Tissue distribution of human calcium-binding protein (28 000 g mol-1)

Immunoreactive calcium-binding protein (28 000 g mol-1, L-CaBP) has been quantified using a specific radioimmunoassay to human cerebellar L-CaBP. The level of L-CaBP in post-mortem tissue samples varied from undetectable in muscle to 8 micrograms/mg-1 protein in the cerebellum and 16 micrograms mg-1 protein in the dentate nucleus. L-CaBP was found to be widely distributed throughout the nervous system while the only non-nervous tissue which contained appreciable levels was the renal cortex.     

Penetration of the Duodenum by an Ingested Needle with Migration to the Pancreas: Report of a Case

A case of a penetration of the duodenum by a needle with migration to the pancreas in a 50-year-old man is reported herein. The patient was referred to us with a chief complaint of diarrhea. An abdominal plain roentgenogram showed a needle in the upper abdominal area. An abdominal computed tomography scan and contrast X-ray revealed the foreign body to be located outside of the duodenum and in the head of the pancreas. An emergency operation was therefore performed on the first day and the needle in the head of the pancreas was thus extirpated safely. A perforation of the gastrointestinal tract by an ingested foreign body is difficult to accurately and quickly diagnose when no peritonitis or abscess formation is observed. Therefore, the use of contrast X-ray is considered to be useful in the diagnosis of such a perforation. Received: January 24, 2000 / Accepted: July 25, 2000     

Inhibition by CCK of ascending contraction elicited by mucosal stimulation in the duodenum of the rat

CCK released by intraluminal stimuli modifies duodenal activity contributing to a decrease in gastric emptying. However, the neural mechanisms by which CCK controls motility are not well known. The aim of this study was to investigate the interaction between CCK and the enteric nervous system through the study of the effects of CCK‐8 on ascending excitation. Anaesthetized Sprague‐Dawley rats were prepared with a strain‐gauge sutured to the duodenum wall. An electrode holder was placed in the duodenum lumen to elicit ascending contraction. Electrical field stimulation of the duodenal mucosa (4 Hz, 0.6 ms, 30 V) induced an ascending excitation which was blocked by hexamethonium (10 mg kg^–1; n=5) and atropine (0.3 mg kg^–1; n=5), but enlarged by L ‐NNA (10^–5 mol kg^–1; n=5). CCK‐8 (3 × 10^–9 mol kg^–1 10 min^–1) blocked ascending excitation and an inhibition of the induced phasic activity was observed instead (n=18). Individually, none of the CCK receptor antagonists (L‐364 718 and L‐365 260) (3 × 10^–7 mol kg^–1; n=6 each) blocked the inhibition of ascending excitation induced by CCK‐8. However, simultaneous infusion of both antagonists abolished CCK‐8 effect on electrical stimulation (n=5). Similarly, none of the CCK‐8 agonists (A‐71623, A‐71378, gastrin) modified the ascending excitation. In contrast, the simultaneous infusion of A‐71623 and CCK‐4 (n=4) induced an effect similar to CCK‐8. In conclusion, CCK‐8 blocked ascending contraction elicited by electrical field stimulation of duodenal mucosa by means of simultaneous activation of CCK‐A and CCK‐B receptors.     

Adenovirus Infection of the Duodenum in an AIDS Patient: An Ultrastructural Study

Intractable diarrhea in a 40-year-old woman with terminal acquired immunodeficiency syndrome resulted from adenovirus infection of the duodenal mucosa. Electron microscopic examination of a duodenal biopsy specimen performed because of clinical suspicion of cryptosporidiosis or microsporidiosis showed pathognomonic viral particles in the nuclei of mucosal epithelium. Extensive sloughing of damaged mucosal cells may have contributed to the diarrhea, for which no other cause was found during either pathologic or microbiologic analysis.     

新生儿十二指肠的观测

观测了30具新生儿(男18、女12)十二指肠的形态位置,主要结果如下;十二指肠起始部、66.67±8.61％位于T_(12)～L_1椎体之间,终止部、80.00±7.30％位于L_1～L_2椎体之间。十二指肠形状分四型,“C”形出现率占70.00±8.37％。十二指肠长为56.01±9.30mm,与身长之比值为1:9.02±1.25倍。十二指肠各部的长度、周径与腹膜关系及空肠曲的形态等也作了观测。     

右半结肠癌侵犯十二指肠的外科处理

在近１０年中对１０例右半结肠癌侵犯十二指肠者根据不同病理特点作了处理，术式包括十二指肠局部切除，穿孔修补、扩大胰十二指肠联合切除等，术后９例一期恢复，１例在处理并发症后也恢复出院。２例已生存３年以上，作者根据肿瘤浸润十二指肠程度，提出将浸润程度分为三型，Ｉ型，癌肿小范围浸润十二指肠，直径在１．５￣２ｃｍ以内，较活动；Ⅱ型，肿瘤浸润十二指肠直径大于２ｃｍ，受累部分比较固定，十二指肠周围组织可同时受累     

幽门螺杆菌感染与十二指肠胃上皮化生及胃泌素之间关系的研究

目的　通过对幽门螺杆菌 (Hp)感染与十二指肠胃上皮化生 (DGM )及胃泌素 (GAS)关系的研究 ,探讨Hp导致十二指肠溃疡 (DU)的发病机制。 方法　检测了 12 1例患者内镜、病理、Hp感染及DGM情况。同时测定了其中 6 6例患者的血清GAS浓度。结果　球部有溃疡者 ,胃及球部Hp检出率均显著高于球部无溃疡者 (P <0 .0 0 1) ;但球部Hp检出率在DU与CU、GU与CG之间无差别 (P >0 .0 5 ) ;球部有溃疡者DGM的检出率显著高于球部无溃疡者 (P <0 .0 0 1) ,且前者的DGM程度更重 (P <0 .0 0 1) ,但在DU与CU、GU与CG之间无差别 (P >0 .0 5 ) ;胃部Hp阳性者DGM的发生率 (73.0 % )显著高于胃部Hp阴性者 (37.5 % ,P <0 .0 0 1) ,DGM( )及以上者在Hp阳性组发生率 (47.2 % )也高于Hp阴性组 (2 1.9% ,P <0 .0 5 ) ;Hp阳性者血清GAS浓度显著高于Hp阴性者 (P <0 .0 1) ,但血清GAS浓度在Hp阳性的DU、CU、GU与CG之间无差别(P >0 .0 5 ) ;有DGM者血清GAS浓度也显著高于无DGM者 (P <0 .0 1) ,且随着DGM程度的加重 ,血清GAS浓度早递增趋势 ,两者呈正相关 (rs=0 .4 2 ,P <0 .0 1)。结论　Hp感染特别是十二指肠Hp定植及DGM是影响DU发生、发展的两大危险因素。Hp可影响DGM的发生与发展 ,其中部分可能通过增加血清GAS分泌的作用。