种植义齿在外胚叶发育异常患者牙列重建中的应用

目的 探讨种植义齿在外胚叶发育异常（ectodermal dysplasia，ED）患者牙列缺损和（或）缺失重建中应用的可行性、功能及美观效果。方法 依据临床检查及X线检查结果，将种植体植入外胚叶发育异常的患者颌骨内，当种植体与骨发生骨性整合后行义齿修复，并选择适当的附着体以增强义齿的固位。结果 5例患者共植入12颗种植体，在为期6～48个月的临床观察中，除1颗种植体周有轻度软组织炎症外，其他种植体周软组织健康状况良好，全部种植体均形成良好的骨整合，所有患者均认为义齿对美学效果、咀嚼功能、发音等均有明显改善，自信心提高。结论 在外胚叶发育异常患者牙列重建中，种植义齿可达到良好的治疗效果。     

前列腺癌及前列腺非典型增生中Ras p21的免疫组化检测

用抗ras癌基因蛋白质产物p21单克隆抗体SCI-oncogema I,采用常规ABC免疫组织化学方法检测了66例前列腺癌、46例前列腺非典型增生、20例慢性前列腺炎、50例良性前列腺增生和6例正常前列腺组织石蜡标本中p21的表达,结果显示,前列腺癌的阳性表达率明显高于其他几组病变(P<0.01),其阳性表达率随肿瘤组织学分级增高而增高。前列腺癌周的不典型增生组织对p21的反应强度显著高于单纯性不典型增生组织。上述结果说明,ras癌基因产物p21的过量表达,在前列腺非典型增生向前列腺癌的发展过程中起着重要作用,并且可以作为一种新的肿瘤标记物来估计前列腺癌的生物学行为。     

Titanium miniplate fixation for osteotomies in facial fibrous dysplasia — a histologic study of the screw/bone interface

In four patients who had osteotomies of the jaws affected by fibrous dysplasia (FD), screws embedded in bone blocks were removed at a re-entry operation 20 months postoperatively. Morphometric measurement of the bone density and calculation of the bone contact percentage were performed. Both normal and dysplastic bone were found to have some direct bone contact with the titanium screws. Although the bone contact percentage was higher in the normal bone when compared with FD, statistics failed to show any significant difference (P>0.05). The dysplastic bone healed well around the titanium screws without inflammatory reaction and direct dysplastic bone/screw contact was noted. Longer screws should be used in facial FD in order to compensate for the reduced bone contact percentage.     

Differential expression of T-cell CD3-zeta chains in patients with cervical dysplasia before and after treatment

This study addresses whether CD3-zeta suppression associated with cervical intraepithelial neoplasia (CIN) I, II, and III is mediated by a circulating factor and if this suppression is reversed following treatment. Serum was isolated from patients with CIN before and after curative therapy. Jurkat T cells were incubated with patient-derived sera for 4 days, and CD3-zeta expression was analyzed by western immunoblot. Sera from control female volunteers did not suppress CD3-zeta expression of Jurkat cells, while sera from women with CIN I, II, and III suppressed 58.9%, 75.3%, and 80.5%, respectively. Suppression observed in women with CIN I was significantly different from that observed with CIN II and III. Posttreatment zeta suppression was noted to be reversed in women with CIN II and III although the decreased suppression in CIN III patients was not statistically significant. Our study demonstrates that in vivo suppression of zeta chains in patients with CIN can be the result of a circulating factor. In vitro zeta expression increased in patients with CIN II and III after treatment, although the increase was only statistically significant in patients with CIN II.     

全髋关节置换术治疗髋臼发育不良

目的探讨全髋关节置换术治疗因髋臼发育不良(developmentaldysplasiaofthehip,DDH)致髋关节骨性关节炎的手术方法。方法1986年2月～2004年11月,对24例因DDH致髋关节骨性关节炎患者行全髋关节置换术。其中男4例,女20例。年龄33～59岁,平均47岁。双侧8例,单侧16例。主要症状为疼痛及跛行。根据Hartofilakidis分类方法,半脱位2髋,低位脱位21髋,高位脱位9髋,术前Harris评分分别为56.70±2.75、36.09±4.16及29.45±2.16分。结果术后均获随访6个月～8年,平均3年4个月。半脱位、低位脱位及高位脱位患者术后Harris评分分别为93.10±2.10、92.73±3.20及88.09±3.67分,与术前比较差异均有统计学意义(P<0.01)。术后6侧下肢轻度跛行,均无疼痛,可以长距离行走。X线片示人工髋关节位置佳,无明显松动及下沉。结论加深髋臼、内移髋关节活动中心及改进植骨方法,是增加人工臼稳定性手术成功的关键。     

Arrhythmogenic right ventricular dysplasia: MR features

Arrhythmogenic right ventricular dysplasia (ARVD) is a heart disease characterized by a total or partial fat replacement of the myocardium. A total of 30 patients were studied with a suspected diagnosis of ARVD. Clinical criteria used for evaluation of ARVD were: (a) ventricular origin arrhythmias with a left bundle branch block configuration, (b) T-wave inversion in the anterior precordial leads, (c) ventricular kinetic alterations observed using echocardiography and angiography and (d) cardiac failure when there are no pathologies attributable to other heart diseases. All patients had serial EKG and echocardiography tests. One third of patients underwent angiocardiography; 7 of 30 had Holter; 7 of 30 had exercise test just to evaluate the effectiveness of the anti-arrhythmic therapy. All patients underwent MRI examination. The following MRI criteria were used: (a) high-intensity areas indicating the fatty substitution of the myocardium, (b) ectasia of the right ventricular outflow tract, (c) dyskinetic bulges, (d) dilation of the right ventricle and (e) enlargement of the right atrium. The diagnosis of ARVD was classified as highly probable for patients manifesting at least three positive criteria, probable with two positive criteria, dubious with one and negative in the absence of all criteria. Highly probable diagnosis of ARVD was made in 8 patients, probable in 4, dubious in 7 and negative in 11. The MRI technique is very effective in the assessment of ARVD. The MRI criteria may be helpful in the diagnosis of this condition. Received 9 August 1995; Revision received 27 December 1995; Accepted 16 July 1996     

Acetabular labrum tear in a 15-year-old male: Diagnosis with correlative imaging

A 15-year-old male with unresolved hip pain after minor trauma is presented. The diagnosis of an acetabular labral tear was made using correlative scintigraphic and magnetic resonance (MR) imaging, obviating the more invasive investigations of arthrography or arthroscopy of the hip. The clinical and radiological features of this lesion are reviewed. Undiagnosed, acetabular labral tears may result in considerable morbidity. Appropriate operative or conservative management of the condition usually provides symptomatic relief.     

Blunted peripheral chemoreceptor response to hyperoxia in a group of infants with bronchopulmonary dysplasia

Infants with BPD often suffer from chronic hypoxia and require supplemental oxygen (O₂). This might affect the sensitivity of peripheral chemoreceptors. Therefore, we assessed peripheral chemoreceptor function in 25 infants with bronchopulmonary dysplasia (BPD) of varying severity, using the hyperoxic test. These infants were compared with 35 preterm infants who did not develop BPD. All infants were tested during the 40th week of postconceptional age and their mean postnatal age was 81.5 ± 16.3 days. Sixty percent (15/25) of the BPD infants lacked a hyperoxic response, while the proportion of nonresponders to O₂, among the other groups was 20% (7/35). The intensity of this response was negatively correlated to time spent on a ventilator and positively to time without supplemental oxygen. The intensity of chemoreceptor function was closely related to the severity of BPD; none of the infants with the most severe form of BPD (grade 3) showed a ventilatory response to hyperoxia. Furthermore, infants with BPD needed significantly longer time to increase their saturation than did non-BPD infants (4.7 and 9.3 sec, respectively). We conclude that many infants with BPD, particularly those with the most severe form of the disease, have abnormally functioning peripheral chemoreceptors. Pediatr Pulmonol. 1995; 20:101–106 . © 1995 Wiley-Liss, Inc.