全文获取类型
收费全文 | 15224篇 |
免费 | 1201篇 |
国内免费 | 433篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 247篇 |
妇产科学 | 73篇 |
基础医学 | 1200篇 |
口腔科学 | 224篇 |
临床医学 | 2013篇 |
内科学 | 2258篇 |
皮肤病学 | 45篇 |
神经病学 | 451篇 |
特种医学 | 684篇 |
外国民族医学 | 1篇 |
外科学 | 5120篇 |
综合类 | 2270篇 |
预防医学 | 393篇 |
眼科学 | 107篇 |
药学 | 949篇 |
10篇 | |
中国医学 | 271篇 |
肿瘤学 | 507篇 |
出版年
2024年 | 59篇 |
2023年 | 347篇 |
2022年 | 564篇 |
2021年 | 818篇 |
2020年 | 660篇 |
2019年 | 775篇 |
2018年 | 738篇 |
2017年 | 623篇 |
2016年 | 484篇 |
2015年 | 519篇 |
2014年 | 994篇 |
2013年 | 836篇 |
2012年 | 837篇 |
2011年 | 900篇 |
2010年 | 738篇 |
2009年 | 719篇 |
2008年 | 702篇 |
2007年 | 686篇 |
2006年 | 600篇 |
2005年 | 529篇 |
2004年 | 460篇 |
2003年 | 345篇 |
2002年 | 290篇 |
2001年 | 277篇 |
2000年 | 227篇 |
1999年 | 197篇 |
1998年 | 182篇 |
1997年 | 161篇 |
1996年 | 105篇 |
1995年 | 134篇 |
1994年 | 99篇 |
1993年 | 108篇 |
1992年 | 110篇 |
1991年 | 81篇 |
1990年 | 68篇 |
1989年 | 77篇 |
1988年 | 74篇 |
1987年 | 55篇 |
1986年 | 38篇 |
1985年 | 89篇 |
1984年 | 72篇 |
1983年 | 49篇 |
1982年 | 67篇 |
1981年 | 59篇 |
1980年 | 58篇 |
1979年 | 35篇 |
1978年 | 41篇 |
1977年 | 37篇 |
1976年 | 43篇 |
1975年 | 37篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
Scott A. Syverud MD J. Matthew Jenkins MD Robert A. Schwab MD Michael T. Lynch MD Kevin Knoop MD Alexander Trott MD 《Academic emergency medicine》1994,1(6):509-513
Objective: Mental nerve block is frequently used to aid repair of facial lacerations; both percutaneous and intraoral approaches to blocking this nerve are used, but have never been compared. The authors compared the two techniques for pain of administration and effectiveness of anesthesia. Methods: A prospective, randomized, single-blind, crossover study was conducted using ten healthy volunteers aged 22 to 33 years. Patients having prior experience with mental nerve blocks, lidocaine allergy, active oral/facial infection, or previous facial fractures were excluded. Bilateral mental nerve blocks were done using intraoral technique on one side and percutaneous technique on the other. Both techniques were used by the same investigator and were carried out with 27-gauge needles and 2.5 mL of 2% buffered lidocaine at room temperature injected over 20 seconds. The oral mucosa was topically anesthetized with viscous lidocaine for 1 minute prior to intraoral injection. The orders of the blocks and sides of the face anesthetized were randomized. Subjective and objective pain (visual-analog scale), efficacy (anesthesia of lower lip), time to onset, and duration of anesthesia were evaluated. Results: The intraoral technique was subjectively less painful than the percutaneous approach in nine of ten subjects (p = 0.02). Scores on the visual-analog pain scale were significantly lower for the intraoral technique (p = 0.03). Intraoral injection produced lower-lip anesthesia in 10/10 subjects versus 7/10 for percutaneous (p = 0.25). Times to onset (approximately 1–2 minutes) and durations of anesthesia (approximately one hour) were similar for the two techniques. Conclusion: The intraoral approach to the mental nerve block with adjunctive topical anesthesia was subjectively and objectively less painful than the percutaneous approach without adjunctive anesthesia. While the intraoral approach had a greater efficacy of lower-lip anesthesia and a longer duration of action, these differences were not statistically significant. 相似文献
72.
Preoperative metoprolol improves cardiovascular stability and reduces oxygen consumption after thoracotomy 总被引:1,自引:0,他引:1
C.–J. JAKOBSEN S. BILLE P. AHLBURG L. RYBRO K. D. PEDERSEN B. RASMUSSEN 《Acta anaesthesiologica Scandinavica》1997,41(10):1324-1330
Background : Increased sympathetic activity perioperatively and associated cardiovascular effects play a central role in cardiovascular complications. High thoracic epidural blockade attenuates the sympathetic response, but even with complete pain relief, haemodynamic and endocrine responses are still present. Beta–adrenoceptor blockade is effective in situations with increased sympathetic activity. This study was designed to evaluate the perioperative haemodynamic effect of preoperative βblockade and its influence on the haemodynamic aspects of the surgical stress response.
Methods : Thirty–six otherwise healthy patients undergoing elective thoracotomy for lung resection were randomised doubleblinded to receive either 100 mg metoprolol or placebo preoperatively. Anaesthesia was combined high thoracic epidural block and general anaesthesia. The epidural analgesia was continued during recovery. Patients were monitored with ECG, pulse oximetry, invasive haemodynamic monitoring, arterial blood gases and electrolytes.
Results : After induction of anaesthesia the mean arterial pressure (MAP) decreased in both groups, and decreased further in the placebo group after initiation of the epidural block. The heart rate (HR) was slightly less throughout the observation period after metoprolol. Peroperatively, the only difference in measured haemodynamics was a marginally higher MAP after metoprolol. Postoperative cardiac index (CI) was lower with a lower variability and cardiac filling pressures were slightly higher in the metoprolol group. The oxygen consumption index was higher after placebo throughout the observation period, with no difference in the oxygen delivery.
Conclusion. We found that preoperative β–blockade during combined general anaesthesia and high thoracic epidural blockade stabilised perioperative HR and CI and decreased total oxygen consumption. 相似文献
Methods : Thirty–six otherwise healthy patients undergoing elective thoracotomy for lung resection were randomised doubleblinded to receive either 100 mg metoprolol or placebo preoperatively. Anaesthesia was combined high thoracic epidural block and general anaesthesia. The epidural analgesia was continued during recovery. Patients were monitored with ECG, pulse oximetry, invasive haemodynamic monitoring, arterial blood gases and electrolytes.
Results : After induction of anaesthesia the mean arterial pressure (MAP) decreased in both groups, and decreased further in the placebo group after initiation of the epidural block. The heart rate (HR) was slightly less throughout the observation period after metoprolol. Peroperatively, the only difference in measured haemodynamics was a marginally higher MAP after metoprolol. Postoperative cardiac index (CI) was lower with a lower variability and cardiac filling pressures were slightly higher in the metoprolol group. The oxygen consumption index was higher after placebo throughout the observation period, with no difference in the oxygen delivery.
Conclusion. We found that preoperative β–blockade during combined general anaesthesia and high thoracic epidural blockade stabilised perioperative HR and CI and decreased total oxygen consumption. 相似文献
73.
对AF系统整复压缩爆裂骨折椎体高度及椎管横截面的观测 总被引:4,自引:3,他引:1
目的 :量化评价AF系统恢复胸腰段压缩爆裂椎体高度椎管截面积的效果。方法 :测量AF系统治疗的 72例胸腰段压缩爆裂骨折术前后影像。统计椎体前后缘高度、Cobb角、椎管截面积资料。结果 :术后伤椎前缘高度恢复至 ( 96.5± 2 .3 ) %后缘高度恢复至 ( 98.2± 0 .9) % ,Cobb角恢复至 ( 5 .4± 1.5 )° ,椎管截面积恢复至 ( 97.2± 2 .1% ) ,各项指标与术前比较有非常显著性差异 (P <0 .0 0 1)。术后随访 0 .5~ 3 .5年 ,神经功能按Frankel评定 :60例提高 1~ 3级。结论 :AF系统能恢复或基本恢复胸腰段压缩爆裂骨折椎体的前后缘高度、Cobb角、椎管容积 ,为脊髓神经功能的恢复提供一个良好的环境。是治疗脊柱胸腰段压缩爆裂骨折较好的内固定器。 相似文献
74.
Complications associated with maxillary nerve block anaesthesia via the greater palatine canal 总被引:2,自引:0,他引:2
Anthony M. Sved John D. Wong Head Peter Donkor James Horan Leesa Rix Justin Curtin and Russell Vickers 《Australian dental journal》1992,37(5):340-345
This paper documents the type, frequency and duration of complications associated with regional anaesthesia of the maxillary nerve via the greater palatine canal in a series of 101 patients treated in the Oral Surgery Department, United Dental Hospital of Sydney. 相似文献
75.
P. M. Parizel G. Rodesch D. Balériaux D. Zegers de Beyl J. D'Haens J. Noterman C. Segebarth 《Neuroradiology》1989,31(1):75-79
Summary The Gd-DTPA-enhanced magnetic resonance findings in two patients with herniated thoracic intervertebral discs are reported. The first patient was a 56-year-old woman with a small subligamentous T6-7 disc herniation, slightly lateralized to the right. The second patient was a 51-year-old man with a central and right posterolateral disc herniation, including a large calcified fragment, at the T8-9 level. The nonenhanced MR examination revealed the presence of an extradural mass lesion in both patients, impinging upon the dural sac and compressing and displacing the spinal cord posteriorly. The lesion was slightly hypointense on both T1- and T2-weighted spin echo sequences. Following intravenous injection of Gd-DTPA in a dosage of 0.1 mmol/kg body weight, enhancement of the posterior longitudinal ligament was noted and triangular areas of contrast uptake were seen to occur in the epidural space above and below the herniated disc. At surgery, they were found to correspond to dilated and congested epidural veins. 相似文献
76.
目的:比较未经正规治疗的高血压患者中位和低位硬膜外阻滞时对血压的影响。方法:有明确的高血压病史的急诊中上腹部手术麻醉病例42例(Ⅰ组)和下腹部手术麻醉病例47例(Ⅱ组),采用硬膜外阻滞后,比较手术时间、局麻药总量、麻醉后动脉血压下降的幅度和时相。结果:(Ⅰ组)手术历时62.3±17.8min,局麻药总量为利多卡因387.0±31.2mg,(Ⅱ组)手术历时56.8±14.9min,利多卡因总量366.7±30.1mg,均无显著差异。Ⅰ组硬膜外麻醉前平均动脉压为123.6±13.2mmHg,麻醉后最低的平均动脉压为69.5±10.0mmHg,出现最低平均动脉压的中位时间为26.3min,Ⅱ组麻醉前的平均动脉压为117.3±15.7mmHg,麻醉后最低平均动脉压为71.0±7.4mmHg,出现最低平均动脉压的中位时间为21.3min。两组在硬膜外阻滞后平均动脉压下降幅度及下降时间方面无显著差异。结论:未经很好控制的高血压患者硬膜外阻滞后均可引起血压急骤下降,低位硬膜外阻滞与中高位阻滞引起的血压下降幅度和时相相似。 相似文献
77.
A low concentration of transition metal ions Co2+ and Ni2+ increases the inward current density in neurons from the land snail Helix aspersa. The currents were measured using a single electrode voltage-clamp/internal perfusion method under conditions in which the external Na+ was replaced by Tris+, the predominant external current carrying cation was Ca2+, and the internal perfusate contained 120 mM Cs+/0 K+; 30 mM tetraethylammonium (TEA) was added externally to block K+ current. In the presence of Co2+ (3 mM) or Ni2+ (0.5 mM) inward Ca2+ currents were stimulated normally by voltage-dependent activation of Ca2+ channels. There was a 5-10% decrease in the rate of rise of the inward current. The principal effect of Co2+ and Ni2+ in increasing the current density seems to be a decrease in the rate at which the inward currents decline during a depolarizing voltage pulse. The results may be due to a decrease in a voltage-dependent or Ca(2+)-dependent outward current and/or an inhibition of Ca2+ channel inactivation. Outward current under these conditions (zero internal K+) was significant and most likely due to Cs+ efflux through the voltage-activated or Ca(2+)-activated nonspecific cation channels. Co2+ is an extremely effective blocker of this outward current. These results are not an artifact of internal perfusion or the special ionic conditions. Intracellular recording of unperfused neurons in normal Helix Ringer's solution showed that the Ca(2+)-dependent action potential duration was increased significantly by low concentrations of Co2+. This result is consistant with the Co(2+)-dependent increase in inward (depolarizing) current seen in voltage-clamp experiments. 相似文献
78.
Bilateral continuous paravertebral block used for postoperative analgesia in an infant having bilateral thoracotomy 总被引:3,自引:0,他引:3
We describe the successful postoperative pain management in an 11-month-old infant who underwent bilateral thoracotomy, using continuous infusions of bupivacaine into two directly placed paravertebral catheters. Haemodynamic parameters and pain scores were measured 1–2 h for 60 h while the infusions were continued and, intermittently, blood samples were taken for subsequent measurement of serum bupivacaine concentrations. The technique provided effective pain relief and the infant required no other analgesia postoperatively. There were no adverse haemodynamic consequences or complications relating to either catheter placement or drug infusions. Serum concentrations of bupivacaine remained below toxic levels throughout the study period, though accumulation did occur. 相似文献
79.
80.
S. COHEN D. AMAR E. J. PANTUCK N. SINGER M. DIVON 《Acta anaesthesiologica Scandinavica》1994,38(7):716-718
To examine the effects of prolonged (> 24 h) intrathecal catheterization with the use of postoperative analgesia on the incidence of post–dural puncture headache (PDPH), charts of 45 obstetric patients who had accidental dural puncture following attempts at epidural block were reviewed retrospectively. Three groups were identified: Group I (n = 15) patients had a dural puncture on the first attempt at epidural block, but successful epidural block on a repeated attempt; Group II (n=17) patients had a dural puncture with immediate conversion to continuous spinal anaesthesia with catheterization lasting only for the duration of caesarean delivery; Group III (n= 13) patients had an immediate conversion to spinal anaesthesia and received post–caesarean section continuous intrathecal patient–controlled analgesia consisting of fentanyl 5 (ig'ml-1 with bupivacaine 0.25 mg·ml-1 and epinephrine 2 μg·ml-1 with catheterization lasting >24 h. No parturient in group III developed a PDPH. This was substantially lower ( P < 0.009) than the 33% incidence for group I and the 47% incidence for group II. The incidence of a PDPH did not differ between group I and II. Similarly, there was no difference between group I and II with regard to requests for a blood patch. Patients receiving continuous intrathecal analgesia had excellent pain relief, could easily ambulate and none complained of pruritus, nausea, vomiting, sensory loss or weakness. In conclusion, indwelling spinal catheterization > 24 h with continuous intrathecal analgesia following accidental dural puncture in parturients may for some patients be a suitable method for providing PDPH prophylaxis and postoperative analgesia. 相似文献