立足临床、紧跟前沿:“生物安全医疗救治及重要传染病临床诊治新进展”研讨会纪要

正2016年11月18日至21日,第九期全军新发突发传染病防治技术培训班暨"生物安全医疗救治及重要传染病临床诊治新进展"研讨会在解放军第三〇二医院举行。会议邀请了国内著名的传染病防治领域的专家、学者对当前我国面临的生物安全形势进行了分析与研判,并就新发突发传     

Assessment of Farm‐Level Biosecurity Measures after an Outbreak of Avian Influenza in the United Kingdom

During Avian Influenza outbreaks in England, the ‘AI Order’ states that a poultry keeper may be required to keep domestic birds separate from wild birds. This study aimed to assess a) how effectively this was done and b) the negative impact this had for bird owners and animal welfare during the November 2007 Highly Pathogenic Avian Influenza (HPAI) outbreak in Suffolk, UK. A voluntary questionnaire was posted to holdings (n = 296) that were within 10 km of an infected premises; these holdings were required to separate domestic and wild birds where possible. Holdings were identified during outbreak investigations conducted by the authorities. Holdings of all sizes were included. A sample of holdings received a follow‐up visit or telephone call to validate the questionnaire (n = 29). From the 38% of eligible holdings that responded, 13% (95% CI 7–22%) left their birds outdoors throughout the outbreak. If game birds were excluded, 9% (CI 4–17%) of holdings did not house their birds. Major cost and welfare problems were rare; however, there were exceptions. Enforced housing was often relaxed before a minor welfare problem deteriorated. Contact between wild and domestic birds was greatly reduced during the outbreak, resulting in a reduced probability of HPAI transmission via wild birds for most, but not all, holdings.     

Application of Routines that Contribute to On‐farm Biosecurity as Reported by Swedish Livestock Farmers

On‐farm biosecurity is important for preventing the spread of several contagious animal diseases. In this study, biosecurity routines among Swedish farmers with livestock (cattle, pigs, sheep or goats) were examined through questionnaires posted by mail. Moreover, the use of protective clothing among professionals visiting farms, such as animal transporters and veterinarians, were investigated through assessments made by the farmers. Questionnaires were completed, partly or fully, by 518 farmers (overall response rate 34%). Possible associations between biosecurity routines and livestock species, geographic location and herd size were analysed. Large variations in biosecurity routines were found, both within and between groups, and some farms appeared to have a relatively high level of biosecurity. However, <40% of the farmers reported that they provide protective clothing for visitors, and 50% of farmers buying live animals introduced these directly into the herd without prior isolation. In general, a higher level of biosecurity was reported by farmers with herds with only pigs, when compared to farmers with cattle, sheep/goats or mixed species. A higher level of biosecurity was also reported by larger farms compared to hobby farms. Inconsistent biosecurity routines were reported, which was interpreted as a lack of knowledge of how different infections can spread and how this can be prevented. Furthermore, some replies indicated that the farmers perceived the risk of introduction of disease as low. According to the farmers’ assessments, the use of protective clothing among professionals visiting farms varied considerably, both among different professions and within the same profession. On average, veterinarians and artificial insemination (AI) technicians got high scores in this assessment, while salesmen, repairmen and animal transporters were reported to seldom use protective clothing. Based on the findings, there is room for improvement of on‐farm biosecurity. There is also a need to further investigate the motivators and constraints for altered routines among both Swedish livestock farmers and professionals visiting farms.     

Identification of Risk Factors for African Swine Fever: A Systematic Review

African swine fever (ASF) is an internationally-spreading viral pig disease that severely damages agricultural pork production and trade economy as well as social welfare in disease-affected regions. A comprehensive understanding of ASF risk factors is imperative for efficient disease control. As the absence of effective ASF vaccines limits disease management options, the identification and minimisation of ASF-associated risk factors is critical to preventing ASF outbreaks. Here, we compile currently known potential ASF risk factors identified through a systematic literature review. We found 154 observation-based and 1239 potential ASF risk factors, which we were able to group into the following defined risk categories: ‘ASF-virus’, ‘Biosecurity’, ‘Disease control’, ‘Environment’, ‘Husbandry’, ‘Movement’, ‘Network’, ‘Pig’, ‘Society’ and ‘Surveillance’. Throughout the epidemiological history of ASF there have been similar risk categories, such as ‘Environment’-related risk factors, predominantly reported in the literature irrespective of the ASF situation at the time. While ASF risk factor reporting has markedly increased since 2010, the majority of identified risk factors overall have referred to domestic pigs. The reporting of risk factors for ASF in wild boar mostly commenced from 2016 onwards. The compendium of ASF risk factors presented herein defines our current knowledge of ASF risk factors, and critically informs ASF-related problem solving.     

中华人民共和国生物安全法

日益严峻的生物安全形势,进一步凸显了其在国家安全战略中的地位。全国人大常委会于2020年10月17日通过的《生物安全法》,为我国加强生物安全能力建设提供了法律保障。本文结合实际,从科技发展角度对落实《生物安全法》提升应对公共卫生安全能力提出几点思考与建议。     

美军症状监测系统ESSENCE典型案例分析及借鉴

症状监测是以非特异性症候群和（或）其他相关指示数据为基础,能够对潜在生物恐怖袭击进行接近实时的监测预警。以美国为代表的发达国家已在症状监测领域开展了深入研究,而我国尚处于探索尝试阶段,我军也亟需进行症状监测实践。该文对美军症状监测系统ESSENSE的发展背景、发展历程、系统特点、监管要求等方面进行了典型案例分析,并对我军开展症状监测研究与实践提出了借鉴。     

Costs and benefits of a leaf beetle Integrated Pest Management (IPM) program II. Cost-benefit analysis

Forest health and biosecurity programs rarely capture sufficient data to enable thorough cost-benefit analyses to be done. One notable exception has been Forestry Tasmania’s research project to develop and use an Integrated Pest Management (IPM) program for the leaf beetle Paropsisterna bimaculata. For this project we were able to estimate all major costs and benefits in monetary terms for the period 1975–2034, to allow analysis of a ‘control’ and a ‘no control’ option across a full rotation.

Overall, the 1975–2034 leaf beetle IPM project provided a net positive return at a 5% discount rate. However, the case study was atypical because research commenced nearly three decades before the IPM program was used operationally in the expanding eucalypt plantation estate. For this reason, the year 1990, when research on the precursor of the operational IPM program commenced, was chosen as the default base year for commencing cash-flow analyses. The present value (in AU$ as at 2015) of the total expenditure between 1990 and 2034 on research to develop the leaf beetle IPM program and on its operational use was $5.4 million, of which nearly 60% was expended on research. The research costs included costs to develop the operational IPM program using conventional insecticides and costs involved in unsuccessful attempts to develop an IPM program using more environmentally friendly control options. When research expenditure was restricted to that needed for developing an IPM program using conventional insecticides, the internal rate of return from the project exceeded 7.5%. Additional timber yields from using the IPM program translated to additional revenues, which resulted in positive cash flows after 2011. The benefit:cost ratio resulting from the operational use of the IPM program (treating research expenditure as sunk costs) was 7.5.

The long interval between commencing research, and applying the IPM program operationally once the plantation estate had become established, is not typical of the circumstances relating to future pest threats. Nonetheless, the findings from our study are still relevant to projects involving future pests that may cause similar damage. Another finding of the study was that research needed for future projects to develop an operational pest management program will provide greater benefit if done centrally and the resultant program adopted broadly by as many affected plantation owners as possible.