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991.
Robert J. Biersner Ph.D. William B. McHugh M.D. Ph.D. Richard H. Rahe M.D. 《Behavioral medicine (Washington, D.C.)》2013,39(3):12-17
Abstract Using 13 members of an amateur softball team during the last seven games of the regular season, associations were determined between overall offensive and defensive performance and levels of serum uric acid (SUA) and cholesterol, and urinary adrenaline and noradrenaline. Skilled players were found to have significantly lower cholesterol and noradrenaline levels than less skilled players whether the games were won or lost. Adrenaline and SUA levels did not differ between the two groups nor between losing or winning outcomes. The elevated cholesterol and noradrenaline levels found among the less skilled players may indicate that although they were stressed by the discrepancy between their expectations and their performance, they nonetheless maintained perceived control over performance because of the social support and reinforcement received from the other players and the coach. 相似文献
992.
Dr. John W. Mason M.D. 《Behavioral medicine (Washington, D.C.)》2013,39(1):6-12
Abstract An analysis is presented of selected aspects of stress theory and research in biology and medicine, both before and after the introduction of Selye's stress formulations, which have been of major importance in the development and popularity of this research area. An attempt is made to explore some possible sources of present confusion and controversy in the stress field, with a view to the development of new research strategies that may enable us to clarify, update, and revise stress concepts and to facilitate future progress. In particular, it is suggested that an experimental reevaluation of the concept of the nonspecificity of pituitary-adrenal cortical response is a matter of particular strategic importance, if we are to move out of the present prolonged period of stalemate and confusion over stress theory and terminology. Recent experimental studies which suggest that the nonspecificity concept may have been applied erroneously to lower level physiological mechanisms, rather than to higher level psychological processes, are reviewed. The possible implications of this development are discussed in terms of clarifying current concepts and providing guidelines for future lines of approach in stress research. 相似文献
993.
Amparo Castillo-Richmond MD Charles N. Alexander PhD Hector Myers PhD Vidya Kaushik MD Cesar Aranguri MD 《Behavioral medicine (Washington, D.C.)》2013,39(2):83-95
Abstract African Americans experience higher morbidity and mortality than Whites do as a result of hypertension and associated cardiovascular disease. Chronic psychosocial stress has been considered an important contributing factor to these high rates. The authors describe the rationale and design for a planned randomized controlled trial comparing Transcendental Meditation, a stress-reduction technique, with lifestyle education in the treatment of hypertension and hypertensive heart disease in urban African Americans. They pretested 170 men and women aged 20 to 70 years over a 3-session baseline period, with posttests at 6 months. Outcomes included clinic and ambulatory blood pressure, quality of life, left ventricular mass measured by M-mode echocardiography, left ventricular diastolic function measured by Doppler, and carotid atherosclerosis measured by β-mode ultrasound. This trial was designed to evaluate the hypothesis that a selected stress reduction technique is effective in reducing hypertension and hypertensive heart disease in African Americans. 相似文献
994.
Dr. Donald R. Morse D.D.S. M.A. Dr. George R. Schacterle P.M.D. Dr. M. Lawrence Furst Ph.D. M.P.H. Dr. Jordon Goldberg Dr. Brian Greenspan Dr. David Swiecinski 《Behavioral medicine (Washington, D.C.)》2013,39(4):31-39
Abstract Dentally-induced stress and relaxation-induced anxiety reduction have been correlated with salivary changes in dental patients in two recent studies. In two subsequent studies, test anxiety-induced stress and relaxation-induced anxiety reduction were correlated with salivary changes in dental students. In another study using the resazurin dye indicator, increased salivary bacterial levels were correlated with an increased dental caries incidence. As a result of these findings, it was decided to reinvestigate the effects of stress and relaxation on salivary changes and in addition to examine the effects of those conditions on salivary bacteria. The hypotheses under consideration were: (1) Salivary changes from stress to relaxation will be from opaque to translucent and from high to low protein levels; and (2) salivary bacteria will increase under the condition of stress and decrease under the condition of relaxation. The subjects were twelve dental students. Stress and relaxation were evaluated before and after meditation by verbal reports and examination of saliva for opacity, translucency, protein and bacteria (resazurin dye method). There were significant anxiety-reduction changes by the end of the meditation sessions (p < 0.001) as measured by increased salivary translucency, decreased salivary protein and reduced subjective evaluation of stress. Using the resazurin dye method, bacterial levels showed a significant decrease by the end of the meditation sessions (p < 0.001). The results support hypothesis 1 and reaffirm previous findings in regard to the effectiveness of: (1) salivary changes as measures of stress and relaxation; and (2) meditation to induce deep relaxation. The finding of high bacteria levels under stress and lower bacterial levels under relaxation supports hypothesis 2 and indicates that stress may contribute to dental caries and relaxation may have an anti-caries effect. 相似文献
995.
996.
997.
《Renal failure》2013,35(3):459-469
The potent endothelial-derived vasodilator nitric oxide (NO) has been identified as a protective agent in acute renal failure. However, some recent studies have suggested a detrimental effect of NO on rat proximal tubules exposed to hypoxia and reoxygenation. We determined whether NO metabolites cause intracellular oxidation during hypoxia and reoxygenation and whether this oxidative stress is linked to irreversible cell injury. Primary cultures of rat proximal tubular epithelial cells were studied in a subconfluent stage and subjected to 60 min hypoxia and 30 min reoxygenation. Intracellular oxidation was assessed by monitoring the conversion of nonfluorescent dihydrorhodamine 123 (DHR) to fluorescent rhodamine 123 as a probe for the long-lived oxidant peroxvnitrite. Hypoxia and reoxygenation produced a marked increase in cellular generation of oxidant species. Intracellular oxidation of DHR was reduced by approsimately 40% when cells were also exposed to the NO svnthase inhibitor L-NAME. Oxidation of DHR following hypoxia and reoxygenation was not affected by SOD or DATTU. A combination of SOD and L-NAME was no more effective than L-NAME alone. Hypoxia and reoxygenation produced substantial injury (as LDH release). There was a 40% reduction in LDH release when cells were pretreated with a NO synthase inhibitor. In summary, increased generation of NO capable of inducing intracellular oxidizing reactions and cell death occurred during renal hypoxia and reoxygenation. 相似文献
998.
Experience and needs of family members of patients treated with extracorporeal membrane oxygenation
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999.
This article summarizes the available evidence on the efficacy of gangliosides to reduce the degree of reactive oxygen species (ROS)-mediated damage. The antioxidative efficacy of exogenous gangliosides in protecting different cells encouraged us to examine their ability to protect human spermatozoa. Gangliosides are sialic acid-containing glycosphingolipids with strong amphiphilic character due to the bulky headgroup made of several sugar rings with sialic acid residues and the double-tailed hydrophobic lipid moiety. The amphiphilicity of gangliosides allows them to exist as micelles in aqueous media when they are present at a concentration above their critical micellar concentration. The protective effect of ganglioside micelles on spermatozoa is believed to stem from their ability to scavenge free radicals and prevent their damaging effects. In our study, we particularly focused our attention on the protective effect of ganglioside micelles on DNA in human spermatozoa exposed to cryopreservation. The results indicate that ganglioside micelles can modulate the hydrophobic properties of the sperm membrane to increase tolerance to DNA fragmentation, thus protecting the DNA from cryopreservation-induced damage. Further actions of ganglioside micelles, which were documented by biochemical and biophysical studies, included (i) the modulation of superoxide anion generation by increasing the diffusion barrier for membrane events responsible for signal translocation to the interior of the cell; (ii) the inhibition of iron-catalysed hydroxyl radical formation due to the iron chelation potential of gangliosides; and (iii) inhibition of hydrogen peroxide diffusion across the sperm membrane. 相似文献
1000.
《The world journal of biological psychiatry》2013,14(1):34-37
Behavioural changes in rats two weeks after inescapable shock stress were studied using a shuttle-box task (active avoidance/escape). Rats exposed to inescapable shock stress two weeks beforehand showed more frequent avoidance responses and greater within-group variation in both avoidance response and general activity during the test than rats in a control group. General activity during an unstressful period (before starting the test) did not differ significantly between groups. This relatively prolonged increase in responsiveness to external stimuli in the stressful context may be a useful experimental model of posttraumatic stress disorder, especially in relation to hypervigilance. 相似文献