大鼠脾脏形态学的年龄变化

本文用组织学和组织化学方法对SD大鼠脾脏的年龄变化进行了观察。大鼠脾脏中白髓随增龄而逐渐减少,结构紊乱,淋巴细胞密度下降。白髓和红髓分界不清。巨噬细胞及中性粒细胞数量增多。ANAE、ACP、AlP活性随增龄而加强。ATP酶无明显变化,SDH、LDH和5-Nase活性下降,说明老龄鼠脾脏细胞中的代谢活动发生了一定的变化。     

Aging changes of the capillary density of spinal cord in rats

'The VaSCtilar myelopathy is me~ng with bang,which has atheted attention in China and other.ountri..[l]. Previous studies were involVed the sourceand ~ of the outside nIOOd submIt to the suitalcold, but there is no systematic ~ on the qUantitativecapilleq denSity in the spinal conl[2]. The aim Of thisstudy is to observe the capilleq denSity in diffemonffeage acs and explore the changes of the capillapdensity in the spinal cOld and PIDvide morpholopcal reference for the basic study on the…     

Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized,Double-Blind,Controlled Study

The increase in solar ultraviolet radiation (UVR) that reaches the Earth’s surface should make us reflect on the need to develop new approaches in protecting the skin from UVR exposure. The present study aims to evaluate the photoprotective and antiaging efficacy of a red orange extract (100 mg/day) in both Asian and Caucasian subjects. A randomized, double-blind, controlled study was carried out in 110 Asian and Caucasian subjects. Product efficacy was measured as follows: (1) the photoprotective effect was measured by the minimal erythema dose (MED) assessment; (2) the efficacy in decreasing the UVA+B-induced skin redness was measured by colorimetry; (3) the antioxidant efficacy was measured by the ferric-reducing antioxidant power (FRAP) and the malondialdehyde (MDA) assay; and (4) skin moisturization, skin elasticity, skin radiance, the intensity of melanin staining, transepidermal water loss (TEWL), and wrinkles were measured to assess the antiaging efficacy. The intake of the product for 56 days was effective in improving the skin reaction to UV exposure; in increasing the skin antioxidant capacity as well as in decreasing UVA-induced lipid peroxidation; in increasing the skin moisturization, skin elasticity, and skin radiance; and in decreasing TEWL, the intensity of melanin staining inside dark spots, and wrinkle depth. Our results suggest that the test product is effective in counteracting both the harmful effects of UVR exposure and aging signs.     

3D Printed Customized Facemask for Maxillary Protraction in the Early Treatment of a Class III Malocclusion: Proof-of-Concept Clinical Case

In order to improve fit and comfort, a maxillary protraction facemask customized to the patient’s anatomy was produced by means of 3D face scanning, digital design and additive manufacturing. An 8-year-old patient in need of early treatment for the Class III malocclusion received a rapid palatal expander and a Petit-type facemask, whose components were digitally designed on a 3D scan of the patient’s face. For face scanning, the iPad Pro 2018 tablet (Apple, Cupertino, CA, USA) with the Bellus3D DentalPro application (Bellus3D, Campbell, CA, USA) was used. Facemask components were modelled with 3D Blender software. The rests were 3D printed in BioMed Clear biocompatible resin (Formlabs, Somerville, MA, USA), and the bar in stainless steel. For greater comfort, the internal surface of the rests was lined with a polymer gel pad (Silipos, Niagara Falls, NY, USA). The manufacturing procedure of the customized facemask is patented. The patient wore the facemask at night for a period of 9 months. The patient’s experience was evaluated with a questionnaire at 1 week, 3, 6, and 10 months of treatment. The customized facemask was well accepted by the patient and obtained the expected treatment outcome. Furthermore, 3D face scanning, 3D modelling and 3D printing allow for the manufacturing of customized facemasks with improved fit and comfort, favoring patient compliance and treatment success.     

基于可持续的我国健康老龄化路径选择

日趋严峻的人口老龄化形势,已给我国经济社会,特别是医疗卫生系统带来了巨大的挑战。描述了我国人口老龄化的态势及其特点,分析了我国老年人群的健康现状及卫生服务需求的特点,得出健康老龄化是我国解决人口老龄化问题的必然选择,阐述了我国实现健康老龄化的路径。     

魔芋精粉对大鼠脑、肝、心血管细胞老化的影响

本文用含１％魔芋精粉的饲料喂饲大鼠１８个月，观察魔芋精粉对大鼠细胞老化的影响。结果表明，长期食用魔芋精粉可延缓脑神经胶质细胞、心肌细胞和大、中动脉内膜内皮细胞的老化进程，预防动脉粥样硬化，改善心、脑和血管的功能。     

运动对脑老化小鼠学习记忆能力及突触可塑性的影响

目的从突触可塑性方面探讨运动的抗脑老化作用及其机制。方法雄性ICR小鼠40只分为4组,即脑老化模型组、脑老化+运动组、运动对照组、普通对照组,每组10只。以电动跑台进行有氧跑步运动,速度25m/min,持续运动20min,每天运动1次,每周运动6d,休息1d。以D-半乳糖100mg/kg·d颈背部皮下注射制备脑老化模型。实验干预期共9周。以Morris水迷宫测试小鼠空间记忆和学习能力,流式细胞术测定皮层海马神经元突触体数量,荧光偏振法测定突触体膜流动性,羟胺比色法测定脑组织乙酰胆碱酯酶(AChE)活性。结果(1)水迷宫实验中,脑老化组小鼠的逃避潜伏期(EL)明显大于普通对照组小鼠(P<0.05),脑老化+运动组小鼠的EL低于脑老化组(P<0.05)而与普通对照组无显著差异,运动对照组与普通对照组小鼠的EL无显著差异(P>0.05)。(2)脑老化组和脑老化+运动组小鼠突触体数量低于非脑老化组(运动对照组和普通对照组,P<0.05),脑老化+运动组高于脑老化组(P<0.05),运动对照组与普通对照组无显著差异(P>0.05)。(3)突触体膜流动性:脑老化组小鼠突触体膜粘滞度高于非脑老化组并且高于脑老化+运动组(P<0.05),脑老化运动组与非脑老化组之间、运动对照组与普通对照组之间无显著差异(P>0.05)。(4)脑老化组和脑老化+运动组小鼠脑组织AchE活性高于非脑老化组(P<0.05),运动对照组与普通对照组之间无显著差异(P>0.05)。结论运动能够减轻脑老化小鼠空间学习记忆能力的衰退。     

昆山市人口老龄化及危险因素改变对前10位死因及其死亡率的影响研究

目的　通过对影响昆山市前 10位死因及其死亡率的人口老龄化及危险因素进行定量分析 ,以达到正确评价危险因素对各主要死因作用之目的。方法　对 1981年与 2 0 0 1年 2 0年前后前 10位死因及其死亡率变化进行分析 ,定量计算人口老龄化及危险因素在其中的作用。结果　老龄化是前 10位死因及其死亡率上升的因素 ,而危险因素是前 9位死因及其死亡率降低的因素。结论　昆山市 1981～ 2 0 0 1年前后全死因及各主要死因及其死亡率的上升是由于人口老龄化引起的。人口老龄化是各死因及其死亡率上升因素 ,而危险因素是主要死因及其死亡率降低因素 ,两者作用的能量强弱变化决定着某死因及其死亡率的升降结果。     

艾灸对衰老模型大鼠线粒体DNA含量的影响

目的:探讨艾灸对衰老模型大鼠肝细胞线粒体DNA含量的影响。方法:将36只SD大鼠随机分为3组:青年对照组、衰老模型组、艾灸治疗组。采用25%D-半乳糖溶液125mg/kg·d-1皮下注射复制衰老大鼠模型,采用紫外分光光度法观察艾灸对衰老模型大鼠肝细胞线粒体DNA含量的影响。结果:与青年对照组比较,衰老模型组大鼠肝细胞线粒体DNA含量明显增加(P<0.05);与衰老模型组比较,艾灸治疗组大鼠肝细胞线粒体DNA含量明显减少(P<0.05)。结论:艾灸可以减少肝细胞线粒体DNA的含量,从而起到延缓衰老的作用。