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71.
Schistosoma mansoni infection, both in humans and in animal models, is known to induce granulomas in the liver and intestine. It has also been
reported that in humans the eggs of this parasite can reach the brain, causing psychiatric and neuropathological disorders.
Whether this also occurs in rodents is unknown. To answer this question, mice were infected with this parasite and the central
nervous system (CNS) examined at various time intervals. The results show that schistosomiasis induced granulomas in several
regions of the CNS and increased nerve growth factor (NGF) levels in the cortex, hypothalamus and brain stem, but not in the
hippocampus. The infection also caused paw hyperalgesia, as determined by the hot-plate test, and a local increase in NGF,
but not in substance P. These findings indicate that the murine model of infection can be used for studying mechanisms leading
to human neuroschistosomiasis and suggest that the neuropathological disorders and the sensory deficits observed in human
schistosomiasis are associated with impaired levels of NGF in the peripheral and central nervous system.
Received: 18 January 1996 / Revised, accepted: 16 April 1996 相似文献
72.
CT增强扫描在评价NSCLC血管生成中的临床意义 总被引:3,自引:3,他引:0
目的 探讨非小细胞肺癌 (NSCLC)血管内皮生长因子 (VEGF)的表达水平与CT增强程度的关系 ,从影像学角度评价肿瘤血管生成在肺癌诊断、治疗及淋巴结转移中的临床价值。方法 对 30例NSCLC病人进行动态螺旋CT扫描 (SCT) ,测量病灶增强幅度 ,并利用免疫组化技术检测VEGF。对病灶增强值、VEGF阳性表达及淋巴结转移情况进行统计学分析。结果 30例肺癌病人CT增强值均数为 (36 .2 8± 6 .41 )HU ,VEGF阳性表达 2 1例 ,阴性表达 9例。VEGF在中晚期的阳性表达高于早期病人 (Ρ<0 .0 5) ,淋巴结转移组高于非淋巴结转移组 (Ρ <0 .0 5) ;癌灶增强值与VEGF阳性表达、肿瘤分期及淋巴结转移亦呈正相关。结论 NSCLC的CT增强程度能够反映肿瘤的血管生成 ,并与淋巴结转移密切相关 ,有助于肺癌的诊断、TNM分期 ,而且可以从肿瘤分子生物学行为方面补充目前肺癌分期方法的不足 相似文献
73.
经临床鉴定静脉内注射小儿氨基酸对治疗胎儿宫内发育迟缓具有肯定效果。在B超监视下,使用小儿氨基酸的孕妇组于用药期间,胎儿生长参数BPD和HC显著高于使用成人氨基酸的孕妇组。10例足月娩出胎儿体重均达到甚至超过2.5kg。由此得出结论:使用小儿氨基酸注射液对于改善胎儿宫内发育迟缓优于成人氨基酸。 相似文献
74.
75.
对生长激素缺乏症(GHD)患儿生长激素(GH)治疗前后的免疫功能改变进行了观察。结果显示:(1)GHD患儿NK细胞活性明显降低,经GH治疗3个月后恢复到正常水平;(2)GHD患儿治疗前IL-1a和IL-2活性偏低,治疗后两者有逐渐增高的趋势;(3)治疗前后CD细胞亚群、sIL-2R和LPS诱生的TNFa含量均无明显变化。认为GH缺乏症患儿存在一定的免疫功能缺陷,而GH有调节其免疫功能的作用。 相似文献
76.
Estil Y. Strawn Jr. MD Miles J. Novy MD Kenneth A. Burry MD Cynthia L. Bethea PhD 《American journal of obstetrics and gynecology》1995,172(6):1837-1844
Objective: Our purpose was to determine whether insulin-like growth factors I and II preferentially stimulate uterine leiomyoma cells versus myometrial cells in monolayer culture.Study design: Leiomyomas and normal myometrium were obtained at hysterectomy from five premenopausal women. Specimens were enzymatically digested for use in primary monolayer cell cultures. By use of serum-free media, insulin-like growth factor I or II was added in 1, 10, and 100 ng/ml concentrations to both cell types with the patient serving as her own control. Cell number, prolactin production, and proliferative index values were measured on day 15 of cell culture.Results: Significant increases in cell number were found in the leiomyoma cultures (p < 0.05) treated with 10 and 100 ng/ml insulin-like growth factors I but not with insulin-like growth factos II. Neither factor exerted a stimulatory effect on myometrial cells.Conclusion: Insulin-like growth factor sI preferentially stimulates leiomyoma cells in monolayer culture. These results suggest an autocrine-paracine role in vivo for this factor in conjuction with gonadal steroids in promoting leiomyoma growth. 相似文献
77.
Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer 总被引:10,自引:0,他引:10
Masakazu Toi Seigo Hoshina Toshiaki Takayanagi Takeshi Tominaga 《Cancer science》1994,85(10):1045-1049
Angiogenesis is an independent prognostic indicator in breast cancer. In this report, the relationship between expression of vascular endothclial growth factor (VEGF; a selective mitogen for endothelial cells) and the microvessel density was examined in 103 primary breast cancers. The expression of VEGF was evaluated by immunocytochemical staining using anti-VEGF antibody. The microvessel density, which was determined by immunostaining for factor VIII antigen, in VEGF-rich tumors was clearly higher than that in VEGF-poor tumors ( P <0.01). There was a good correlation between VEGF expression and the increment of microvessel density. Furthermore, postoperative survey demonstrated that the relapse-free survival rate of VEGF-rich tumors was significantly worse than that of VEGF-poor tumors. It was suggested that the expression of VEGF is closely associated with the promotion of angiogenesis and with early relapse in primary breast cancer. 相似文献
78.
我国较贫困地区农村学龄前儿童膳食状况 总被引:5,自引:0,他引:5
对1985~1989年7省较贫困的18个乡农村儿童膳食调查资料采用平均摄入量、临界值及概率法进行了总结分析。结果表明,6~24月龄母乳喂养儿的辅食品种单一,数量不足。断奶儿童各年龄组热能、蛋白质摄入量的平均值分别达RDA的92%~104%和76%~84%,但以RDA为界值,仍有53%~62%及74%~85%的儿童热能、蛋白质摄入量低,用概率法分析蛋白质、钙、维生素A、B2、C及铁摄入不足的人数比例分别是50%~60%、93%~97%、51%~87%、74%~86%、58%~66%和12%~47%。热能、蛋白质摄入量低于RDA值儿童的身高、体重明显低于摄入量高于RDA值的儿童。 相似文献
79.
The growth and development of vegan children 总被引:1,自引:0,他引:1
The results of prospective study on the growth and diets, estimated from 7-day weighed food intake records, of 20 life vegan children (aged 5.8–12.8 years) are presented. The growth and development of the children were normal but they tended to be lighter in weight and exceptionally lean compared with standards. Heights were around the median of the Tanner-Whitehouse standards but were lower than the medians recently proposed by the Department of Health. Energy intakes were similar to those reported in children of the same age in the general population, but dietary fibre intakes were very high which may have influenced the digestible energy. Sugar provided an average 15.6% of the dietary energy and this was supplied mainly by fruit and fruit juice. Mean fat intakes were close to the dietary reference values. Daily intakes of essential nutrients generally met the amounts recommended, with the exceptions of calcium and vitamin B12 . Many children received supplementary sources of vitamin B12 and only two children had intakes below the lower recommended nutrient intake. Intakes of saturated fatty acids were low and those of linoleic acid were high. The ratio of linoleic/α-linolenic acid was high. As docosahexaenoic acid is absent from vegan diets, it is suggested that vegans should use oils with a lower ratio of linoleic/α-linolenic acid. Future studies should also consider the influence of a vegan diet on retinal function. None of the children was immunized against whooping cough and 11 had not been immunized against polio: 16 of the children had suffered from whooping cough. Future studies need to take into account factors other than diet when assessing the health of vegans. The results of this study show that children can be successfully reared on a vegan diet providing sufficient care is taken to avoid the known pitfalls of a bulky diet and vitamin B12 deficiency. 相似文献