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31.
激光热疗中生物组织的光热特性响应以及动态热损伤研究 总被引:6,自引:0,他引:6
考虑到生物组织的光学、热学特性参数以及血液灌注率与组织温度和组织热损伤的依赖关系 ,模拟了激光热疗中激光在生物组织中的传输、生物组织的动态热响应和热损伤 ,以及血液灌注率的变化。通过分析激光功率和激光头尺寸对热疗效应的影响 ,得出了一些有益于肿瘤热疗临床的结论。 相似文献
32.
随着癌症治疗水平的不断提升,脊柱转移瘤患者的生存期得到显著延长。当前脊柱转移瘤的治疗呈现多模式趋势,临床采用的手术方式包括椎体肿瘤切除椎管减压重建内固定术、分离手术、微创手术和经皮消融技术等,放疗技术包括传统外照射治疗、立体定向放疗和近距离放疗等。椎体肿瘤切除椎管减压重建内固定术的手术风险较大,术中和术后并发症的发生率较高,术后恢复期的延长可能造成后续放疗和其他内科治疗的延误,对患者的生存期和治疗信心都造成严重影响。而传统外照射治疗的精准度不高,脊髓耐受性的限制使得放疗剂量常难以达到控制放疗不敏感肿瘤的目的。随着放疗和手术技术的发展,精准性更高的立体定向放疗和手术创伤更小的分离手术脱颖而出,成为目前临床医生关注的焦点。本文就分离手术联合立体定向放疗的Hybrid治疗的研究进展作一综述。 相似文献
33.
目的观察热化联合对肺癌患者A549细胞生长的影响及机制探讨。方法对A549细胞分别进行单独热疗、单独化疗,热化联合干预及热化联合并SP600125干预,同时选取未做任何处理的A549细胞作为对照组。观察各组细胞增殖率、细胞侵袭力的变化。同时采用蛋白免疫印记法(Western Bolt)检测JNK磷酸化以及热休克蛋白70(HSP70)的表达。结果热化联合组的A549细胞增值率明显低于单独热疗、单独化疗和热化联合并SP600125组(P<0.05)。热化联合组JNK磷酸化表达明显高于对照组及单独化疗组(P<0.05),热化联合组HSP70表达明显低于单独热疗组(P<0.05)。热化联合干预下,p-JNK表达水平出现上升,与对照组、单独热疗组和单独化疗组相比,差异均具有统计学意义(P<0.05);热化联合并SP600125组的p-JNK的表达水平较热化联合组显著下降(P<0.05)。结论热化联合抑制A549细胞增殖的效果优于单独热疗或单独化疗,作用机制可能与激活JNK信号通路或抑制HSP70表达有关。 相似文献
34.
目的 探讨围热疗期护理对肿瘤患者接受热疗时可耐受的最高体温的影响.方法 按随机数字表法将86例肿瘤患者分为为2组:围热疗期护理组(43例)、未给予围热疗期护理组(43例),比较2组患者在接受热疗时可耐受的最高体温.结果 接受围热疗期护理组的患者可耐受体温要高于未接受围热疗期护理组[ (39.74±0.77)℃比(39.09±0.98)℃],差异有统计学意义(t=3.692,P=0.002).结论 护士针对欲接受热疗肿瘤患者给予必要的围热疗期护理,可提高患者在热疗时可耐受的体温,从而达到更好的热疗疗效. 相似文献
35.
目的 :回顾分析经动脉超选择热栓塞化疗治疗肝癌后碘油沉积和疗效的关系。方法 :随机将 6 9例肝癌患者分为两组 ,实验组灌注热碘油栓塞剂 (5 5℃~ 6 5℃ )和化疗药与生理盐水混合剂 ,经微导管注入肝癌滋养动脉。对照组热碘油栓塞剂和化疗药与生理盐水温度控制在 2 0℃。术后复查甲胎蛋白 (AFP)及 CT,独立盲法评价碘油沉积情况及肿瘤大小变化 ,对比两组肝癌患者生存率。结果 :实验组碘油沉积 :良好 36例、不良 3例 ,与对照组对比有极显著差异 (P<0 .0 0 1)。实验组生存率 :6个月、12个月、18个月、2 4个月、36个月、4 8个月分别为 :10 0 %、97%、90 %、79%、6 2 %、38% ,与对照组对比有显著差异 (P<0 .0 5 )。结论 :热化疗栓塞治疗肝癌 ,其操作简单 ,碘油沉积良好 ,能显著提高疗效 ,延长患者生存期 相似文献
36.
目的探讨直肠癌手术前热疗配合同期放化疗的临床疗效及术后病理改变的特点。方法对76例局部进展期直肠癌患者进行了手术前热疗加同期放化疔。局部热疗采用和佳HG-2000高频热疗机,放疗前1小时内完成,每周2次,放疗方式为盆腔前后对穿照射,每天2Gy,每周5次连续放疗,总剂量46Gy。在放疗开始后的第1周和第5周,同期予以四氢叶酸+5-Fu全身化疗2周期。术前辅助治疗完成后4—6周实施手术。结果T复查肿瘤的直径平均缩小36%,其中8例(11%)术后达到病理完全缓解,另外54例(71%)达到PR,癌细胞坏死率≥50%,总有效率达82%。术前综合治疗后淋巴结阳性率南68%降至45%。术后病理检查所有肿瘤组织,均见不同程度的癌细胞变性、细胞结构破坏、肿瘤血管破坏、出血及大片凝同性坏死。瘢痕区域可见灶性钙化、再生上皮。结论前热疗配合同期放化疗可以使直肠肿瘤缩小、减少局部淋巴结转移率,部分病例可以获得病理完全缓解。 相似文献
37.
Wei Shen Tan Anesh Panchal Laura Buckley Adam J. Devall Laurence S. Loubière Ann M. Pope Mark R. Feneley Jo Cresswell Rami Issa Hugh Mostafid Sanjeev Madaan Rupesh Bhatt John McGrath Vijay Sangar T.R. Leyshon Griffiths Toby Page Dominic Hodgson Shibendra N. Datta John D. Kelly 《European urology》2019,75(1):63-71
Background
There is no effective intravesical second-line therapy for non–muscle-invasive bladder cancer (NMIBC) when bacillus Calmette-Guérin (BCG) fails.Objective
To compare disease-free survival time (DFS) between radiofrequency-induced thermo-chemotherapy effect (RITE) and institutional standard second-line therapy (control) in NMIBC patients with recurrence following induction/maintenance BCG.Design, settings, and participants
Open-label, phase III randomised controlled trial accrued across 14 centres between May 2010 and July 2013 (HYMN [ClinicalTrials.gov: NCT01094964]).Intervention
Patients were randomly assigned (1:1) to RITE (60 min, 40 mg mitomycin-C, 42 ± 2 °C) or control following stratification for carcinoma in situ (CIS) status (present/absent), therapy history (failure of previous induction/maintenance BCG), and treatment centre.Outcome measurements and statistical analysis
Primary outcome measures were DFS and complete response (CR) at 3 mo for the CIS at randomisation subgroup. Analysis was based on intention-to-treat.Results and limitations
A total of 104 patients were randomised (48 RITE: 56 control). Median follow-up for the 31 patients without a DFS event was 36 mo. There was no significant difference in DFS between treatment arms (hazard ratio [HR] 1.33, 95% confidence interval [CI] 0.84–2.10, p = 0.23) or in 3-mo CR rate in CIS patients (n = 71; RITE: 30% vs control: 47%, p = 0.15). There was no significant difference in DFS between treatment arms in non-CIS patients (n = 33; RITE: 53% vs control: 24% at 24 mo, HR 0.50, 95% CI 0.22–1.17, p = 0.11). DFS was significantly lower in RITE than in control in CIS with/without papillary patients (n = 71; HR 2.06, 95% CI 1.17–3.62, p = 0.01; treatment-subgroup interaction p = 0.007). Disease progression was observed in four patients in each treatment arm. Adverse events and health-related quality of life between treatment arms were comparable.Conclusions
DFS was similar between RITE and control. RITE may be a second-line therapy for non-CIS recurrence following BCG failure; however, confirmatory trials are needed. RITE patients with CIS with/without papillary had lower DFS than control. HYMN highlights the importance of the control arm when evaluating novel therapies.Patient summary
This study did not show a difference in bladder cancer outcomes between microwave-heated chemotherapy and standard of care treatment. Papillary bladder lesions may benefit from microwave-heated chemotherapy treatment; however, more research is needed. Both treatments are similarly well tolerated. 相似文献38.
Cindy den Herder Dennis Kox Harm van Tinteren Nico de Vries 《European archives of oto-rhino-laryngology》2006,263(11):1031-1040
We assessed adverse events and complications of bipolar radiofrequency induced thermotherapy of the tongue base (RFTB) in patients with socially unacceptable snoring (SUS) or obstructive sleep apnea syndrome (OSAS) and determine its acceptance and effectiveness when conducted under local anesthesia. This investigation consisted of (1) a prospective, open-enrolment study of 24 consecutive patients with snoring and OSAS at the tongue base level only (Fujita III), assessed by sleep endoscopy. Polysomnography, questionnaires, and visual analog scales (VAS) were used to assess outcome. (2) In addition, a retrospective review of 83 patients, who underwent RFTB (in 59 cases as part of a multilevel treatment), was performed to evaluate adverse events and complications. Twenty-two of the 24 patients completed postoperative questionnaires and VAS, and ten patients had postoperative polysomnography. Reduction in snoring (P = 0.0003), hypersomnolence (P = 0.002), and globus (P = 0.031) was significant. A positive trend in AHI (P = 0.001, n = 3) is shown in patients with moderate to severe OSAS. Concerning postoperative adverse events and complications, only two patients had a mild and transient tongue deviation directly after the procedure, which resolved within an hour postoperatively (adverse event rate 1.8%). No postoperative complications such as infections, abscesses, hematomas, or ulcerations of the tongue base occurred. This study demonstrates that bipolar RFTB in patients with obstruction at the tongue base only (Fujita type III) as visualized by sleep endoscopy is a safe and simple procedure under local anesthesia and can be effective in patients with SUS. No complications during this study were observed. Its effect on OSAS has been shown by other authors, although long-term effects are not stable. The RFTB can be considered as first choice treatment in case of snoring and mild OSAS in Fujita type III obstruction. In the case of moderate to severe sleep apnea, RFTB can be considered as an additional treatment. 相似文献
39.
奥沙利铂联合热疗对血管生成的抑制作用 总被引:3,自引:1,他引:2
目的探讨奥沙利铂(L-OHP)联合热疗在体内外对血管生成的抑制作用。方法采用四甲基偶氮唑盐(MTY)法观察L-OHP联合热疗对人脐静脉内皮细胞(HUVEC)和人结肠癌LOVO细胞增殖的影响;采用transwell实验观察L-OHP联合热疗对HUVEC迁移的影响;采用鸡胚绒毛尿囊膜(CAM)模型观察L-OHP对CAM新生血管的抑制作用。结果0.5~16μs/ml L-OHP均具有抑制HUVEC增殖的作用,细胞存活率为80.1%~42.5%,其增殖速度与L-OHP浓度呈负相关(r=-0.943, P=0.005);在此浓度范围内,L-OHP对LOVO细胞增殖的抑制明显低于对HUVEC的抑制。0.5、1和16μg/ml L-OHP与热疗对HUVEC增殖的抑制具有协同作用,2、4和8μg/ml L-OHP与热疗具有相加作用。0.25~2μg/ml L-OHP具有抑制HUVEC迁移的作用,细胞迁移抑制率为18.7%~53.0%。1、4μg/ml L-OHP对CAM新生血管具有明显的抑制作用,抑制率分别为70.0%和100.0%。结论小剂量L-OHP在体内外具有抑制血管生成的作用,联合热疗对抑制HUVEC增殖具有协同或相加效应。 相似文献
40.
目的 研究和观察局部加温疗法联合外用药物治疗面部寻常型痤疮的临床疗效与安全性.方法 40例中度寻常痤疮的患者随机分为两组,试验组采用局部皮损处加温疗法联合外用药物治疗,每一皮损每次治疗3min,每日治疗3次,每次治疗完毕后同时外用克林霉素甲硝唑擦剂;对照组外用克林霉素甲硝唑擦剂,每日3次.两组治疗后每周进行1次疗效评定,总疗程为2周.结果 试验组与对照组治疗1周的总有效率分别为86.79%、66.67%,治疗两周的总有效率分别上升为94.34%、81.25%,两组均相差显著(P>0.05).结论 应用局部加温疗法联合外用药物治疗面部寻常性痤疮的具有临床疗效高与安全性好的优势,值得临床上应用和推广. 相似文献