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71.
Masahiro Tachi Shinichi Hirabayashi Harumi Harada Takeki Nishio 《Journal of plastic surgery and hand surgery》2013,47(5):305-308
We have recently encountered three cases of streptococcal toxic shock syndrome, each of which had a different cause. All the patients had inflammation of soft tissue in the lower extremities, and developed shock and multiple organ failure immediately after the clinical visit. The inflammation of soft tissue was necrotising fasciitis in one case, myositis in one case, and phlegmon in one. In the first case the debridement was incomplete, which resulted in an extensive ulceration. Wary of repeating this experience, we made an early diagnosis and did a thorough debridement in the second case. The patient was ultimately discharged without complications. It is rare that a patient with extensive myositis survives without amputation of the extremity. The third patient responded well to early treatment with antibiotics. 相似文献
72.
小儿中毒性表皮坏死松解症15例临床分析 总被引:4,自引:1,他引:3
本文对15例小儿中毒性表皮坏死松解症(TEN)进行回顾性分析。男性7例,女性8例,剥脱面积占体表面各45% ̄98%不等。15例患者均有用药史,致敏药物以镇静抗癫痫药物为首,死亡1例,后遗症5例。归纳总结出小儿TEN的诊断标准。关于皮腩类固醇激素在治疗TEN中的应用,我们认为早期短期应用是必要的,主意纠正水、盐、电解质平衡的紊乱,营养的供应和皮肤粘膜的护理。 相似文献
73.
目的探讨脑电图模式及动态监测对中毒性昏迷患者的应用价值。方法回顾性研究119例中毒性昏迷患者临床资料及不同时间段的长程脑电图模式。结果脑电监测显示除安定中毒以B昏迷为主外,其余各类中毒性昏迷患者均以弥漫性慢波异常的Ⅴ型脑电构型多见;预后方面脑电构型Ⅰ型全部预后不良,Ⅱ型及Ⅲ型预后不良率为81.8%及60.0%,Ⅴ型预后最好,不良率仅为2.9%;复查时脑电显示改善者临床预后良好,而脑电恶化者临床预后不良。结论中毒性昏迷者的脑电图构型对判断昏迷程度和预后有一定意义,而对昏迷病人进行长程脑电动态监测,能为预詹判断提供动态和更为准确的信息。 相似文献
74.
目的:通过藏药吉堪明目液的急性毒性、长期毒性与眼部刺激性实验,观察其毒性反应。方法:观察吉堪明目液对小鼠灌胃,测定最大耐受量的毒性反应;对家兔短期多次滴眼(15min/次,2h)与常规治疗7d滴眼(3次/d,7d)对兔眼的刺激情况;以1.1g/kg、0.56g/kg、0.28g/kg剂量组连续滴眼(4次/d)30天后,观察家兔每周体重、重要脏器系数、血象、血生化指标变化及眼球、重要脏器的病理检测。结果:吉堪明目液对小鼠最大耐受量(MTD)为生药39g.kg-1,无任何不良反应;短期多次给药眼刺激和常规治疗7天给药刺激性试验对兔眼角膜、虹膜、结膜综合评分为0,均无刺激作用,眼球病理检测无异常;连续滴眼30天后外观行为、每周体质量、血液学和血液生化学、脏器系数、与空白组比较无明显差异;眼球和脏器病理检测未发现与药物相关的明显病变,停药后也未见药物延迟毒性反应。结论:本藏药制剂未发现毒性反应,其临床应用是安全和无刺激的。 相似文献
75.
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77.
Tetrahymena thermophila (T. thermophila) BF5 produces heat through growth and metabolism. By microcalorimetry, the power‐time curves of the metabolism of T. thermophila BF5 at 28 °C were measured and some quantitative parameters were obtained from these curves. Then the action of berberine on this microbe was investigated. Furthermore, the minimum inhibitory concentration (MIC) of berberine against T. thermophila BF5 growth was obtained by tube dilution method. Berberine of different concentrations had various actions on T. thermophila BF5 growth: a low concentration (25 μg/ml) of berberine began to inhibit the growth of T. thermophila BF5 and a high concentration (450 μg/ml) of berberine completely inhibited T. thermophila BF5 growth. The toxic action of berberine could also be expressed as half‐inhibitory concentration IC50, i.e., 50% effective in this inhibition. The value of IC50 was 175.60 μg/ml, while the MIC of this compound against T. thermophila BF5 was 20.76 mg/ml. Berberine has strong toxic action on T. thermophila BF5 growth. The microcalorimetric method for the assay of toxic action is quantitative, inexpensive and versatile. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
78.
Summary A 37-year-old woman died after 18 days from her starting to take sulindac for low back pain. Based on her clinical course and the autopsy findings, the cause of her death was Lyell syndrome (toxic epidermal necrolysis) induced by sulindac. This case is described together with the legal aspects of medical malpractice to which it gave rise. 相似文献
79.
本文自1965年元月至1983年元月、对102例先天性巨结肠根治术进行了临床分析和远期疗效观察,早期治愈96例(94.12%),死亡6例(5.88%)。获得随访80例,晚期死亡3例(3.75%)。此外,对术后排便功能,肠管切除范围,术后复发原因,手术年龄及并发症等进行了讨论。 相似文献
80.
In order to exploit the protein rich (47.7 g/100 g) simarouba meal in food/feed, studies were conducted on its chemical composition with emphasis on protein characteristics and toxic constituents. Simarouba meal contained high calcium (143 mg/100 g) and sodium (79 mg/100 g). Saponins with triterpenoid aglycone (3.7 g/100 g), alkaloids (1.01 g/100 g), phenolics (0.95 g/100 g) and phytic acid (0.73 g/100 g) were the major toxic constituents identified in simarouba meal. TLC and HPLC results indicated that among different fractions of simarouba saponins, one dominant fraction accounted for about 28%. Proteins of simarouba recorded high in vitro digestibility (88%). SDS–PAGE revealed four major protein bands in molecular weight ranges of 20–24, 36–45 and 55–66 kDa. Apart from, glutamic acid (23.43 g/100 g protein) and arginine (10.75 g/100 g protein), simarouba protein contained high essential amino acids like leucine (7.76 g/100 g protein), lysine (5.62 g/100 g protein) and valine (6.12 g/100 g protein). Among nutritional indices, simarouba meal recorded a good EAA Index (75.02), C-PER (1.90) and PDCAAS (1.0-Adult group). 相似文献