全文获取类型
收费全文 | 25861篇 |
免费 | 1935篇 |
国内免费 | 913篇 |
专业分类
耳鼻咽喉 | 127篇 |
儿科学 | 605篇 |
妇产科学 | 333篇 |
基础医学 | 2276篇 |
口腔科学 | 195篇 |
临床医学 | 2319篇 |
内科学 | 5534篇 |
皮肤病学 | 314篇 |
神经病学 | 779篇 |
特种医学 | 1559篇 |
外国民族医学 | 17篇 |
外科学 | 4890篇 |
综合类 | 3792篇 |
现状与发展 | 4篇 |
一般理论 | 1篇 |
预防医学 | 602篇 |
眼科学 | 113篇 |
药学 | 1692篇 |
12篇 | |
中国医学 | 846篇 |
肿瘤学 | 2699篇 |
出版年
2024年 | 41篇 |
2023年 | 399篇 |
2022年 | 670篇 |
2021年 | 931篇 |
2020年 | 899篇 |
2019年 | 840篇 |
2018年 | 851篇 |
2017年 | 879篇 |
2016年 | 956篇 |
2015年 | 917篇 |
2014年 | 1468篇 |
2013年 | 1539篇 |
2012年 | 1274篇 |
2011年 | 1416篇 |
2010年 | 1219篇 |
2009年 | 1350篇 |
2008年 | 1321篇 |
2007年 | 1365篇 |
2006年 | 1251篇 |
2005年 | 1102篇 |
2004年 | 915篇 |
2003年 | 827篇 |
2002年 | 701篇 |
2001年 | 589篇 |
2000年 | 498篇 |
1999年 | 410篇 |
1998年 | 421篇 |
1997年 | 391篇 |
1996年 | 404篇 |
1995年 | 323篇 |
1994年 | 311篇 |
1993年 | 245篇 |
1992年 | 232篇 |
1991年 | 247篇 |
1990年 | 181篇 |
1989年 | 172篇 |
1988年 | 148篇 |
1987年 | 111篇 |
1986年 | 100篇 |
1985年 | 143篇 |
1984年 | 98篇 |
1983年 | 64篇 |
1982年 | 80篇 |
1981年 | 73篇 |
1980年 | 74篇 |
1979年 | 63篇 |
1978年 | 46篇 |
1977年 | 53篇 |
1976年 | 28篇 |
1975年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
采用手术切除联合术后B超引导肝内门静脉区域化疗(简称PHPC)治疗胃肠道癌异时肝转移24例。随访4~54个月,结果:术后经3个疗程的PHPC,8例已存活肥18~48个月;13例分别经过2~11次的PHPC,已存活5~39p个月;另3例死亡。作者认为,对继发性肝癌采用手术切除配合术后B超引导的PHPC是一种延长患者生存期的有效联合治疗方案。 相似文献
52.
J. G. Boonstra Johan W. van der Pijl Yves F. C. Smets Herman H. P. J. Lemkes Jan Ringers Leendert A. van Es F. J. van der Woude Jan A. Bruijn 《Transplant international》1997,10(6):451-456
To examine the incidence of interstitial and vascular
rejection in pancreas allografts and its impact on graft survival, we studied 36 percutaneous pancreas biopsies and 10 pancreas
transplantectomy specimens from 32 patients who had undergone simultaneous pancreas-kidney transplantation. Interstitial rejection
(IR) was predominantly found in the biopsies, while vascular rejection (VR) was most prominent in the transplantectomies.
Pancreas graft survival was significantly decreased for pancreas grafts that had suffered from vascular rejection when compared
to those with only interstitial rejection. Potential rejection markers, i. e., serum amylase, glucose, creatinine, and urinary
amylase, did not correlate with histological signs of rejection, although increased levels of serum amylase were, in all but
one case, associated with rejection.We conclude that a percutaneous pancreas biopsy remains the most reliable method to determine
pancreas rejection, and that by distinguishing between IR andVR, a pancreas biopsy may provide important diagnostic as well
as prognostic information.
Received: 6 March 1997 Received after revision: 5 June 1997 Accepted: 30 June 1997 相似文献
53.
Abstract One hundred eighty-one consecutive patients with fulminant hepatic failure (FHF) presenting in a 2-year period were reviewed. In this cohort we examined the impact of pretransplant renal failure on mortality and morbidity following orthotopic liver transplantation (OLTx). Twenty-seven patients (18 female, 9 male) with a median age of 43.5 years (range 19–65 years) underwent OLTx. FHF was due to idiosyncratic drug reaction ( n = 4), paracetamol overdose ( n = 3), seronegative hepatitis ( n = 17), hepatitis B ( n = 1), veno-occlusive disease ( n = 1), and Wilson's disease ( n = 1). Renal failure was present in 14 patients, 7 of whom died (whereas there was 100 % survival in patients without renal failure). Pretransplant renal failure was associated with prolonged mechanical ventilation (13 days vs 6 days, P = 0.05), prolonged intensive care stay (17 days vs 8 days, P - 0.01) and prolonged hospital stay (27 vs 21 days, P = NS). Pretransplant renal failure did not predict renal dysfunction at 1 year after OLTx. We conclude that the survival of patients transplanted for FHF is inferior to that of patients transplanted for chronic liver disease (67 % vs 88 % 1-year survival in Birmingham). For patients with FHF undergoing transplantation, pretransplant renal failure strongly predicts poor outcome with significantly greater consumption of resources. 相似文献
54.
Lorenzo E. Derchi Carlo Martinoli Roberto Pontremoli Stefano Saffioti Caterina Pastorino 《European radiology》1993,3(2):186-189
Two patients with arteriovenous fistulas of the native kidney occurring after needle biopsy were evaluated using duplex and color Doppler ultrasonography. The first patient had a fistula with associated pseudoaneurysm: color Doppler showed the lesion as a small rounded area with whirling flow; spectral analysis allowed recognition of both the afferent artery with low impedance flow and the draining vein with pulsatile, arterialized flow. The second patient had a normal color Doppler study; however, spectral analysis demonstrated signals with low vascular impedance from an intra-parenchymal artery at the lower pole, and a jet of turbulent flow. Following disappearance of clinical findings, such Doppler abnormalities were no longer detectable. When a iatrogenic arteriovenous fistula is considered on clinical grounds, both color and Doppler spectral analysis of waveforms from intra-parenchymal vessels should be performed. Possibly, further advances in color Doppler technology will permit the use of this examination as the first imaging procedure in these clinical situations.Correspondence to: L. E. Derchi 相似文献
55.
Maite Sainz De La Maza Ramzy K. Hemady C. Stephen Foster 《Documenta ophthalmologica. Advances in ophthalmology》1993,83(1):33-41
While systemic autoimmune diseases are the main possibilities in the differential diagnosis of scleritis, other less common etiologies such as infections must also be considered. The authors report four cases of infectious scleritis to review predisposing factors, clinical characteristics, methods of diagnostic approach, and response to therapy. Two patients had primary scleritis and two patients had secondary scleritis following extension of primary corneal infection (corneoscleritis). Diagnoses included three local infections (one each withStaphylococcus. Acanthamoeba, and herpes simplex) and one systemic infection (Lyme disease). Stains, cultures, or immunologic studies from scleral, conjunctival, and/or corneal tissues, and serologic tests were used to make the diagnosis. Medical therapy, including antimicrobial agents, was instituted in all patients, and surgical procedures were additionally required in two patients (scleral grafting in one and two penetrating keratoplasties in another); the patient who required two penetrating keratoplasties had corneoscleritis and underwent eventual enucleation. Infectious agents should be considered in the differential diagnosis of scleritis. 相似文献
56.
应用原位杂交技术,观察了二乙基亚硝胺(DEN)诱发大鼠肝癌前病变组织中胎盘型谷胱甘肽S转移酶(GST-P)mRNA的表达。结果显示,GST-PmRNA主要在癌前病变肝组织中的变异灶及灶外卵圆形细胞内表达,且在变异灶间或和同一灶内阳性细胞间表达程度不尽一致,而正常肝、再生肝组织中未见其表达。提示在分子水平上变异灶细胞及卵圆型细胞可能成为实验性肝癌的癌前期细胞 相似文献
57.
Robert C Susil Kevin Camphausen Peter Choyke Elliot R McVeigh Gary S Gustafson Holly Ning Robert W Miller Ergin Atalar C Norman Coleman Cynthia Ménard 《Magnetic resonance in medicine》2004,52(3):683-687
A technique for transperineal high-dose-rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized prostate cancer), four MRI-guided transperineal prostate biopsies were obtained followed by placement of 14-15 hollow transperineal catheters for HDR brachytherapy. Mean needle-placement accuracy was 2.1 mm, 95% of needle-placement errors were less than 4.0 mm, and the maximum needle-placement error was 4.4 mm. In addition to guiding the placement of biopsy needles and brachytherapy catheters, MR images were also used for brachytherapy treatment planning and optimization. Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized. 相似文献
58.
E. Stermer J. Bejar† I. Miselevich† O. Goldstein D. Keren A. Lavy J. H. Boss† D. Keren 《Colorectal disease》2005,7(4):345-349
BACKGROUND: Total excision of colonic polyps is not always attainable and in some patients it is clinically contraindicated. Also, a resected polyp may be lost at any step between its endoscopic removal and its embedding in paraffin. The aim of this study was to compare the histological features of colonic polyps as analysed by the study of biopsy-forceps obtained samples with those assessed on scrutinizing the totally resected growths. PATIENTS AND METHODS: This prospective study included a cohort of 59 patients in whom, in the course of an elective colonoscopy, a total excision of a 6 mm-sized or larger polyp was called for. Sizeable biopsies were obtained by means of an Olympus Multibyte forceps prior to the total polypectomy. Subsequent to the study of the polypectomy specimens, the forceps biopsy samples were submitted for histological examination. The pathologists were blinded as to the source of the tissue they were studying. The diagnoses rendered by evaluating the biopsy samples and polypectomy specimens of each patient were contrasted with each other. RESULTS: Major discrepancies between the histological features of the fragments captured by the biopsy-forceps and the factual nature of the totally removed polyps were uncovered in 11 (18.6%) of 59 cases. Intriguingly, the grade of the tumours was underrated in all the 11 cases, as judged by contrasting the tentative diagnoses of the forceps-biopsies with the decisive diagnoses of the polypectomies. Importantly, 2 adenocarcinomas would have been missed by just looking at the forceps-retrieved sample. CONCLUSIONS: In our experience, a discordance of 18.6% is to be expected between the diagnoses rendered after examining forceps-biopsies of and totally excised colonic polyps. Nevertheless, it is advisable to procure biopsies prior to the excision of the growths, because on those occasions in which patients' growths cannot be removed or have not been retrieved for one reason or another, a small forceps-captured tissue sample correctly reflects the characteristics of the polyp in 81.4% of the cases. Finally, the biopsies may be discarded in the event that total removal was successful. 相似文献
59.
60.
生长激素、肝细胞生长因子和烟酰胺对人胎胰岛细胞的增殖作用 总被引:2,自引:0,他引:2
目的研究生长激素(GH),肝细胞生长因子(HGF)和烟酰胺(NIC)对体外培养的人胎胰岛细胞的增殖作用及其交互作用。方法采用La(2^7)正交设计法在体外培养的人胎胰岛细胞的各组中分别加入不同浓度及组合的GH,HGF和NIC,培养48h后,收集各孔细胞,DTZ染色,计数。结果GH,HGF和NIC均起主要作用,HGF和NIC的交互作用不可忽视,最佳的生长因子组合及适配浓度为GH(100ng/ml)HGF(25ng/ml)NIC(100mmol/L)。结论GH,HGF和NIC均能促进体外培养的胰岛细胞的增殖,且组合GH(100ng/ml)HGF(25ng/ml)NIC(100mmol/L)的作用最大。 相似文献