Development of a food composition database to study complementary feeding: An Italian experience

Food Composition Databases (FCDBs) are important tools for epidemiological research, public health nutrition and education, clinical practice and nutrition declaration on food labels. The aim of this paper is to describe the methodology used to compile a FCDB for the analysis on the dietary intake of an Italian cohort of infants, and to assess its strengths and weaknesses. Dietary data were collected using a 3-DD records compiled at 6, 9 and 12 months of age of the infants. We developed a FCDB that contains data from the Italian and the USDA food composition databases and other sources. Our FCDB includes 563 food derived from the analysis of 623 3-DD records. Non-commercial products are more consumed than commercial products (25.5% vs. 9.1% at 6 months, 58.4% vs. 18.1% at 9 months and 77.8% vs. 11.3% at 12 months) but the latter are the main source of missing data (>70% in each database, with the exception of the energy components), which is one of the major weaknesses of this tool. An integrated system of data collection (NUTRIRETE.lab) that brings together food composition data from public and private laboratories will allow us to build a more complete and representative food composition database.     

Contrasting associations of polymorphisms in FcγRIIa and DC-SIGN with the clinical presentation of dengue infection in a Mexican population

Dengue virus (DENV) causes a spectrum of illness from asymptomatic infection, to a mild febrile illness, to occasional more severe complications including hemorrhage and shock. Dengue is endemic in the state of Morelos, Mexico. Two single nucleotide polymorphisms (SNPs), rs1801274 of FcγRIIa and rs4804803 of DC-SIGN, have been associated with protection from or susceptibility to severe dengue infection. Both of these polymorphisms are located in genes for receptors with important roles in dengue pathogenesis, and their relationship with the clinical presentation of dengue infection in Mexican populations is unknown. In this study, real-time PCR was used to characterize the distribution of rs1801274 and rs4804803 in subjects with asymptomatic dengue infection (n = 145), uncomplicated dengue (n = 67), and severe dengue (n = 36) in Morelos. In contrast with previous studies, the histidine (A) variant of rs1801274 was associated with more mild infection: carrying the histidine allele (either homozygous or heterozygous) was associated with protection from symptomatic infection compared with asymptomatic (OR 0.51, p = 0.038). Histidine homozygotes were also less likely to present severe dengue (OR 0.34, p = 0.05). Logistic regression models confirm this association (OR 0.48, p = 0.04) and also indicate that the G allele of rs4804803 is associated with symptomatic dengue (OR 2.3, p = 0.08), after accounting for other biological factors including history of infection. This variant was rare in this study population, with a frequency of 5.4%. These findings reflect the complexity of influences on the development of severe dengue infection. The inclusion of asymptomatic infections and adjusted case definitions likely do not explain the entire disparity with previous findings. Interactions with other polymorphisms may explain why the association of rs1801274 is reversed in this population compared to others. This study demonstrates the importance of genetic association studies in multiple genetically distinct populations.     

创伤外科应用人性化护理的研究

目的 探讨人性化护理在创伤外科应用的效果.方法 转变服务观念,改变服务模式.结果 促进了医患关系和谐.结论 对创伤外科护理工作满意度提高.