全文获取类型
收费全文 | 498篇 |
免费 | 18篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 21篇 |
基础医学 | 2篇 |
临床医学 | 20篇 |
内科学 | 116篇 |
皮肤病学 | 1篇 |
神经病学 | 11篇 |
外科学 | 341篇 |
综合类 | 12篇 |
现状与发展 | 1篇 |
预防医学 | 3篇 |
药学 | 2篇 |
出版年
2024年 | 2篇 |
2023年 | 5篇 |
2022年 | 4篇 |
2021年 | 11篇 |
2020年 | 17篇 |
2019年 | 7篇 |
2018年 | 14篇 |
2017年 | 7篇 |
2016年 | 9篇 |
2015年 | 18篇 |
2014年 | 18篇 |
2013年 | 35篇 |
2012年 | 10篇 |
2011年 | 19篇 |
2010年 | 15篇 |
2009年 | 22篇 |
2008年 | 40篇 |
2007年 | 45篇 |
2006年 | 33篇 |
2005年 | 23篇 |
2004年 | 26篇 |
2003年 | 28篇 |
2002年 | 22篇 |
2001年 | 11篇 |
2000年 | 13篇 |
1999年 | 9篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 11篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1986年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有535条查询结果,搜索用时 562 毫秒
81.
82.
Background: Several studies have shown that large hiatal hernias are associated with a high recurrence rate. Despite the problem of recurrence,
the technique of hiatal herniorrhaphy has not changed appreciably since its inception. In this 3-year study we have evaluated
laparoscopic hiatal hernia repair in individuals with a hernia defect greater than 8 cm in diameter.
Methods: A series of 35 patients with sliding or paraesophageal hiatal hernias was prospectively randomized to hiatal hernia repair
with (n= 17) or without (n= 18) polytetrafluoroethylene (PTFE). All patients had an endoscopic and radiographic diagnosis of large hiatal hernia. Both
repairs were performed by using interrupted stitches to approximate the crurae. In the group randomized to repair with prosthesis,
PTFE mesh with a 3-cm ``keyhole' was positioned around the gastroesophageal junction with the esophagus through the keyhole.
The PTFE was stapled to the diaphragm and crura with a hernia stapler.
Results: Patients were followed with EGD and esophagogram at 3 months postoperatively, and with esophagogram every 6 months thereafter.
Individuals with PTFE had a longer operation time, but the 2-day hospital stay was the same in both groups. The cost of the
repair was $1050 ± $135 more in the group with the prosthesis. There were two complications (1 pneumonia, 1 urinary retention)
in the group repaired with PTFE and one complication (pneumothorax) in the group without prosthesis. The group without PTFE
was notable for three (16.7%) recurrences within the first 6 months of surgery.
Conclusion: On the basis of these preliminary results it appears that repair with PTFE may confer an advantage, with lower rates of recurrence
in patients with large hiatal hernia defects.
Received: 1 May 1998/Accepted: 22 December 1998 相似文献
83.
Recurrent vomiting with failure to thrive is a common problem in neurologically impaired children. Many undergo fundoplication to control the underlying gastro-oesophageal reflux. The results of surgery are not always satisfactory and post-operative retching may be a major problem - a symptom indicative of activation of the emetic reflex. An animal model of antireflux surgery has been developed and used to investigate the effects of such surgery upon the emetic reflex and vagal influences on gastric motility. Following surgery, animals responded to a previously subemetic dose of a centrally acting opiate receptor agonist (loperamide), suggesting that fundoplication may sensitize the emetic reflex. A gastric vago-vagal reflex (tonic inhibition of corpus tone) and responses to direct stimulation of vagal motor efferents (both cholinergic and nonadrenergic noncholinergic responses) were not significantly affected by antireflux surgery. Mechanisms by which neural damage may sensitize the emetic reflex are discussed, together with the possible clinical implications for the management of post-operative symptoms in neurologically impaired children. 相似文献
84.
85.
目的 探讨腹腔镜食管裂孔疝修补术联合抗反流手术治疗胃食管反流病(GERD)合并食管裂孔疝的安全性和疗效。方法 回顾性分析2005年9月至2015年5月新疆维吾尔自治区人民医院收治的835例GERD合并食管裂孔疝病人的临床资料,均行腹腔镜食管裂孔疝修补术+胃底折叠术。结果 835例均成功完成腹腔镜食管裂孔疝修补术+胃底折叠术,无一例中转开放手术。其中联合其他手术183例(21.9%)。手术时间55.3(40~90)min;术中出血量20.4(5~50)mL,无术中术后输血者。术后24~48 h全流质饮食。术后随访3个月至10年,平均37.5个月。56例(6.7%)病人术后出现并发症,其中吞咽困难28例,食管裂孔疝复发(折叠的胃底疝入胸腔)4例,症状复发18例,胃肠胀气综合征6例。结论 腹腔镜食管裂孔疝修补术+胃底折叠术安全有效、创伤小、恢复快、并发症少,并可联合手术治疗其他疾病,是GERD合并食管裂孔疝病人的理想选择。 相似文献
86.
Antireflux surgery is an effective treatment for gastroesophageal reflux disease, but postoperation complications and durability may be problematic. The objective of the study was to determine whether inpatient antireflux surgery continued to decline in the United States due to concerns about its long‐term effectiveness and the popularity of gastric bypass surgery and to assess recent changes in its perioperative outcomes. Using the Nationwide Inpatient Sample, we identified adult patients undergoing inpatient antireflux surgery during 1993–2006 and compared the trends of inpatient antireflux surgery with inpatient gastric bypass surgery. Perioperative complications included laceration, splenectomy, transfusion, esophageal dilation, total parenteral nutrition, and infection. Inpatient antireflux surgery increased from 9173 in 1993 to 32 980 in 2000 (+260%) but then decreased to 19 668 in 2006 (?40%). Compared with 2000, patients undergoing inpatient antireflux surgery in 2006 were older (49.9 ± 32.4 vs. 54.6 ± 33.6 years) and had a longer length of stay (3.1 ± 10.0 vs. 3.7 ± 13.4 days), more complications (4.7% vs. 6.1%), and higher mortality (0.26% vs. 0.54%) (all P < 0.05). Compared with inpatient gastric bypass surgery, length of stay was longer and mortality was higher for inpatient antireflux surgery in 2006, but neither was significant controlling for age. In 2006, perioperative outcomes of inpatient antireflux surgery were better in high‐volume hospitals (all P < 0.01). Inpatient antireflux surgery continued to decline in the United States from 2000 to 2006, concomitant with a dramatic increase in inpatient gastric bypass surgery. Older patient age and worsening perioperative outcomes for inpatient antireflux surgery suggest increased medical complexity and possibly a larger share of reoperations over time. Designating centers of excellence for antireflux surgery based on local expertise may improve outcomes. 相似文献
87.
Ashraf A. Mohamed Khaled M. Mahran Mohamed M. Zaazou 《Saudi Journal Of Gastroenterology》2011,17(3):185-188
Background/Aim:
Laparoscopic fundoplication can alter the natural course of Barrett’s esophagus (BE). This study was undertaken to assess this role in patients with non-complicated BE.Materials and Methods:
From October 2004 to October 2009, 43 patients with BE (32 men and 11 women) underwent laparoscopic Nissen fundoplication surgery in the Department of Surgery at Minia University Hospital. The median age of these patients was 46 years (range: 22–68 years). Patients with high-grade dysplasia, invasive cancer, or previous antireflux surgery were excluded. All 43 patients had gastroesophageal reflux symptoms. Heartburn was present in all patients, regurgitation in 41 (95.3%), dysphagia in 8 (18.6%), retrosternal pain in 30 (69.8%), upper gastrointestinal hemorrhage in 6 (13.9%), and respiratory symptoms in 19 (44.2%). Nissen fundoplication was performed in all patients. Thirty-four patients (79.1%) had concomitant hiatal hernia and nine patients (20.9%) had low-grade dysplasia.Results:
The median follow-up period was 25.6 months. There was significant improvement of symptoms after surgery (P<0.05). Eight (18.6%) of those with short-segment BE had total regression and four (9.3%) of those with long-segment BE had a decrease in total length. Among the nine patients with preoperative low-grade dysplasia, dysplasia disappeared in seven, remained unchanged in one, and progressed to in situ adenocarcinoma in one patient.Conclusions:
laparoscopic fundoplication succeeded in controlling symptoms but had unpredictable effect on dysplasia and regression of BE. Laparoscopic fundoplication does not eliminate the risk of developing esophageal adenocarcinoma and therefore, endoscopic follow-up should be continued in these patients. 相似文献88.
目的 探讨腹腔镜下巨大食管裂孔疝应用补片修补和部分胃底折叠术的安全性及有效性。 方法 2006年8月至2009年4月中国人民解放军总医院普通外科对13例巨大食管裂孔疝病人行腹腔镜下裂孔疝补片修补,并同期行部分胃底折叠术。 结果 12例手术成功,1例伴有短食管,手术过程中因分离食管时出现食管损伤中转开胸治疗。手术时间90~180min,平均110min。 术中出血30~120mL,平均50mL,均未输血。12例术后症状完全缓解。术后住院时间3~30d,平均6d。术后随访3~25个月,平均12个月,未发现复发病例。 结论 对于巨大食管裂孔疝,腹腔镜下补片修补是一种安全有效的方法,具有创伤少,恢复快、副反应小的特点。 相似文献
89.
Revision of failed transoral incisionless fundoplication by subsequent laparoscopic Nissen fundoplication 总被引:2,自引:0,他引:2
AIM:To evaluate the feasibility and outcomes of laparoscopic Nissen fundoplication after failed transoral incisionless fundoplication(TIF).METHODS:TIF is a new endoscopic approach for treating gastroesophageal reflux disease(GERD).In cases of TIF failure,subsequent laparoscopic fundoplication may be required.All patients from 2010 to 2013 who had persistence and objective evidence of recurrent GERD after TIF underwent laparoscopic Nissen fundoplication.Primary outcome measures included operative time,blood loss,length of hospital stay and complications encountered.RESULTS:A total of 5 patients underwent revisional laparoscopic Nissen fundoplication(LNF)or gastrojejunostomy for recurrent GERD at a median interval of 24mo(range:16-34 mo)after TIF.Patients had recurrent reflux symptoms at an average of 1 mo following TIF(range:1-9 mo).Average operative time for revisionalsurgical intervention was 127 min(range:65-240 min)and all surgeries were performed with a minimal blood loss(<50 m L).There were no cases of gastric or esophageal perforation.Three patients had additional finding of a significant hiatal hernia that was fixed simultaneously.Median length of hospitalization was 2 d(range:1-3 d).All patients had resolution of symptoms at the last follow up.CONCLUSION:LNF is a feasible and safe option in a patient who has persistent GERD after a TIF.Previous TIF did not result in additional operative morbidity. 相似文献
90.
Nicholas Stylopoulos M.D. Cheryl J. Bunker M.D. David W. Rattner M.D. 《Journal of gastrointestinal surgery》2002,6(3):368-378
Dysphagia after laparoscopic Nissen fundoplication (LNF) is commonly attributed to edema and/or improperly constructed wraps,
and in some instances the cause can be difficult to identify. We report, for the first time, the development of secondary
achalasia after LNF as a cause of late-onset postoperative dysphagia. A total of 250 consecutive patients undergoing LNF were
analyzed for the development of postoperative dysphagia at a university hospital. Patients were considered to have secondary
achalasia if they met the following four criteria: (1) preoperative manometry demonstrating normal peristalsis and normal
lower esophageal sphincter (LES) relaxation; (2) lack of esophageal peristalsis on postoperative manometry or fluoroscopy
with or without incomplete LES relaxation; (3) no mucosal lesions seen on endoscopy; and (4) dysphagia refractory to dilatation.
The following three groups of patients were identified: patients who developed secondary achalasia (group A, n = 7); patients
with persistent dysphagia requiring and responding to postoperative dilatation (group B, n = 12 patients); and patients whose
postoperative recovery was not complicated by dysphagia (group C, n = 231). The groups were comparable in terms of all preoperative
variables except for age. Patients in group A were older than those in group B (57 years [range 27 to 66 years] vs. 36.5 years
[range 27 to 63 years], P = 0.028) but were not significantly older than patients in group C (45 years [range 20 to 84 years], P = 0.42). The onset of severe dysphagia was later in group Athan in group B (135 days [range 15 to 300 days] vs. 20 days [range
9 to 70 days],P = 0.002). The median weight loss in group A was also significantly greater than in Group B (15 pounds [range
11 to 44 pounds] vs. 4 pounds [range 0 to 15 pounds], P = 0.0007). Two patients in group A who underwent reoperation failed to improve. Botulinum toxin injections were tried in two
patients and Heller myotomy in one with good results. Nine patients in group B improved promptly after one dilatation, and
three improved after two dilatations. Secondary achalasia should be considered as one of the causes of persistent dysphagia
after an apparently successful antireflux operation. Secondary achalasia tends to occur in older patients and is characterized
by a delayed onset of symptoms. Imaging studies are a reliable means of excluding mechanical obstruction as a cause of secondary
achalasia, and a negative result should raise the suspicion of secondary achalasia. Esophageal motility studies are necessary
to confirm the diagnosis. Failure to consider the diagnosis of secondary achalasia can lead to multiple fruitless attempts
at dilatation or even inappropriate reoperations.
Presented at the Forty-Second Annual Meeting of The Society for Surgery of the Alimentary Tract, Atlanta, Georgia, May 20–23,
2001 (oral presentation). 相似文献