The Relationship Between Thiamine Intake and Long Sleep Duration: Results From the Korea National Health and Nutrition Examination Survey

Objectives:Thiamine is thought to modify sleeping patterns, while alcohol use diminishes internal thiamine levels. We investigated the association between thiamine intake and sleep duration and explored possible heterogeneity in the effect according to alcohol use.Methods:In total, 15 384 participants aged 19-64 were obtained from the Korea National Health and Nutrition Examination Survey 2012-2016. Nutrient intake, including thiamine, was measured using a food frequency questionnaire. Sleep duration was measured by a self-reported questionnaire. The highest thiamine intake quartile was set as the reference group. Participants were divided into 3 groups, with 7-8 hours of daily sleep as a reference group and those who slept more or less than that as “oversleeping” and “insufficient sleeping,” respectively. Multivariate logistic regression was used, adjusting for socioeconomic, medical, and nutritional factors. Additionally, participants were stratified according to high-risk alcohol use defined by the World Health Organization standards on alcohol use.Results:Low thiamine intake was associated with oversleeping (Q3: odds ratio [OR], 1.06; 95% confidence interval [CI], 0.86 to 1.32; Q2: OR, 1.24; 95% CI, 0.99 to 1.55; Q1: OR, 1.49; 95% CI, 1.16 to 1.91) and showed a significant trend for higher ORs at lower intake levels (p-trend<0.001). The effect was stronger in the high-risk alcohol use group (Q1: OR, 1.78; 95% CI, 1.28 to 2.49).Conclusions:Low thiamine intake was associated with oversleeping, and alcohol use intensified that association. These results were found in a context where overt clinical symptoms due to thiamine deficiency are considered rare. More awareness of the potential relationship of thiamine intake with oversleeping and its related risks should be considered.     

HPLC法同时测定五维赖氨酸口服溶液中4种水溶性主成分的含量

目的:建立直接同时测定五维赖氨酸口服溶液中盐酸赖氨酸和三种水溶性维生素含量的RP-HPLC法。方法:采用Phenomenex Gemini C₁₈ 100A(4.6 mm×250 mm, 5μm)色谱柱，以0.03 mol·L^-1磷酸二氢铵溶液(pH 3.0)-甲醇(98∶2)为流动相，检测波长为205 nm,流速1.0 mL·min^-1。结果:盐酸赖氨酸、维生素C、维生素B₆和烟酰胺分别在30.56～488.9μg·mL^-1(r=1.000 0)、24.86～397.8μg·mL^-1(r=0.999 8)、1.018～16.29μg·mL^-1(r=1.000 0)、10.72～171.5μg·mL^-1(r=0.999 0)范围内与峰面积呈良好的线性关系；定量限分别为10.39、0.466 1、0.092 79、0.136 2 ng;平均回收率分别为100.6%、98.5%、98.0%、99.2%,RSD分别为0...     

Dietary intake and circulating vitamin levels of rheumatoid arthritis patients treated with methotrexate

The nutrient intakes and circulating vitamin levels of 32 patients with rheumatoid arthritis who were treated with methotrexate were evaluated over a 6-month period. Dietary data were obtained and blood was drawn prior to the initiation of and following 12and 24 weeks of methotrexate therapy. More than 50% of the patients had food intakes providing less than 67% of the recommended dietary allowance for zinc, vitamin E, foh'c acid, pyridoxine, qnd magnesium. Patients 51 years or older had better nutrient intakes than patients less than 51 years. Of the patients, 22% consumed vitamin supplements at thetime they were recruited for the study. Mean circulating vitamin levels measured over the6-month period were within normal limits. Our findings agree with previously published reports that patients with rheumatoid arthritis, particularly the subpopulation taking methotrexate, consume diets that are marginal in some nutrients. Additional research needs to be done to identify more sensitive nutrient assays and to establish more definitively the nutrient needs of patients with rheumatoid arthritis taking several therapeutic agents.     

1643例中老年人血浆同型半胱氨酸水平调查

目的调查中老年人群血浆同型半胱氨酸(Hcy)水平的参考值及与疾病的相关性。方法1643例中老年人(45～98岁)采集空腹全血,酶联免疫法测定Hcy。结果635例无心脑血管病及高血压、糖尿病的中老年人血浆Hcy水平为11.00±4.73μmol/L,95%上限为20.20μmol/L。血浆Hcy水平与年龄呈正相关,与血清叶酸、VitB12水平呈负相关,与服用维生素的年数呈负相关。服用多种维生素者血浆Hcy水平明显低于未服用者。冠心病、脑卒中、高血压组,单独存在或合并其他任一种疾病时,其血浆Hcy水平均明显高于参考值,P<0.01;冠心病与脑卒中组,在有合并症组与无合并症组之间无显著性差异,P>0.05。高血压组,在合并冠心病或脑卒中时,血浆Hcy水平明显高于单独存在时,P<0.01。糖尿病组,单独存在时,血浆Hcy水平与正常组比较无显著性差异,P>0.05。合并冠心病或脑卒中或高血压时,血浆Hcy水平明显高于无合并症组及正常组,P<0.01。结论Hcy是心脑血管疾病及高血压的重要危险因素。服用多种维生素可降低血浆Hcy水平。