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991.
Zusammenfassung. Der Hundebandwurm, Echinococcus, kann in seinem Larvenstadium alle Teile des menschlichen K?rpers, zumeist die Leber, als
Zwischenwirt befallen. Der prim?re Knochenbefall ist mit weniger als 2 % aller Echinococcusl?sionen sehr selten. Wir berichten
über einen Fall eines ausgedehnten linksseitigen Becken- und Femurbefalls. Die Destruktion des Hüftgelenks, des Os pubis sowie
der ausgedehnte Befall des Os ileum und des proximalen Femurs machten eine Hüftgelenk- und Beckenteilresektion sowie den prothetischen
Ersatz notwendig. Ein Rezidiv im Bereich der linken Leiste nach 5 Jahren, ausgehend vom proximalen Femur, wurde mit erneuter
Resektion und Hüftprothesenwechsel behandelt. Der prim?r eingebrachte Polyacetal-Beckenersatz mu?te dabei wegen Instabilit?t
ebenfalls ausgetauscht werden. Ein sonderangefertigter CAD-Beckenersatz (CAD = „computer-aided designed“) wurde implantiert.
Additiv wurde eine Chemotherapie mit Mebendazol durchgeführt. Die Radikalit?t der Resektion beim oss?ren Echinococcusbefall
wird diskutiert.
相似文献
992.
Summary. The so-called extended diagnostic laparoscopy (EDL) facilitates the comprehensive exploration of the abdominal cavity, thus
improving the precision of the pretherapeutic tumor staging in gastrointestinal malignancies. EDL comprises visual inspection
with a specific preparation of all relevant sites, laparoscopic sonography and retrieval of samples for biopsy and cytology.
Additional relevant therapeutic information was obtained through EDL in 40.5 % of gastric cancer patients. EDL could be of
similar importance for diagnosing esophageal, hepatobiliary and pancreatic malignancies.
相似文献
993.
994.
Chest Wall Implants: Their Use for Pectus Excavatum,Pectoralis Muscle Tears,Poland's Syndrome,and Muscular Insufficiency 总被引:3,自引:3,他引:0
Darryl J. Hodgkinson 《Aesthetic plastic surgery》1997,21(1):7-15
Solid customized and prefabricated silicone implants have been used by the author for 15 years in a wide range of chest wall
deformities. Chest wall implants are often used in males seeking to augment a muscularly deficient or underdeveloped chest;
however, their greatest use has come in a variety of deformities both congenital and acquired, such as pectus excavatum, Poland's
Syndrome, and pectoralis muscle tears. The implants can be either customized using a moulage technique or are prefabricated,
manufactured implants which can be modified on the operating table to repair the contour deformity. The immediate postoperative
problem of seroma and subcutaneous implant ``show' has been minimized by careful planning, gentle technique, deep insertion,
improved patient positioning on the operating room table, and the use of oral anti-inflammatory medications. The long-term
results of these implants seem very satisfactory. The patients are usualy physically active, and the implants show no long-term
sequelae such as seroma, infection, displacement, or rupture. 相似文献
995.
Carlotta Castagnoli Claudia Trombotto Sabzima Ondei Maurizio Stella Maurizio Calcagni Gilberto Magliacani Simone Teich Alasia 《Burns : journal of the International Society for Burn Injuries》1997,23(7-8):565-572
In this study, skin-infiltrating cells were characterized in both the active and remission phases of post-burn hypertrophic scar biopstes. Immunohistochemistry examination of active phase samples showed an abundant presence of Langerhans cells, T cells, macrophages, a low presence of natural killer cells and the lack of B lymphocytes. In active hypertrophic scars T lymphocytes infiltrate deep into the superficial dermis and are also observed in the epidermis: CD3+ cells were present at about 222±107 per 0.25 mm2. In particular the analysis of lymphocyte subpopulations showed that CD4+ T cells predominate in the dermis as well as in the epidermis of active hypertrophic scars whereas CD8+ cells were less well represented (CD4/CD8 ratio is 2.06). This distribution was also shown in remission phase samples and in normotrophic scar specimens, although the lymphocyte number was significantly lower. Approximately 70 per cent of T lymphocytes present in the tissue involved in active phase hypertrophic scar samples were activated (positive with anti-HLA-DR and IL-2 receptor antibodies) which is significantly higher than remission phase hypertrophic and normotrophic scars, in which positivity was 40 and 38 per cent, respectively. Upon activation, the lesional lymphocytes release several cytokines, locally and transiently, that interact with specific receptors in response to different stimulation. Central to the immune hypothesis of hypertrophic scars is that some of the T-cell lymphokines act on keratinocytes, fibroblasts and other cell types to induce changes characteristic of these scars. The presence and close proximity of activated T lymphocytes and antigen-presenting cells of various phenotypes in both the epidermis and dermis of hypertrophic tissues provides strong circumstantial evidence of a local immune response. However, the manner in which T cells achieve and maintain their activated state in hypertrophic tissues in not yet known, and both antigen-dependent and independent mechanisms may contribute. 相似文献
996.
Claude Lassus 《Aesthetic plastic surgery》1997,21(1):25-31
During the past 20 years, numerous techniques have been described to improve the results of facelifting as well as the duration
of its rejuvenating effect. These increasingly aggressive techniques have increased the operating time, the potential morbidity
of the operation, and the duration of convalescence. No one can ensure that this evolution in sophistication of rhytidectomy
techniques give longer lasting results. Therefore, a simple technique applied under the appropriate indications gives good
and predictable results. 相似文献
997.
Agents for prevention or treatment of osteoporosis must now be tested in a large animal species that exhibits bone remodeling.
Ovariectomized, nonhuman primates provide one such model, and they consistently develop osteopenia accompanied by high bone
turnover rates. The goal of this study was to further characterize this model, and particularly to determine the effect of
ovariectomy on bone strength in vertebrae and femoral necks. Longitudinal evaluations of spinal bone mass and serum markers
of bone turnover were performed in 19 sham-ovariectomized (SHAM) and 18 ovariectomized (OVX), domestically reared cynomolgus
monkeys, aged >9 years. OVX monkeys lost bone relative to both baseline values and SHAM controls. Serum markers of bone turnover
were increased by OVX. After 72 weeks, both vertebral bone compressive strength and femoral neck breaking strength were significantly
decreased in OVX animals compared with SHAM. Ovariectomized cynomolgus monkeys, like postmenopausal women, develop accelerated
bone loss, increased bone turnover, and reduced bone strength, and provide a suitable large animal model for efficacy studies
with agents for prevention or treatment of osteoporosis.
Received: 24 June 1996 / Accepted: 3 September 1996 相似文献
998.
I. Gorai Y. Taguchi O. Chaki M. Nakayama H. Minaguchi 《Calcified tissue international》1997,60(4):317-322
Urinary excretion of cross-linked N-telopeptide of type I collagen (NTx) has been reported to be a specific marker of bone
resorption [18]. We assessed a new immunoassay for NTx as an indicator of changes in bone resorption caused by spontaneous
menopause and compared cross-sectionally the levels of urinary NTx, hydroxylysylpyridinoline (HP), lysylpyridinoline (LP),
hydroxyproline (OH-Pr), other serum biochemical indices, and lumbar spine and proximal femur bone mineral density (BMD). Eighty-one
Japanese women aged 22–77 participated in this study; 36 were premenopausal and 45 were postmenopausal. Urinary HP, LP, and
NTx stayed at low levels in the premenopausal period and rose 21%, 30%, and 67% in the postmenopausal period, respectively.
The rise in LP and NTx was statistically significant (P < 0.01), suggesting that NTx is mostly released from bone matrix when bone resorption is accelerated. When premenopausal
women were divided into two age groups and postmenopausal women were divided into two groups according to years since menopause
(YSM) there were significant differences in LP and NTx between women <4 YSM and women aged <40 and those women aged 41+ (P < 0.01 and P < 0.05, respectively). A significant 110% increase in urinary NTx and a 48% increase in urinary LP were observed in postmenopausal
women compared with age-matched premenopausal women aged 45–55. All biochemical markers other than serum PTH correlated significantly
with each other (r = 0.243–0.858, P < 0.05–0.0001). Urinary NTx inversely correlated with lumbar spine BMD. When postmenopausal women were divided into three
groups, the correlation between bone resorption and formation markers in women 0-1 YSM was greater than in women 2–10 YSM
and in women 11 + YSM, indicating that resorption and formation are coupled at the early postmenopausal period. We conclude
that urinary NTx is responsive to changes in bone metabolism caused by estrogen deficiency and may be a more sensitive and
specific marker than HP, LP, or OH-Pr in the early postmenopausal years.
Received: 15 February 1995 / Accepted: 18 October 1996 相似文献
999.
Amir Kurtaran Josef Pfreitfellner Peter Schaffarich Peter Smith-Jones Bruno Niederle Markus Raderer Irene Virgolini Helmar Bergmann Ernst Havlik 《European journal of nuclear medicine and molecular imaging》1997,24(10):1298-1300
The purpose of this study was to estimate the radiation doses to nursing staff, other patients, accompanying persons and family
members deriving from patients undergoing 111In-DTPA-d-Phe-1-octreotide (111In-OCT) scintigraphy. Dose rates were measured from 16 patients who had received an intravenous injection of 140±40 MBq 111In-OCT. The measurements were performed at three different distances (0.5, 1 and 2 m) at 10–20 min, 5–7 h and 24 h (and in
some cases, up to 48 h) after administration of 111In-OCT. The effective half-lives of the biexponential decrease of the dose rates were estimated to be 2.94±0.27 h (T
1) and 65.17±0.58 h (T
2). The calculated maximum dose to other persons in the waiting area was 27.2 μSv, to family members 61.5 μSv, to nursing staff
in a ward 24.1 μSv and to neighbouring patients in the ward 69.5 μSv. Our results clearly demonstrate that the calculated
maximum radiation exposure to accompanying persons, personnel, family members and other patients is well below the maximum
annual dose limit for non-professionally exposed persons.
Received 20 May and in revised form 9 July 1997 相似文献
1000.
96名镍作业工人测定结果:非特异酯酶阳性细胞百分率(ANAE+%)为76.8%±8.0%,T细胞亚群CD2、CD4、CD8阳性细胞百分率(CD+2%、CD+4%、CD+8%)及CD+4/CD+8比值分别为65.6%±10.5%、56.3%±12.1%、34.3%±8.2%和1.76±0.6;酵母多糖刺激的外周血多形核白细胞化学发光(PMN-CL)本底和峰值分别为48±23和3073±684CPS/106PMN;血清硒和丙二醛含量分别为1.22±0.23和4.76±0.88μmol/L。与非镍作业的地区对照组比较,T细胞CD+8%增高,CD+4/CD+8比值下降,化学发光的本底值降低,峰值增加,血清Se含量下降,丙二醛含量升高。分析镍作业工人工龄与后三项指标变化的关系,工龄大于20年与小于10年有统计学上明显差别。这些观察指标为镍作业人员医学观察增加新的监护指标提供依据。 相似文献