Effect of topical immunotherapy with squaric acid dibutylester for alopecia areata in Japanese patients

BackgroundThe Japanese guidelines for the treatment of alopecia areata list topical immunotherapies as a drug therapy for this condition. However, there is insufficient evidence of its efficacy to support this recommendation. Thus, we sought to clarify the effect of topical immunotherapy on the progression and severity of alopecia areata in Japanese patients.MethodsTo evaluate the effect of topical immunotherapy with squaric acid dibutylester (SADBE) in alopecia areata patients, we performed a retrospective cohort study on 49 alopecia patients who had received topical immunotherapy with SADBE. Patients were evaluated by the change in alopecia severity at 6 and 12 months after the initiation of topical immunotherapy. The improvement rate was calculated by determination of the complete and partial responses rate to treatment with topical immunotherapy by application of SADBE.ResultsThe improvement rate in all alopecia patients treated with SADBE topical immunotherapy was 57.8% (complete response; 11.1% and partial response; 46.7%).ConclusionsTopical immunotherapy with SADBE is an effective treatment for alopecia areata. Therefore, the current treatment recommendations for alopecia areata with topical immunotherapies are appropriate.     

Necrotising dermatitis in refractory acute myeloid leukaemia

Severe cutaneous infections in leukaemic patients are difficult to treat and can rapidly become fatal. We report on a case of essential thrombocythemia evolved to a myelodysplastic syndrome and finally, to an overt myeloid leukaemia, refractory to chemotherapy. In the presence of a marked neutropenia, the patients developed a wide Staphylococcus epidermidis necrotising dermatitis. The diagnosis was made possible only by a skin biopsy culture and the antibiotic treatment, based on antimicrobial susceptibility tests, rapidly resolved the infection. In neutropenic patients, appropriate laboratory tests and treatment, can lead to recovery of life-threatening infections.     

龙血竭胶囊加紫草油治疗放射性皮炎的临床疗效观察

目的 观察龙血竭胶囊加紫草油治疗放射性皮炎的临床疗效.方法 将72例已发生1级放射性皮炎患者随机分为2组,观察组患者36例用龙血竭胶囊加紫草油调成糊状药膏外涂皮肤反应区,并保持局部清洁,干燥,每天4次.对照组患者36例,采用一般护理方式进行临床护理,比较2组患者的临床疗效,并采用满意度测评量表评估患者的护理满意度.结果 观察组患者的治疗有效率为94.44％,对照组患者的治疗有效率为69.44％,观察组未发生3级以上放射性皮肤损伤,对照组11例患者发生3级以上放射性皮肤损伤.当放疗剂量＜ 60 Gy时,观察组放射性皮肤损伤程度显著低于对照组.2组比较存在明显差异,差异具有统计学意义（P＜0.05）;经满意度评估,观察组患者的护理满意度为100％,对照组为77.78％,2组比较差异明显,差异具有统计学意义（P＜0.05）.结论 采用龙血竭胶囊加紫草油对放射性皮炎有较好的疗效,方便、实用、安全.     

复方甘草酸苷联合盐酸非索非那定治疗淤积性皮炎的疗效观察

目的 观察静点复方甘草酸苷注射液（萘普芬注射液）联合盐酸非索非那定治疗淤积性皮炎疗效和安全性.方法 将入选的85例淤积性皮炎患者随机分为两组,对照组40例给予氯雷他定片复方丹参片及复方氟米松软膏治疗,治疗组给予静点复方甘草酸苷注射液联合盐酸非索非那定片及外用复方氟米松软膏治疗,治疗4周后评价临床疗效.结果 治疗组痊愈率40％,有效率91％,对照组分别为15％和67％,差异均有统计学意义（P＜0.05）,且治疗期间均未发生不良反应.结论 静点复方甘草酸苷注射液、口服非索非那定片治疗淤积性皮炎疗效好且安全.     

外用胰岛素治疗血糖偏高患者放射性皮炎的疗效分析

目的:探讨外用胰岛素治疗高血糖放射性皮炎的临床效果。方法:将42例高血糖放射性皮炎患者随机分为试验组与对照组,每组21例,两组患者均予以放射性皮炎常规治疗及护理,试验组在此基础上加用外用胰岛素,观察两组患者创面愈合情况,并做比较分析。结果:两组患者显效率比较差异有统计学意义(P<0.05)。结论:外用胰岛素治疗高血糖放射性效果较好,值得进一步推广。     

皮敏消胶囊治疗脂溢性皮炎92例临床观察

目的:评价皮敏消胶囊治疗脂溢性皮炎的临床疗效和安全性。方法:92例脂溢性皮炎患者分为治疗组和对照组各46例,治疗组患者口服皮敏消胶囊,3次/d,4片/次,外用复方吲哚美辛酊,2次/d,连续治疗2周为1个疗程;对照组患者口服氯雷他定片,1次/d,10 mg/次,外用复方吲哚美辛酊,2次/d,连续治疗2周为1个疗程。结果:治疗组患者治疗后痊愈率为67.39%,有效率为89.13%;对照组患者治疗后痊愈率为52.17%,有效率为71.74%。治疗组与对照组疗效比较,差异有统计学意义(χ2=4.420 4,P=0.035 5<0.05)。结论:皮敏消胶囊治疗脂溢性皮炎是安全的、有效的。     

面部激素依赖性皮炎患者的综合治疗

目的：了解面部激素依赖性皮炎患者的生活质量,观察综合治疗的临床疗效。方法将面部激素依赖性皮炎患者160例随机分为治疗组（外用吡美莫司乳膏）和对照组（外用赋形剂）,4周为1个疗程。治疗前后分别对2组患者进行皮肤病学生活质量指数（DLQI）问卷调查。结果治疗组总有效率79.7%,明显优于对照组的43.8%,同时治疗组患者DLQI改善更为显著。结论外用吡美莫司乳膏治疗面部激素依赖性皮炎可明显改善患者的生活质量,具有疗效好、副作用小等优点。     

Participants' Satisfaction with the Atopic Dermatitis Education Program: Assessing the Impact of Each Content Using Structural Equation Modeling

BackgroundOnly a few studies have tried to assess factors relevant to the satisfaction of the participants in atopic dermatitis (AD) educational programs. More systematic modeling of this issue is needed.ObjectiveTo examine the benefit of a conjoint educational program for AD on patients and caregivers in a clinical setting.MethodsIn a half-day educational program called “AD school”, 831 people (493 patients and 338 family members) participated for 8 years. Various educational and entertaining programs were provided. The on-site survey was administered to measure participants'' satisfaction and perception of the benefit. We applied structural equation modeling to identify the relations among satisfaction and perception.ResultsA total of 209 family survey data was obtained and analyzed. The survey items were grouped into four categories. The categories were classified as individual education, group education, fun activity, and overall satisfaction (fun, benefit, intention to re-join and recommend to others). According to the model that we built, comprehensive group education was demonstrated to be the most relevant factor affecting overall satisfaction.ConclusionOur holistic approach would allow dermatologists to improve the efficacy of the conjoint educational program for AD.