相关的太溪穴、丘墟穴的脑部主要激活区域位于额颞顶叶,这些激活区功能与听觉及智能相关。     

肺癌误诊为肺结核的影像学分析

目的：探讨肺癌与肺结核的影像特征,分析总结误诊原因。方法：我院近年经手术、病理确诊为肺癌的误诊病例18例,年龄31~76岁,平均51岁,均有胸正侧位片及CT片,进行再读片。结果：18例中有9例误诊为浸润型肺结核,3例误诊为粟粒性结核,2例误诊为结核球,2例误诊为空洞型结核,1例误诊为干酪性肺炎,1例误诊为淋巴结结核。结论：误诊病例具有临床症状不典型、病灶部位、大小及形态不典型,其他影像表现等多样性的特点。对肺癌的影像特点认识不够、影像的多形性、复杂性及过分依赖某一征象,或合并症的诊断为造成误诊的主要原因。     

医学影像专业研究生培养的探讨

医学影像研究生的培养是造就现代医学影像学专业人才的重要途径之一。培养医学影像研究生的重点在于导师队伍建设和科室共同管理;医学影像基本功和影像诊断思维模式的训练;医学影像专业英语的学习;研究生创新能力和独立从事科研能力的培养;研究生科研表达能力的培养。     

胃间质瘤16层螺旋CT表现(附3例报道)

目的探讨16层螺旋CT多种后重组方法在诊断胃间质瘤中的应用价值。方法使用GE-lightspeed 16层螺旋CT机,对经手术、病理证实的胃间质瘤3例充气后行螺旋扫描,并行气体铸形,模拟管腔,立体剖面,仿真内镜及曲面重组,观察其病变特点。结果多层螺旋CT多种后重组方法在诊断胃间质瘤时,能从不同角度显示肿瘤的形态、大小、边缘及与邻近组织、器官的关系,表现为胃体部不规则形肿块,向腔内及腔外突,边界清楚,与周围组织、器官分界清晰。结论多层螺旋CT多种后重组方法对胃间质瘤的定位、定性诊断有很大价值。     

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

Microemulsion electrokinetic chromatography (MEEKC) offers a valuable tool for the rapid and highly productive determination of lipophilicity for metal-based anticancer agents. In this investigation, the MEEKC technique was applied for estimation of n-octanol-water partition coefficient (logP(oct)) of a series of antiproliferative complexes of gallium(III) and iron(III) with (4)N-substituted α-N-heterocyclic thiosemicarbazones. Analysis of relationships between the experimental logP(oct) and the retention factors of compounds showed their satisfactory consistency in the case of single metal sets, as well as for both metals. Since none of available calculation programs allows for evaluating the contribution of central metal ion into logP(oct) (i.e. ΔlogP(oct)) of complexes of different metals, this parameter was measured experimentally, by the standard 'shake-flask' method. Extension of the logP(oct) programs by adding ΔlogP(oct) data resulted in good lipophilicity predictions for the complexes of gallium(III) and iron(III) included in one regression set. Comparison of metal-thiosemicarbazonates under examination in terms of logP(oct) vs. antiproliferative activities (i.e. 50% inhibitory concentration in cancer cells) provided evidence that their cytotoxic potency is associated with the ability to cross the lipid bilayer of the cell-membrane via passive diffusion.     

腰椎间盘突出症腧穴热敏化红外客观显示研究

目的：通过红外成像技术探索热敏化腧穴客观显示的可能性。方法：采用TSI-21型热扫描成像技术,分别对纳入试验组60例腰椎间盘突出症患者和对照组60例非腰椎间盘突出症体检者,以穴区红外辐射强度及艾灸传热长径为观察指标,比较腰阳关、患侧大肠俞、患侧委中三个穴位的红外特征。结果：腰间盘突出症患者腰阳关、大肠俞、委中穴热敏化态时,其局部的红外辐射有其特征性改变,显示以高温特征为主;艾灸热敏化穴位的传热长径明显高于非热敏化穴位。结论：腰椎间盘突出症患者腧穴热敏化态在一定程度上能被红外成像客观显示,并非仅仅是受试者的主观感觉。     

具体性自传体记忆任务下抑郁症患者的功能磁共振成像特点

目的 探讨青年抑郁症患者在具体性自传体记忆任务下的功能磁共振成像(fMRI)特点.方法 利用西门子1.5T功能性磁共振成像系统,检测12例抑郁症患者和12名健康志愿者在具体性自传体记忆任务下的大脑激活情况.采用国际通用的SPM5软件在MATLAB 2007a上对两组被试的功能性磁共振原始图像数据进行预处理,再进行两样本t检验.结果 与正常对照组相比,抑郁症患者在具体性自传体记忆任务下激活程度减弱(P<0.01)的脑区包括左侧颞中回(BA 21)、壳核、右侧梭状回(BA 37)和枕叶楔叶(BA 18),而激活程度增强(P<0.01)的脑区为右侧顶叶上回(BA 7).结论 抑郁症患者在具体性自传体记忆任务下的大脑激活模式与正常个体存在明显差异,抑郁症患者可能存在提取具体性记忆事件的相关脑区功能受损.     

改进FCM算法在颅脑磁共振图像分割中的应用

模糊C均值（FCM）聚类算法广泛应用于医学图像分割中,但该算法在分割低信噪比图像时,会产生较大的偏差。为解决这一问题,本文提出一种改进的FCM算法,充分考虑相邻像素之间的影响,对FCM的目标函数做一定的修改。实验表明,该算法与FCM算法相比,既能有效分割图像,又对低信噪比图像具有很好的分割效果。