消痛救心散联合消心痛治疗冠心病心绞痛50例疗效观察

目的观察消痛救心散治疗冠心病心绞痛的临床效果。方法80例冠心病心绞痛患者随机分为治疗者50例和对照组30例,治疗组应用消痛救心散联合消心痛治疗,对照组单用消心痛治疗,观察2组疗效。结果治疗组心绞痛治疗有效45例（90．0％）,对照组有效19例（63．3％）。2组比较差异有统计学意义（P〈0．01）。治疗组心电图疗效有效33例（66．0％）,对照组有效10例（33．3％）。2组比较差异亦有统计学意义（P〈0．05）。结论消痛救心散治疗冠心病心绞痛效果满意,值得临床推广应用。     

核酪注射液联合酮替芬治疗小儿支气管哮喘抗复发疗效分析

目的探讨核酪注射液与酮替芬对小儿支气管哮喘抗复发的效果.方法将179例支气管哮喘患儿随机分为抗复发组和对照组,抗复发组采用核酪注射液和酮替芬胶囊综合治疗与对照组进行疗效观察.结果抗复发组疗效明显优于对照组,抗复发组l23例痊愈率68.07%对照组56例痊愈7.l4%两组比较差异具有统计学意义.结论核酪联合酮替芬治疗小儿支气管哮喘抗复发疗效可靠,值得临床推广应用.     

Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains

Ethnopharmacological relevance

Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD).

Aim of the study

To investigate the effect of TLJN on β-amyloid-degrading enzymes and learning and memory in the AD rat brain.

Materials and methods

AD rats whose disease was induced by Aβ_25-35 injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN min, TLJN max and donepezil hydrochloride groups. Spontaneous alternation and passive avoidance behavior, which are regarded as measures of spatial learning and memory, were investigated using Y-maze testing. Western blotting and immunohistochemistry were used to observe the therapeutic effect of TLJN on the deposits of amyloid plaque and on the expression of synaptophysin, insulin-degrading enzyme and neprilysin.

Results

Y-maze results showed that the AD model group presented with spatial learning and memory impairments. Hematoxylin-eosin and Congo red staining indicated neuronal impairment and deposits of amyloid plaque in the model group and these results were consistent with their learning and memory deficits in the Y-maze. The TLJN-treated groups exhibited prolonged a cavity delitescence, decreased arm entries and improvement in learning and memory. Moreover, the structure of the neurons of the treated groups was restored and the expression of synaptophysin increased in both the hippocampus and cortex. In addition, their levels of insulin-degrading enzyme and neprilysin in the cortex and hippocampus were upregulated and the amyloid plaque was decreased.

Conclusion

TLJN can improve learning and memory, up-regulate insulin-degrading enzyme and neprilysin levels, promote the degrading of Aβ and clear amyloid plaque from the AD rat brain. In future, TLJN may have significant therapeutic potential in the treatment of AD patients.     

防风通圣散治疗肥胖症的研究现状

国内外学者就防风通圣散治疗肥胖症进行了较为深入的研究,取得了不少成果。查阅近30年的相关文献报道,分别从动物试验和临床研究两个方面就其现状予以综述。通过整理分析文献发现：（1）相关文献数量较少;（2）动物实验文献更少,且多数由国外学者完成;（3）早期临床试验不尽规范;（4）防风通圣散是中医临床治疗肥胖症的常用方剂,其疗效确切,安全性高,值得深入研究。     

长龙通注射液对纤维蛋白溶解酶活性的影响

长龙通注射液对家兔、豚鼠增加纤维蛋白溶解酶活性，给药后20min,50min时最显著，90min后作用明显减弱或恢复正常，在家兔连续多次给药实验中，测定给药20min时纤维蛋白溶解酶活性显著增加（P＜0．01），凡给药24h后测定，纤维蛋白溶解酶活性均不见明显增强，说明长龙通注射液中增加纤维蛋白溶解酶活性的有效成分在体内没有蓄 积作用，有效作用时间短。     

临潼温泉水漂浮疗法对老年原发性高血压病的疗效观察

目的 观察以解放军临潼第一疗养院温泉水作为漂浮液的漂浮疗法对老年原发性高血压病的治疗效果。方法 以随机抽样的方式将我院1998年3月至2001年3月收住院的患有原发性高血压病的疗养员分为漂浮组和对照组。两组疗养员均继续服用医嘱降血压药，并且均进行基础疗养措施，但漂浮组增加应用温泉水为漂浮液的漂浮治疗，治疗前后分别填写SCL－90症状自评量表，对照观察两组疗效。结果 经1个月疗养后，漂浮组病人的收缩压与舒张压均明显下降，有效率为67％；而对照组有效率仅为13％。两组疗养员的精神症状均有改善，以漂浮组改善更为明显。结论：临潼温泉水漂浮疗法是治疗原发性高血压病的有效辅助治疗方法。     

维脑路通治疗急性期脑出血大鼠实验研究

用维脑路通对大鼠进行急性期脑出血的治疗研究,结果表明,维脑路通对动物的肢瘫治愈率达100％,动物死亡率为5％。该药能扩张血管,促进血肿吸收,使血小板功能恢复正常。用维脑路通治疗急性期脑出血效果可靠。     

穴位敷贴癌痛灵治疗癌性疼痛的实验研究

通过悬浮液接种法造成lewis肺癌模型 ,瘤区组、郄穴组分别敷贴癌痛灵 ,测定各组小鼠的基础痛阈、耐痛阈。结果 :癌痛灵敷贴瘤区加郄穴有良好止痛作用。郄穴组敷贴癌痛灵 1小时及一疗程后痛阈、耐痛阈明显提高 ,对缓解癌痛作用迅速、明显 ,总有效率达 85 %。     

依达拉丰联合疏血通治疗脑梗死(附32例疗效观察)

目的观察依达拉丰联合疏血通治疗发病72 h以内的脑梗死疗效。方法选择发病72 h以内的脑梗死64例,随机分为两组:治疗组32例,依达拉丰30 mg,静滴,2次/d,14 d;疏血通8 mL,静滴,1次/d,14d。对照组:低分子右旋糖酐500 mL加复方丹参16 mL,静滴,1次/d,14 d。治疗前后两组病例分别进行神经功能缺损评分,测定血尿常规、血液流变学、肝肾功能、大便潜血等,并进行两组比较,同时观察其副作用。结果治疗组神经功能缺损评分减少较对照组明显(P<0.01),总有效率(96.88%)亦较对照组(75%)高(P<0.01),且血液流变学指标较治疗前明显改善(P<0.01),与对照组相比差异具有显著性(P<0.01)。结论依达拉丰联合疏血通治疗发病72 h内的脑梗死安全有效。     

浅谈仝小林运用葛根经验

总结整理仝小林教授运用葛根的临床经验。仝教授擅于运用葛根舒利经气、升发脾胃清阳之性治疗头痛、斜颈、消渴、下利等多种疾病,对临床用药有指导意义。