乌梅丸合痛泻要方治疗溃疡性结肠炎30例

为观察乌梅丸合痛泻药方治疗溃疡性结肠炎的临床疗效及对NO的影响。选取治疗组和对照组各30例,治疗组应用乌梅丸合痛泻药方内服加保留灌肠;对照组应用补脾益肠丸,两组疗程均为30天。观察治疗前后大便次数和性状、腹痛、结肠镜、钡剂灌肠的变化,并采用硝酸还原法测定血清NO3^-浓度以反映一氧化氮（NO）生成情况。结果：治疗组临床治愈12例,有效10例,总有效率73．3％;对照组临床治愈7例,有效9例,总有效率53．3％（P＜0．05）。两组治疗后,血中NO浓度均有所下降,但治疗组明显优于对照组（P＜0．01）。提示乌梅丸合痛泻药方治疗溃疡性结肠炎疗效优于补脾益肠丸。     

杨上善《太素》注通假字正误举隅

杨上善在《太素》注文中对通假字的处理 ,有着较为正确的认识。一方面能破借字以求本字 ,如亦、灸、靡、若等字 ;另一方面能依字而解 ,望文生训 ,如凶、佩、英、旬等字。     

真心痛化热现象临床观察与分析

目的：证实在“真心痛”的发病过程中有化热现象。方法：选择符合中、西医双重诊断标准的住院患43例进行系统观察。将舌质红、舌苔黄、发热、脉数作为观察指标,具备其中的三项即判定为具有热象。结果：在入选的病例中,有23例患有热象表现,见于各种梗塞部位的病例,约占53％。结论：在真心痛的发病过程中,化热现象是一种客观存在的病理特征,应作为辨证施治的重要依据。     

于年海教授运用通腹汤治疗炎性肠梗阻经验

介绍于年海教授对术后早期炎性肠梗阻病因病机的理论认识,及其运用中医中药治疗本病的临床经验总结。探讨通腹汤治疗炎性肠梗阻中医理论依据,以及中西医结合治疗本病的优势。     

血栓通联合依达拉奉对急性脑梗死患者神经功能、血液流变学及炎性反应的影响

目的:探讨血栓通联合依达拉奉治疗急性脑梗死临床疗效及对神经功能、血液流变学及炎性反应的影响。方法:100例急性脑梗死患者,分为观察组与对照组,50例/组。对照组使用依达拉奉治疗,观察组则在前者基础上加用血栓通注射液,两组均用药两周,比较两组患者症状积分、疗效以及治疗前后的神经功能、凝血功能及炎症反应指标的水平。结果:对照组总有效率为86%,观察组为94%,两组比较,P<0.05;治疗前对照组半身不遂、口眼歪斜、言语蹇涩与观察组比较无统计学意义,治疗后分别为(3.40±1.52)分、VS(2.00±1.98)分、(3.20±1.92)分VS(2.60±1.52)分、(3.70±1.70)分VS(2.70±1.64)分,两组比较,P<0.01;治疗后神经功能缺损评分比较,对照组积分为(15.83±4.58)分,观察组为8.82±3.73分,两组比较,P<0.01;治疗后APTT、TT、PT比较,观察组效果优于对照组,P<0.01;治疗后全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原、血小板聚集率比较,观察组效果优于对照组,P<0.05;IL-8、IL-6、TNF-α比较,观察组效果优于对对照组,P<0.05。结论:使用血栓通联合依达拉奉治疗急性脑梗死,不仅可以改善临床症状,还可以保护患者神经功能、调节血液流变学指标、抑制炎性反应、提高临床疗效。     

从“脑为元神之府”探讨中风急性期的辨治方略

文章主要阐述中风病的辨治方略,提出中风急性期作为急性脑梗死的一种,治疗当从脑论治,并从"脑为元神之府"学说来论证"通府以复元神"的理论依据,笔者认为补气活血法、化瘀通腑法、豁痰开窍法等皆属于"通法"的综合应用,是治疗中风病的最佳选择。从"脑为元神之府"的理论钩玄、中风病因病机及复元醒脑汤组方治疗三方面来阐述中风急性期的中医辨治方略,讨论中风病急性期的治疗,并论证了"通府以复元神"的理论依据,以期为中风病的临床治疗提供参考。     

络脉舒通对兔心肌梗死再灌流损伤保护作用的实验研究

目的探讨络脉舒通对兔急性心肌梗死（AMI）再灌流损伤心脏功能和氧自由基的影响。方法新西兰大白兔24只，随机分为络脉舒通组、对照组和假手术组，每组8只，制备AMI再灌流模型。观察各组血流动力学改变，检测丙二醛（MDA）、超氧化物岐化酶（SOD）和一氧化氮合酶（NOS）的变化，测量心肌梗死面积。结果（1）与对照组相比，络脉舒通组缺血-再灌流后2h左室收缩压（LVSP）和左心室内压最大收缩和舒张变化速率（±dp／dtmax）均显著升高（P〈0．05），LVEDP则显著下降（P〈0．05）。（2）对照组MDA含量比假手术组显著增高（P〈0．05），而SOD和NOS活性均显著降低（P〈0．05）；与对照组相比，络脉舒通组心肌梗死面积显著缩小（P〈0．05），心肌MDA含量显著降低（P〈0．05），心肌SOD和NOS活性均显著增高（P〈0．05）。结论络脉舒通具有清除氧自由基作用，可以减轻心肌再灌流损伤，改善心功能。     

Prenatal Bisphenol A exposure and early childhood neurodevelopment in Shandong,China

BackgroundSeveral epidemiological studies suggest that prenatal exposure to BPA may interfere with the neurodevelopment of pre-school and school-age children. However, a limited number of studies are available for effects during children at a younger age, especially in China.MethodsBased on Laizhou Wan Birth Cohort (LWBC), BPA concentrations were measured in urine among 506 pregnant women during their hospital admission for delivery and neurodevelopment of their children was assessed using the Gesell Development Schedules at 12 months (n = 368) and 24 months (n = 296). Linear regression and generalized linear models were used to analyze the association between prenatal BPA exposure and the children's developmental quotient scores (DQs).ResultsThe median of maternal BPA concentration was 0.48 μg/L or 1.05 μg/g creatinine. Maternal BPA concentrations were adversely associated with children DQs at 12 months of age, with a 10-fold increase in prenatal BPA concentrations correlated to 1.43-point decrease in DQs in the adaptive domain (β = ?1.43; 95% CI: ?2.30 to ?0.56, p = 0.001). When stratified by gender, prenatal BPA concentrations were adversely associated with the adaptive domain DQs among boys (p-trend = 0.012) and girls (p-trend = 0.028) and the social domain DQs (p-trend = 0.019) only among girls. At 24 months of age, the significant adverse association was only found in the language domain among girls (β = ?1.69; 95% CI: ?3.23 to ?0.15, p = 0.032).ConclusionBased on a Chinese population, we found potential impacts of prenatal BPA exposure on childhood neurodevelopment at 12 and 24 months of age, especially among girls.