不同方法检测HBeAg低值血清的效果评价

目的 通过检测HBeAg低值血清,评价ELISA方法和时间分辨免疫荧光法（IrMA）的检测效果.方法 对2014年1月至6月我院HBeAg阳性结果进行回顾性分析,同时收集门诊和住院受检人群化学发光法（CMIA）检测HBeAg结果为1.00～29.99 S/CO区间内的低值血清样本81份,采用ELISA和IFMA法进行复孔检测.结果 HBsAg阳性人群的HBeAg检测结果与HBsAg呈正相关（r=0.680,P＜0.01）.HBeAg阳性样本占HBsAg阳性样本的32.69％,HBeAg低值样本占HBeAg阳性样本的39.35％,均主要分布于青中年人群.HBeAg阳性率随HBsAg阳性人群的年龄增高而降低（x2=386.041,P＜0.01）.ELISA和IFMA法检测HBeAg低值样本的阳性率分别为60.49％和45.68％,两者比较差异无统计学意义（x2=3.569,P＞0.05）.两种方法在检测1.00～4.99S/CO、5.00～29.99 S/CO水平的阳性率分别为25.64％、92.86％（ELISA）和10.26％、78.57％（IFMA）.相关性分析中,ELISA和IFMA法检测HBeAg低值样本的结果与CMIA方法检测结果均呈明显正相关（r=0.868和0.858,P＜0.01）.结论 由于方法灵敏度方面的原因,ELISA和IFMA法在检测HBeAg低值样本时存在较高比例的漏检情况,因此上述两种方法不适用于检测HBeAg低值样本以评估受检者感染HBV的疾病状况.     

A Formal Mentorship Program for Faculty Development

Objective. To describe the development, implementation, and evaluation of a formal mentorship program at a college of pharmacy.Methods. After extensive review of the mentorship literature within the health sciences, a formal mentorship program was developed between 2006 and 2008 to support and facilitate faculty development. The voluntary program was implemented after mentors received training, and mentors and protégés were matched and received an orientation. Evaluation consisted of conducting annual surveys and focus groups with mentors and protégés.Results. Fifty-one mentor-protégé pairs were formed from 2009 to 2012. A large majority of the mentors (82.8%-96.9%) were satisfied with the mentorship program and its procedures. The majority of the protégés (≥70%) were satisfied with the mentorship program, mentor-protégé relationship, and program logistics. Both mentors and protégés reported that the protégés most needed guidance on time management, prioritization, and work-life balance. While there were no significant improvements in the proteges’ number of grant submissions, retention rates, or success in promotion/tenure, the total number of peer-reviewed publications by junior faculty members was significantly higher after program implementation (mean of 7 per year vs 21 per year, p=0.03) in the college’s pharmacy practice and administration department.Conclusions. A formal mentorship program was successful as measured by self-reported assessments of mentors and protégés.     

苏云金芽孢杆菌以色列变种的两种漂浮颗粒剂灭中华按蚊幼虫效果比较

用美国Ｂａｃｔｉｍｏｓ可湿性粉剂（Ｂｔｉ－１８９７）和国产Ｂｔ－１８７乳剂生产的两种漂浮颗粒剂灭中华按蚊幼虫的结果表明：后者对中华按蚊幼虫的效价（１２０ＩＴＵ／ｍｇ）比前者（３７０ＩＴＵ／ｍｇ）低，但制成颗粒剂后（效价２２０ＩＴＵ／ｍｇ）比前者（效价１３０ＩＴＵ／ｍｇ）高。稻田应用０．８１ｇ／ｍ２剂量Ｂｔ－１８７漂浮颗粒剂控制中华按蚊幼虫，持效可达１６天，Ｂａｃｔｉｍｏｓ漂浮颗粒剂为１３天。