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41.
【目的】分析糖尿病肾脏疾病(DKD)患者进展到终末期肾病(ESRD)的相关危险因素,筛查进展到ESRD的高风险人群,以早期预防。【方法】收集本院231例糖尿病肾脏疾病患者的临床资料,随访3年,据是否出现ESRD分为未进展到ESRD(133例)、ESRD组(98例)。使用分类树模型分析进展到ESRD相关危险因素,通过节点增益分析筛选进展到ESRD的高风险人群。【结果】从预测变量中筛选到4个重要解释变量:载脂蛋B(ApoB)、性别、糖尿病视网膜病变、收缩压;ApoB升高是DKD进展的重要的危险因素;ApoB>1.14mmol/L的慢性肾脏病(CKD)3~4期DKD患者,3年进展到ESRD的概率是75.0%,如合并糖尿病视网膜病变,有79.7%的概率进展到ESRD。【结论】分类树模型能有效筛选并分析进展到ESRD危险因素,并识别高风险人群特征,有利于早期防治。 相似文献
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目的 :探讨恶性肿瘤家族史与卵巢恶性肿瘤发病的关系。方法 :对 5 31例卵巢肿瘤患者的临床资料进行回顾性分析。结果 :良性卵巢肿瘤 4 35例 ,有恶性肿瘤家族史者 19例 ,占 4 37% ;恶性卵巢肿瘤 96例 ,有恶性肿瘤家族史者 11例 ,占 11 5 %。结论 :卵巢恶性肿瘤患者有恶性肿瘤家族史者发病率明显高于良性肿瘤患者 相似文献
43.
目的:建立超高效液相色谱串联三重四级杆质谱法(UPLC-TQ-MS)同时测定银杏叶中4个萜内酯成分的含量.方法:采用ACQUITYTM UPLC BEH C18(2.1 mm×100mm,1.7μm)色谱柱,以水(A)-甲醇(B)为流动相,等度洗脱(70%A),流速0.4 mL·min-1,柱温30℃;Waters XevoTM TQ质谱仪以多反应离子监测(MRM)方式进行负离子检测.结果:各成分在5.0 min内分离良好,在相应的浓度范围内与峰面积呈良好的线性关系,相关系数均>0.990 3;加样回收率(n=6)为98.83%~103.9%,RSD均小于3%.不同树龄果用银杏叶中萜内酯的含量差异较大,低树龄银杏叶含总内酯较高,随着树龄的增长,内酯含量逐渐降低.结论:该方法简便、快速、重复性好、专属性强,适用于银杏叶中萜内酯类成分的快速定量分析. 相似文献
44.
Shinpei Matsuda Taihiko Yamaguchi Saki Mikami Hitoshi Yoshimura Akihito Gotouda 《Medicine》2022,101(33)
The aim of this literature review was to summarize the clinical characteristics and symptoms of temporomandibular joint diseases, and to discuss the associations between temporomandibular joint diseases and categorization of malocclusion. Electronic literature searches were performed using the PubMed database. The authors established a differential diagnostic method for temporomandibular joint diseases related to malocclusion. A literature search using PubMed yielded 213 texts, of which based on exclusion criteria, 28 were included in this study. Malocclusions were categorized into 5 types. The authors suggested a diagnostic tree of temporomandibular joint diseases based on the types of malocclusion and 4 variables in clinical characteristics and symptoms. Clinicians treating malocclusions must attempt to clarify the cause of the occlusal condition. If caused by temporomandibular joint disease, it is important to make a proper differential diagnosis at first, and not to overlook the causative disease. Further clinical knowledge of associations between temporomandibular joint diseases and malocclusions should be accumulated, and the diagnostic tree should be improved based on new information. 相似文献
45.
胆管树干细胞(biliary tree stem cells,BTSCs)是一类存在于胆管壁上胆周腺内的干细胞,具有分化为成熟肝细胞、胆管上皮细胞及胰腺内分泌细胞等类型细胞的多向分化潜能,在肝损伤治疗、糖尿病救治等方面具有巨大应用前景.本文结合胆管及其相关组织的胚胎发育过程、解剖学特征、BTSCs谱系分布特点及分子标志... 相似文献
46.
Zaineb M. Alhakeem Yasir Mohammed Jebur Sadiq N. Henedy Hamza Imran Luís F. A. Bernardo Hussein M. Hussein 《Materials》2022,15(21)
A crucial factor in the efficient design of concrete sustainable buildings is the compressive strength (Cs) of eco-friendly concrete. In this work, a hybrid model of Gradient Boosting Regression Tree (GBRT) with grid search cross-validation (GridSearchCV) optimization technique was used to predict the compressive strength, which allowed us to increase the precision of the prediction models. In addition, to build the proposed models, 164 experiments on eco-friendly concrete compressive strength were gathered for previous researches. The dataset included the water/binder ratio (W/B), curing time (age), the recycled aggregate percentage from the total aggregate in the mixture (RA%), ground granulated blast-furnace slag (GGBFS) material percentage from the total binder used in the mixture (GGBFS%), and superplasticizer (kg). The root mean square error (RMSE) and coefficient of determination (R2) between the observed and forecast strengths were used to evaluate the accuracy of the predictive models. The obtained results indicated that—when compared to the default GBRT model—the GridSearchCV approach can capture more hyperparameters for the GBRT prediction model. Furthermore, the robustness and generalization of the GSC-GBRT model produced notable results, with RMSE and R2 values (for the testing phase) of 2.3214 and 0.9612, respectively. The outcomes proved that the suggested GSC-GBRT model is advantageous. Additionally, the significance and contribution of the input factors that affect the compressive strength were explained using the Shapley additive explanation (SHAP) approach. 相似文献
47.
Jihye Shin SeEun Choe Gyu-Nam Park Sok Song Ki-Sun Kim Byung-Hyun An Bang-Hun Hyun Dong-Jun An 《Viruses》2022,14(11)
Bovine coronavirus (BCoV) causes severe diarrhea in neonatal calves, winter dysentery in adult cattle, and respiratory disease in feedlot cattle, resulting in economic losses. A total of 16/140 calf diarrheic feces samples collected in South Korea between 2017 and 2018 were positive for BCoV. Phylogenetic analysis of the complete spike and hemagglutinin/esterase genes revealed that the 16 Korean BCoV strains belonged to group GIIa along with Korean strains isolated after 2000, whereas Korean BCoV strains isolated before 2000 belonged to group GI. Mice and goats inoculated with an inactivated KBR-1 strain (isolated from this study) generated higher antibody titers (96 ± 13.49 and 73 ± 13.49, respectively) when mixed with the Montanide01 adjuvant than when mixed with the Carbopol or IMS1313 adjuvants. Viral antigens were detected in the large intestine, jejunum, and ileum of calves inoculated with inactivated KBR-1 vaccine (104.0 TCID50/mL) at 14 days of post-challenge (DPC). However, no viral antigens were detected in calves vaccinated with a higher dose of inactivated KBR-1 strain (106.0 TCID50/mL) at 14 DPC, and they had high antibody titers and stable diarrhea scores. Currently, the group GIIa is prevalent in cows in South Korea, and although further research is needed in the future, the recently isolated KBR-1 strain has potential value as a new vaccine candidate. 相似文献
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